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DocTalk with Dr. Adam Nally

DocTalk with Dr. Adam Nally

By Adam S Nally DO

Dr. Nally sharing insights with his community about health, wellness, nutrition and medicine . . . essentially all things that make living life in this crazy world better.
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Will Keto Increase My Risk for Heart Attack or Heart Disease?

DocTalk with Dr. Adam NallyMar 08, 2023

00:00
12:55
Will Keto Increase My Risk for Heart Attack or Heart Disease?

Will Keto Increase My Risk for Heart Attack or Heart Disease?

Listen as Dr. Nally debunks the recent American College of Cardiology findings regarding use of a ketogenic diet and increased heart disease risk.  Why is this the worst medical article Dr. Nally has ever read?  Listen and find out.  We also talk about the labs you should be watching and closely following while in a ketogenic or carnivorous lifestyle.  

Check out Dr. Nally's Cholesterol Mini-Course at https://www.docmuscles.com/cholesterol/

#Cholesterol #STATIN #LDL #Creatine #Diet #Food #FoodIsMedicine #LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife #PlantBasedDietsSuck #Muscles #NoBSsm #Exercise

References:

  1. ACC Annual Scientific Session News Article - https://www.acc.org/latest-in-cardiology/articles/2023/03/01/22/45/sun-1215pm-kctogenic-acc-2023


Mar 08, 202312:55
Erythritol, is it going to give me a heart attack or stroke?

Erythritol, is it going to give me a heart attack or stroke?

Don't miss this podcast as Dr. Nally discusses the sugar alcohol, erythritol, and what the Cleveland Clinic's study really means to those following a Ketogenic Lifestyle.  Is there another reason behind attacking erythritol?  After hearing this podcast, you decide.

#Erythritol #Polyols #HeartDisease #Stroke #Diet #Food #FoodIsMedicine #LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife #PlantBasedDietsSuck

#Gorgeous #Muscles

Show notes:

  1. Witkowski, M., Nemet, I., Alamri, H. et al. The artificial sweetener erythritol and cardiovascular event risk. Nat Med (2023). https://doi.org/10.1038/s41591-023-02223-9
  2. Bornet FRJ, Blayo A, Dauchy F, Slama G. Plasma and Urine kinetics of Erythritol after Oral Ingestion in Health Humans. Reg Toxicol Pharm. 0ct 1996. 24(2):S280-S285.  https://doi.org/10.1006/rtph.1996.0109
  3. Proctor and Gamble partners with Clevland Clinic and their heart lab to develop a heart disease biomaker in Nov 2022. https://www.marketscreener.com/quote/stock/PROCTER-GAMBLE-COMPANY-4838/news/Procter-Gamble-Partners-with-Cleveland-Clinic-Cleveland-HeartLab-to-Develop-Heart-Disease-Biomar-38269523/
  4. Molino G, Avagnina P, Cavanna A, Ballarè M, Torchio M, Bona B, Belforte G. Sorbitol clearance: a parameter reflecting liver plasma flow in the rat. Res Commun Chem Pathol Pharmacol. 1986 Apr;52(1):119-32. PMID: 3715193.
  5. Polyol Diagram - https://www.researchgate.net/figure/Fig-2-Schematic-of-the-Polyol-Pathway-blue-shaded-area-and-its-links-to-the_fig2_5630519
Mar 02, 202323:17
GLP-1 Use & Muscle Loss

GLP-1 Use & Muscle Loss

With the recent explosion in popularity of the GLP-1 agonist medications for obesity, Dr. Nally discusses a little known problem (muscle loss) becoming more significant with these drugs popularity. 

If you've ever considered using any of these medications in this class, you'll want to tune in to this podcast. 

#GLP1 #semaglutide #dulalutide #tirzepatide #liraglutide #exanatide #sarcopenia #Diet #Food #FoodIsMedicine #LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife #PlantBasedDietsSuck #Muscles #Cytokines #incretin #NoBSsm #Exercise

References:

  1. Wilding JPH, et al. STEP 1 Study Group of the Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med 2021; 384:989-1002.  DOI: 10.1056/NEJMoa2032183.
  2. McCrimmon, R.J., Catarig, AM., Frias, J.P. et al. Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial. Diabetologia 63, 473–485 (2020). https://doi.org/10.1007/s00125-019-05065-8
Feb 21, 202311:17
Creatine and the Broken Heart

Creatine and the Broken Heart

Dr. Nally talks about creatine and all of its benefits.  Since it's Valentines, he discusses how ketosis and creatinine can fix a broken heart.  You don't want to miss this one.

