Computationally Yours

After more than 1 year of working remotely for computational professionals, hosts Arshi Arora and Dr. Sabah Kadri do a deep dive into what we have learned, how remote work has evolved, fun activities to stay active and the future of remote work in the industry. An easy-to-listen and fun episode!

Follow Sabah's YouTube channel for fun Dance workouts (Yes, you read that right. Listen to the episode to learn more): 

Episode 4 dives into Statistics with guest, Dr. Jaya Satagopan. Hosts Dr. Sabah Kadri and Arshi Arora asked FIVE burning questions in statistics involving degrees of freedom, intercepts, hypothesis testing and more. Listen to Dr. Satagopan explain complex concepts using simple examples. 

Let us know what is your favorite statistical summary metric too. Our email is computationallyyours@gmail.com. 

After a hiatus of 2 months, we are back with a new schedule of an episode every 2 weeks.

In this episode, hosts Dr. Sabah Kadri and Arshi Arora discuss the genetics of our cute furry friends, the effects of domestication on natural selection and how years of in-breeding have led to the study of clear mappings between dog traits and gene variants. Our hosts gave each other a task to come up with some interesting traits and their genetic markers. A must listen.

Ostrander, E. A., & Wayne, R. K. The canine genome. Genome Research 15, 1706–1716 (2005) doi:10.1101/gr.3736605 

Parker, H. G., et al. Genetic structure of the purebred domestic dog. Science 304, 1160–1164 (2004) doi:10.1126/science.1097406

Björnerfeldt, S., et al. Relaxation of selective constraint on dog mitochondrial DNA following domestication. Genome Research 16, 990–994 (2006) doi:10.1101/gr.5117706

In this episode, our special guest, Dr. Debjani Sihi from Emory University talks to hosts Dr. Sabah Kadri and Arshi Arora, about the nuts and bolts of climate science. We dive in the real questions of climate change in accessible language. Curious about Green House gasses (GHG) or whether taking flights contribute global warming? What is the difference between weather and climate? What are the largest misconceptions surrounding climate science? Tune in to find out much more!

Welcome to the second season of Computationally Yours! In this very first episode of 2021, your hosts Dr. Sabah Kadri and Arshi Arora kick-off with the latest updates in the COVID-19 pandemic, the vaccines. We talk about different types of vaccines, the science behind them, and the amount of misinformation surrounding these immunizations. Tune into this brand new episode as Sabah talks about her own experience of getting vaccinated!

In this season finale episode, we discuss recent scientific news covering COVID vaccines and vaccine related jargon, results from a simulation study related to climate change and the nature communication paper describing influence of gender on mentor ship. See you soon in 2021!

Email us at: computationallyyours@gmail.com

In light of the monumental weekend in the United States, we got thinking about women who changed Science forever, and the first name that comes up is Marie Curie. This episode highlights her fascinating story. 

Email us at: computationallyyours@gmail.com

In this episode, Arshi Arora takes you over a brief journey of data science and statistics in the field of Genomics. What are the steps of a typical data analysis pipeline, and some fun analogies to understand basic to complicated statistical concepts.

We would love to hear from you if you think we missed something or you would like us to cover something more.

Email us at: computationallyyours@gmail.com

Starting this month, we will be highlighting the main news in science for the month. This month, we highlighted three main stories:

1. Nobel Prize in Chemistry for CRISPR

2. Editorial in New England Journal of medicine “Dying in a Leadership Vacuum”

3. What's new in Remdesivir news? Contradicting evidence publications and FDA approval.

In this episode of Computationally Yours, host Dr. Sabah Kadri discusses a topic she has been mulling over converting into an episode for a long time - the nuts and bolts of Bioinformatics. She introduces the field, discusses its fuzzy history and then shares nuggets of wisdom for both new and aspiring Bioinformaticians talking about things she wishes she knew when she was starting out.

We would love to hear from you if you think we missed something or you would like us to cover something more.

Email us at: computationallyyours@gmail.com

In this new episode, hosts Arshi Arora and Dr. Sabah Kadri discuss their professional stories in Computational Biology of more than a decade. They discuss their career paths, starting from what it takes to decide that one follows a doctorate degree to doing two Masters degrees. We hope students in the field, especially women in science enjoy hearing about our stories. To cap this engaging story exchange, we end the episode with our most embarrassing professional stories. 

Write to us and let us know your story. 