#Creatine #Diet #Food #FoodIsMedicine #LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife #PlantBasedDietsSuck #Skin #Skincare #BeautifulSkin #SkinCarePrimer #Face #Gorgeous #Muscles #Cytokine

References:

  1. Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Exp Gerontol. 2018 Jul 15;108:166-173. doi: 10.1016/j.exger.2018.04.013. Epub 2018 Apr 25. PMID: 29704637; PMCID: PMC6093191.
  2. Kreider RB. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 2003 Feb;244(1-2):89-94. PMID: 12701815.
  3. Kreider RB, Stout JR. Creatine in Health and Disease. Nutrients. 2021 Jan 29;13(2):447. doi: 10.3390/nu13020447. PMID: 33572884; PMCID: PMC7910963.
Feb 15, 202311:25
Why Is My Glucose Still High?

Why Is My Glucose Still High?

Dr Nally gives the answers to the Egg IQ quiz and answers questions about the causes of persistent elevated blood sugars while following a ketogenic or carnivorous lifestyle.

Body Weight Exercise Program: https://q0y908pr.pages.infusionsoft.net

Weight Management & Concierge Medicine: https://www.DocMuscles.com/membership/

#Glucose #Cytokines #BloodSugar #LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife #PlantBasedDietsSuck #PicoSure #Icon #SculpSure #TempSure #EMScuptNeo #EMSella #EMFace  #Skin #Skincare #BeautifulSkin #SkinCarePrimer #Face #Gorgeous

#NoBSsm #Muscles #Myokines #Exercise

References:

  1. Li Y et al., J Diabetes Res. May 2013. Online. ID 170532, p1-8
  2. Sonksen P, Sonksen J. Brit J. Anaesth. July 2000. 85(1): 69-79
  3. Nieto-Vazquez, I et al., Archieves of Physiol Biochem. 2008. 114(3): 183-194
  4. Cook CJ, Phys Behav, Sep 2004, 82:4; 751-762
  5. Herman, J P et al. Braz Jour Med Biol Res, Mar 2012, 45:4; 292-8
  6. McEwen, B., Neuropsychopharmacol, 2000 22:108–124.
  7. Khan S, Shafiei MS, Longoria C, Schoggins J, Savani RC, Zaki H. SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway. bioRxiv [Preprint]. 2021 Mar 17. Update in: Elife. 2021 Dec 06:10.
Feb 13, 202317:50
The Pen, The Notepad & Your Memory

The Pen, The Notepad & Your Memory

Dr. Nally's checks your Egg IQ asking you five questions about eggs.   Send your answers and your T-shirt size to questions@docmuscles.com. The first person to correctly answer will win a free DocMuscles.com T-Shirt.  

Dr. Nally talks about how a pen and notepad can change your memory in just 66 days.  You're not going to want to miss this one.  

Dr. Nally's Favorite Leather Notebook Cover: https://amzn.to/3JQyX7Z

Dr. Nally's Favorite Moleskin Journal: https://amzn.to/3YxKf5H

Show Note References:

  1. Umejima K, Ibaraki T, Yamazaki T, Sakai K. Paper notebooks vs mobile devices: Brain activation differences during memory retrieval.  Front. Behav. Neurosci., 19 March 2021(15). https://doi.org/10.3389/fnbeh.2021.634158
  2. Vanderbilt University, Treadway M, Zald D. Dopamine impacts your willingness to work.  Journal of Neuroscience 2 May 2012.
Feb 10, 202313:42
Myokines and Weight Loss

Myokines and Weight Loss

Listen as Dr. Nally discusses the hormonal effects on weight loss caused by exercise.  He explains why resistance type exercise or HIIT exercise is so very important in a weight loss program.  

You can download a copy of his body weight exercise program for free at https://www.docmuscles.com/exercise

Myokines and Weight loss blog post: https://www.docmuscles.com/myokines-and-weight-loss/

Show Note References:

  1. Pedersen BK. Muscles and their myokines. J Exper Biol. 2011. 214:337-346.  doi:10.1242/jeb.048074.
  2. Furuichi Y, Manabe Y, Takagi M, Aoki M, Fujii NL (2018) Evidence for acute contraction induced myokine secretion by C2C12 myotubes. PLoS ONE 13(10): e0206146. https://doi.org/ 10.1371/journal.pone.0206146.
  3. Han LJ & Hee-Sook J. Role of Myokines in Regulating Skeletal Muscle Mass and Function. Frontiers in Physiology. Jan 2019. Vol 10:1-9. doi: 10.3389/fphys.2019.00042

    #LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife #PlantBasedDietsSuck
    Dr Nallys Lasers: #PicoSure #Icon #SculpSure #TempSure #EMScuptNeo #EMSella #EMFace  
    #NoBSsm #Muscles #Myokines #Cytokines #BDNF #Exercise
Feb 07, 202310:42
Protein & Weight Loss

Protein & Weight Loss

Dr Nally reviews the recent thyroid medication recall and discusses how protein and muscle maintenance plays a key role in weight loss.  

https://www.docmuscles.com/dietpage/

#LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife #PlantBasedDietsSuck #NoBSsm

Show References:

  1. https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/ibsa-pharma-inc-issues-voluntary-nationwide-recall-select-lots-tirosintr-sol-levothyroxine-sodium
  2. Kiddy DS, Hamilton-Fairley D, Seppala M, Koistinen R, James VHT, Reed MJ, Franks S. DIET-INDUCED CHANGES IN SEX HORMONE BINDING GLOBULIN AND FREE TESTOSTERONE IN WOMEN WITH NORMAL OR POLYCYSTIC OVARIES: CORRELATION WITH SERUM INSULIN AND INSULIN-LIKE GROWTH FACTOR-I. Clin Endocrin. Dec 1989 https://doi.org/10.1111/j.1365-2265.1989.tb01297.x
  3. James N. Roemmich and Wayne E. Sinning. Weight loss and wrestling training: effects on growth-related hormones. Journal of Applied Physiology 1997 82:6, 1760-1764.
  4. Adeva-Andany MM, Funcasta-Calderón R, Fernández-Fernández C, Castro-Quintela E, Carneiro-Freire N. Metabolic effects of glucagon in humans. Journal of Clinical & Translational Endocrinology. 2019 Mar;15:45-53. DOI: 10.1016/j.jcte.2018.12.005. PMID: 30619718; PMCID: PMC6312800.
  5. Ho KY, Veldhuis JD, Johnson ML, Furlanetto R, Evans WS, Alberti KG, Thorner MO. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest. 1988 Apr;81(4):968-75. doi: 10.1172/JCI113450. PMID: 3127426; PMCID: PMC329619.
  6. Møller N, Jørgensen JO, Abildgård N, Orskov L, Schmitz O, Christiansen JS. Effects of growth hormone on glucose metabolism. Horm Res. 1991;36 Suppl 1:32-5. PMID: 1806481.
  7. Antonio, J., Peacock, C.A., Ellerbroek, A. et al. The effects of consuming a high protein diet (4.4 g/kg/d) on body composition in resistance-trained individuals. J Int Soc Sports Nutr 11, 19 (2014). https://doi.org/10.1186/1550-2783-11-19
  8. Longland TM, Oikawa SY, Mitchell CJ, Devries MC, Phillips SM. Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial. Am J Clin Nutr. 2016 Mar;103(3):738-46. doi: 10.3945/ajcn.115.119339. Epub 2016 Jan 27. PMID: 26817506.
  9. Jay R. Hoffman, Michael J. Falvo. (2004) Protein - Which is Best?. Journal of Sports Science and Medicine (03), 118 - 130.
  10. Fenzl M et al., Release of ANP and Fat Oxidation in Overweight Persons during Aerobic Exercise in Water. Int J Sports Med. Feb 2013. Vol 34. doi: 10.1055/s-0033-1333696
Feb 05, 202314:23
Five Steps to Unlock Your Amygdala and Reach Your Potential: Hope, The Limbic System, & Cravings

Five Steps to Unlock Your Amygdala and Reach Your Potential: Hope, The Limbic System, & Cravings

In Episode 6, Dr. Nally dives into willpower, hope and how this relates to motivation.  He talks about the amygdala and it's effect on cravings, addiction and the autonomic nervous system.   Listen in as he gives 5 steps to controlling anxiety, panic & cravings.  How can a ketogenic lifestyle help irritable bowel?  Find out on today's podcast. 

References:

1. Berenz EC, Vujanovic AA, Coffey SF, Zvolensky MJ. Anxiety sensitivity and breath-holding duration in relation to PTSD symptom severity among trauma exposed adults. J Anxiety Disord. 2012 Jan;26(1):134-9. doi: 10.1016/j.janxdis.2011.10.004. Epub 2011 Oct 17. PMID: 22047652; PMCID: PMC3254809.

2. McKay, M., Wood, J.C. and Brantley, J. (2007) The Dialectical Behavior Therapy Skills Workbook. New Harbinger, Oakland.

3. Van Dijk, T. A. (2013). The field of Epistemic Discourse Analysis. Discourse Studies, 15(5), 497–499. https://doi.org/10.1177/1461445613501448

4. The Human Amygdala, by Paul J. Whalen & Elizabeth A. Phelps (2009)

5. Molecules of Emotion The Science Behind Mind-Body Medicine, by Candace B. Pert (1997)

6.Wibowo, E., Wong, S.T.S., Wassersug, R.J. et al. Sexual Function After Voluntary Castration. Arch Sex Behav 50, 3889–3899 (2021). https://doi.org/10.1007/s10508-021-02094-6

7. Britta K. Hölzel, James Carmody, Karleyton C. Evans, Elizabeth A. Hoge, Jeffery A. Dusek, Lucas Morgan, Roger K. Pitman, Sara W. Lazar, Stress reduction correlates with structural changes in the amygdala, Social Cognitive and Affective Neuroscience, Volume 5, Issue 1, March 2010, Pages 11–17, https://doi.org/10.1093/scan/nsp034

8 . Lowen MBO, et al. Effect of hypnotherapy and educational intervention on brain response to viscerla stimulation in the irritable bowel syndrome.  Aliment Pharmacol Ther. 2013 June ; 37(12): 1184–1197. doi:10.1111/apt.12319.

9. Sumithran P., Prendergast L. A., Delbridge E., Purcell K., Shulkes A., Kriketos A., et al. . (2011). Long-term persistence of hormonal adaptations to weight loss. N. Engl. J. Med. 365, 1597–1604. 10.1056/NEJMoa1105816

10. Transforming Therapy by Gil Boyne  (1989).


#DocTalk  #LimbicSystem #amygdala #Cravings # Anxiety #PanicAttacks #IBS #PrinciplesOfLife #DeepThoughts #ChangeYourThoughtsChangeYourLife #ChronicIllness #ChronicDisease #ObesityMedicineSpecialist #HormoneSpecialist #ClinicalHypnotherapist #JustKeepEsterifying #WhoIsListeningAnyway #DocMuscles #DocMusclesLife #LeadFollowOrGetOutOfMyWay #DocTalk #LiftRunShootKetoForLife #KeepHammering #ImNotDeadYet #Keto #Carnivore #Ketogenic  #BaconMakesYourPantsFallOff

Dec 05, 202234:35
The Polyol Pathway & Diabetic Disease Progression

The Polyol Pathway & Diabetic Disease Progression

Listen in as Dr. Nally answers listener's questions and discusses the Polyol Pathway relating to diabetic disease progression, important information about sweeteners, and why people seem to improve their health on a plant based diet.  Your not going to want to miss this one.

References:

1. Molino G, Avagnina P, Cavanna A, Ballarè M, Torchio M, Bona B, Belforte G. Sorbitol clearance: a parameter reflecting liver plasma flow in the rat. Res Commun Chem Pathol Pharmacol. 1986 Apr;52(1):119-32. PMID: 3715193.

2. Polyol Diagram - https://www.researchgate.net/figure/Fig-2-Schematic-of-the-Polyol-Pathway-blue-shaded-area-and-its-links-to-the_fig2_5630519

3. Zhou Y, et al., “Insulin secretion stimulating effect of Mogroside V and fruit extract of luo han kuo (Siraitia Grosvenori Swingle) fruit extract.” Yao Xue Xue Bao 44, no. 11 (2009): 1252-1257. www.ncbi.nlm.nih.gov/pubmed/21351724.

4. Horm Metab Res. 1987 Jun; 19(6):233-8.

5. Horm Metab Res. 1987 Jul; 19(7):285-9

6. Franchi F, Yaranov DM, Rollini F, Rivas A, Rivas Rios J, Been L, Tani Y, Tokuda M, Iida T, Hayashi N, Angiolillo DJ, Mooradian AD. Effects of D-allulose on glucose tolerance and insulin response to a standard oral sucrose load: results of a prospective, randomized, crossover study. BMJ Open Diabetes Res Care. 2021 Feb;9(1):e001939.

Dec 01, 202218:24
Nose Bleeds & Tampons

Nose Bleeds & Tampons

Listen as Dr. Nally talks about epistaxis (nose bleeds), how that relates to this season and the history of tampons.  You don't want to miss this episode. 

References:

  1. Habiger Petra, "Menstration, Menstral Hygen and Women's Health in Ancient Egypt." 199.  http://www.mum.org/germnt5.htm
  2. Bakry, S., Merhi, Z.O., Scalise, T.J. et al. Depot-medroxyprogesterone acetate: an update. Arch Gynecol Obstet 278, 1–12 (2008). https://doi.org/10.1007/s00404-007-0497-z
  3. https://www.wondersandmarvels.com/2014/11/the-history-of-tampons-in-ancient-greece.html - Hippocrates use of tampons
  4. Harris K & Caskey-Sigety L. The Medieval Vagina - https://onthetudortrail.com/Blog/2015/02/10/the-lady-in-red-medieval-menstruation/
  5. Medei VC.  A History of Endocrinology.  1982. https://link.springer.com/book/10.1007/978-94-009-7304-6?utm_medium=referral&utm_source=google_books&utm_campaign=3_pier05_buy_print&utm_content=en_08082017
Nov 30, 202215:25
Gout: The King's Disease

Gout: The King's Disease

Listen in as Dr. Nally discussed the history of gout, why Hippocrates only thought it happened to royalty and how you can treat and prevent it with a ketogenic or carnivorous lifestyle. 

Show Note Sources: 

Kanbara A., Seyama I. Effect of urine pH on uric acid excretion by manipulating food materials. Nucleosides, Nucleotides Nucleic Acids. 2011;30(12):1066–1071. Towiwat P., Li Z.G. The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout. Int J Rheum Dis. 2015;18(5):495–501. Bedir A., Topbas M., Tanyeri F., Alvur M., Arik N. Leptin might be a regulator of serum uric acid concentrations in humans. Jpn Heart J. 2003;44(4):527–536. Garrod AB. The Nature and Treatment of Gout and Rheumatic Gout, 2nd ed, Walton and Maberly, London 1863. Dalbeth N, Phipps-Green A, Frampton C, et al. Relationship between serum urate concentration and clinically evident incident gout: an individual participant data analysis. Ann Rheum Dis 2018; 77:1048. Hall AP, Barry PE, Dawber TR, McNamara PM. Epidemiology of gout and hyperuricemia. A long-term population study. Am J Med 1967; 42:27. Campion EW, Glynn RJ, DeLabry LO. Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am J Med 1987; 82:421. Zalokar J, Lellouch J, Claude JR, Kuntz D. Epidemiology of serum uric acid and gout in Frenchmen. J Chronic Dis 1974; 27:59. BRILL JM, MCCARTY DJ. "STUDIES ON THE NATURE OF GOUTY TOPHI" BY MAX FREUDWEILER, 1899. (AN INFLAMMATORY RESPONSE TO INJECTED SODIUM URATE, 1899). AN ABRIDGED TRANSLATION, WITH COMMENTS. Ann Intern Med 1964; 60:486. McCarty DJ, Hollander JL. Identification of urate crystals in gouty synovial fluid. Ann Intern Med 1961; 54:452. Seegmiller JE, Howell RR, Malawista SE. The inflammatory reaction to sodium urate: its possible relationship to the genesis of acute gouty arthritis. JAMA 1962; 180:469. Hutton J, Fatima T, Major TJ, et al. Mediation analysis to understand genetic relationships between habitual coffee intake and gout. Arthritis Res Ther 2018; 20:135. Fanning N, Merriman TR, Dalbeth N, Stamp LK. An association of smoking with serum urate and gout: A health paradox. Semin Arthritis Rheum 2018; 47:825. Lin KC, Lin HY, Chou P. Community based epidemiological study on hyperuricemia and gout in Kin-Hu, Kinmen. J Rheumatol 2000; 27:1045. Zhang Y, Woods R, Chaisson CE, et al. Alcohol consumption as a trigger of recurrent gout attacks. Am J Med 2006; 119:800.e13. Hunter DJ, York M, Chaisson CE, et al. Recent diuretic use and the risk of recurrent gout attacks: the online case-crossover gout study. J Rheumatol 2006; 33:1341. Chhana A, Lee G, Dalbeth N. Factors influencing the crystallization of monosodium urate: a systematic literature review. BMC Musculoskelet Disord 2015; 16:296. Loeb JN. The influence of temperature on the solubility of monosodium urate. Arthritis Rheum 1972; 15:189. Horvath SM, Hollander JL. INTRA-ARTICULAR TEMPERATURE AS A MEASURE OF JOINT REACTION. J Clin Invest 1949; 28:469. Martinon F, Pétrilli V, Mayor A, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440:237. Guerne PA, Terkeltaub R, Zuraw B, Lotz M. Inflammatory microcrystals stimulate interleukin-6 production and secretion by human monocytes and synoviocytes. Arthritis Rheum 1989; 32:1443. Terkeltaub R, Zachariae C, Santoro D, et al. Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation. Arthritis Rheum 1991; 34:894. di Giovine FS, Malawista SE, Thornton E, Duff GW. Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution. J Clin Invest 1991; 87:1375. Guerne PA, Terkeltaub R, Zuraw B, Lotz M. Inflammatory microcrystals stimulate interleukin-6 production and secretion by human monocytes and synoviocytes. Arthritis Rheum 1989; 32:1443.

Nov 22, 202218:21
Cowboys and Lectins

Cowboys and Lectins

In Episode 2, Dr. Nally addresses the cowboys perception of vegetarians and vegans, presents a little cowboy poetry (you don't want to miss this) and discusses lectins. 

Cowboy Poetry by Baxter Black, "Vegetarians Nightmare" 

Show Notes:

  1. https://www.researchgate.net/publication/343273411_Do_Plants_Feel_Pain?
  2. https://ndpr.nd.edu/reviews/plant-minds-a-philosophical-defense/
  3. https://www.um.es/web/minimal-intelligence-lab/
  4. Wang Q, et al. Identification of intact peanut lectin in peripheral venous blood. Lancet. Dec 5 1998. Vol 352;1943. p1831-1832.  DOI:https://doi.org/10.1016/S0140-6736(05)79894-9.
  5. Shechter Y. Bound lectins that mimic insulin produce persistent insulin-like activities. Endocrinology. 1983 Dec;113(6):1921-6. doi: 10.1210/endo-113-6-1921. PMID: 6357762.
  6. Zheng J, Wang M, Wei W, Keller JN, Adhikari B, King JF, King ML, Peng N, Laine RA. Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease. Front Nutr. 2016 Mar 7;3:7. doi: 10.3389/fnut.2016.00007. PMID: 27014695; PMCID: PMC4780318.
Nov 20, 202216:05
Why Did I Regain Weight While Following a Ketogenic or Carnivorous Diet?

Why Did I Regain Weight While Following a Ketogenic or Carnivorous Diet?

Dr. Nally's discusses the reasons and science behind why people regain weight following a low carb lifestyle and how to fix it.   And, a bit of Thanksgiving history . . . You won't want to miss this epsiode.

Show notes:

  1. Seimon RV, Roekenes JA, Zibellini J, Zhu B, Gibson AA, Hills AP, Wood RE, King NA, Byrne NM, Sainsbury A. “Do intermittent diets provide physiological beneftis over continuous diets for weight loss? A systematic review of clinical trials.” Mol Cell Endo. 15 Dec 2015. 418(2): 153-172.
  2. Byrne NM, Sainsbury A, King NA, Hills AP, Wood RE. “Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study.” Int J Obes. 2018. 42:129-138.  https://www.nature.com/articles/ijo2017206
  3. Trepanowski JF, Kroeger CM, Barnosky A. “Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults.” JAMA Intern Med. Jul 2017. 177(7): 930-938. https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2623528?redirect=true
  4. Delezie J & Handschin C. Endocrine Crosstalk Between Skeletal Muscle and the Brain. Frontiers in Neurology. VOL 9(2018). https://www.frontiersin.org/articles/10.3389/fneur.2018.00698.  DOI=10.3389/fneur.2018.00698
  5. Antonio J, Peacock CA, Ellergroek A, Fromhoff B & Silver T (2014) The effects of consuming a high protein diet (4.4g/kg/d) on body composition in resistance-trained individuals. Journal of the International Society of Sports Nutrition. 11(1), 19.
  6. Figueiredo VC. (2019) Revisiting the roles of protein synthesis during skeletal muscle hypertrophy induced exercise. Am J Physiol Regul Integr Comp Physiol, 317:R709-R718.
  7. Longland TM, Oikawa SY, Mitchell CJ, Devries MC, Phillips SM (2016) Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial. The American Journal of Clinical Nutrition. 103(3), 738-746.
  8. Luca-Moretti, M (1998) A comparative, double-blind, triple crossover net nitrogen utilization study confirms discovery of the master amino acid pattern. Age (years). 152(176), 41-45.
  9. Hoffman JR & Falvo MJ (2004). Protein-which is best?  Journal of Sports Science and Medicine. 3(3). 118.
Nov 20, 202231:24
Chronic Kidney Disease - Prequel Episode

Chronic Kidney Disease - Prequel Episode

Reversing chronic kidney disease (CKD) with a ketogenic lifestyle.   

Dr. Nally's Ketogenic Dietary Information: https://www.docmuscles.com/dietpage/  

Show References: 

1. Siperstein MS, Unger RH, Madison LL. “Further Electron Microscopic Studies of Diabetic Microagniopathy.” Early Diabetes: Advances in Metabolic Disorders, sup 1. New York: Academic Press, 1972, p261-271. 

2. Nasr SH, D’Agati VD.  “Nodular glomerulosclerosis in the nondiabetic smoker.”  J Am Soc Nephrol. 2007;18(7):2032. 

3. Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV (2011) Reversal of Diabetic Nephropathy by a Ketogenic Diet. PLoS ONE 6(4): e18604. doi:10.1371/journal.pone.0018604 

4. Kundu S, Hossain KS, Moni A, Zahan MS, Rahman MM, Uddin MJ. Potentials of ketogenic diet against chronic kidney diseases: pharmacological insights and therapeutic prospects. Mol Biol Rep. 2022 Oct;49(10):9749-9758. doi: 10.1007/s11033-022-07460-8. Epub 2022 Apr 20. PMID: 35441940. 

5. Rojas-Morales P, León-Contreras JC, Sánchez-Tapia M, Silva-Palacios A, Cano-Martínez A, González-Reyes S, Jiménez-Osorio AS, Hernández-Pando R, Osorio-Alonso H, Sánchez-Lozada LG, Tovar AR, Pedraza-Chaverri J, Tapia E. A ketogenic diet attenuates acute and chronic ischemic kidney injury and reduces markers of oxidative stress and inflammation. Life Sci. 2022 Jan 15;289:120227. doi: 10.1016/j.lfs.2021.120227. Epub 2021 Dec 16. PMID: 34921866. 

6. Jolliffe N, Smith HW. The excretion of urine in the dog. I. The urea and creatinine clearances on a mixed diet. Am J Physiol 98: 572–577, 1931. 

7. Parving HH, Noer J, Kehlet H, Mogensen CE, Svendsen PA, Heding L. The effect of short-term glucagon infusion on kidney function in normal man. Diabetologia 13: 323–325, 1977pmid:334617. 

8. Fioretto P, Trevisan R, Velussi M, Cernigoi A, De Riva C, Bressan M, Doria A, Pauletto N, Angeli P, De Donà C, et al. Glomerular filtration rate is increased in man by the infusion of both D,L-3-hydroxybutyric acid and sodium D,L-3-hydroxybutyrate. J Clin Endocrinol Metab. 1987 Aug;65(2):331-8. doi: 10.1210/jcem-65-2-331. PMID: 3298305.  

#CKD #ChronicKidneyDisease #Kidney #diabeticNephropathy #Diabetes #LeadFolloworGetOutOrMyWay #JustKeepEsterifying #Ketogenic #Keto #KetogenicLifestyle #Carnivore #DrAdamNally #DocMuscles #DocMusclesLive #DocTalk #DocsWhoLift #LiftRunShoot #DocMusclesLife YouTube.com/drnally/.

Nov 13, 202208:40