Email us at: computationallyyours@gmail.com

In this first of its kind episode in the field, host Dr. Sabah Kadri assembled a panel of distinguished Clinical Bioinformatics Directors for this very special episode. Dr. Eric Klee (Mayo Clinic), Dr. Ahmet Zehir (Memorial Sloan Kettering) and Dr. Matthew Hestand (Cincinnati Children's) talk about being leaders in the field, the challenges of hiring clinical bioinformaticians and some good training practices. You will get to know these scientists up close and personal with some fun daredevil questions posed by our host and walk away with many lessons. This is one fun ride!

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

In this episode, your hosts, Dr. Sabah Kadri and Arshi Arora bring to you united yet diverse sub fields of Computational Biology in the voice of four different scientists, spanning areas of Structural Biology, Systems Biology, Chemistry, Proteomics and Genomics. They cover their background, speciality and what drew them to Computational ability in the first place.

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

In this episode, Dr. Sabah Kadri and Arshi Arora discuss the viewpoints of 6 esteemed scientists from the latest Nature review Genetics paper celebrating 20 years. From population genetics to non-coding genome, from equity to diversity and more, this is a must listen.

Paper discussed: https://pubmed.ncbi.nlm.nih.gov/32839576/

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

In our next “Profiles of Scientific Genius” series, we bring to you the life story of the Father of Modern Genetics, Gregor Johann Mendel (1822-1884). Dr. Sabah Kadri and Arshi Arora talk about his journey from a monk to a scientist, his iconic work on pea plants, Mendel's Laws of inheritance, and lastly a brief note about the  Mendel-Fisher controversy.

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

In this episode, we sat down with hosts of 5 other podcasts on pathology and science: Deeper Levels, People of Pathology, PathPod, ScopeMD, and Dead Men Do Tell Tales for a Mega crossover episode.  We talk about podcasting, what got us started on this journey, what we have learned, and even share a joke. It was fun to share and learn from our fellow podcasters.

Other podcasts featured in this episode:

In today’s episode, we reached out to four diagnostic experts across the United States to share their experiences in bringing on SARS-CoV-2 testing in their laboratories. We asked them to share the biggest challenge they faced and also share one thing with the listeners of Computationally Yours that isn’t common knowledge about this testing. Dr. Sabah Kadri takes our listeners through some basics of SARS-CoV-2 (COVID-19) testing and lays out these unique challenges from our guests. Thank you to our guests: Dr. Karen Kaul (Chair of Pathology and Lab Medicine Northshore Univ Health System), Dr. Eric Konnick (Assistant Professor, Associate Director - Genetics and Solid Tumor Laboratory, Director - Genetics Pre-analytical Services at the Department of Laboratory Medicine and Pathology University of Washington), Dr. Julie Woolworth Hirschhorn (Assistant Professor, Associate Director Molecular Pathology at Medical University of South Carolina) and an unnamed molecular pathologist at a large hospital in Texas.

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

In this episode, hosts, Dr. Sabah Kadri and Arshi Arora dive deep into the launch of a genetic test - what does it mean? What are the types of genetic testing? What goes into designing a genetic test? What is involved in validating this test clinically? What are the accuracy metrics? An easy listen covering a very complex topic.

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

In this episode, hosts, Dr. Sabah Kadri and Arshi Arora ask leading experts in Molecular Pathology across clinical laboratories across the United States, their personal experience with Precision Medicine, its effect on their clinical practice as well as their views of the future of personalized medicine. Ours guests for this episode are:
Dr. Rashmi Kanagal-Shamanna, Hematopathologist, Molecular Genetic Pathologist, Associate Professor at MD Anderson Cancer Center
Dr. Mark Ewalt, Hematopathologist at Memorial Sloan Kettering
Dr. Alanna Church, Associate Director, LaMPP at Boston Children's Hospital Assistant Professor of Pathology, Harvard Medical School
Dr. Joshua Coleman , Assistant Professor of Pathology at the University of Utah and Medical Director at ARUP Laboratories
Dr. Kailee Yap, Director of Molecular Diagnostics, Assistant Professor of Pathology from Lurie Children’s hospital
Dr. Somak Roy, Assistant Professor and Molecular Pathologist, The University of Pittsburgh Medical Center

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com

Did you know there was a time when no one knew about blood groups so no one knew to check the blood group of a donor before transfusion? There was also a time when a patient's treatment could not be tailored to their DNA changes. But none of that happens today. Do you know why? And do you know how? Listen to Dr. Sabah Kadri break down precision medicine and its revolutionary effects on patient care in this extremely engaging episode. We take an anecdote-filled roller coaster from the 1800s to 2020. Enjoy the ride!

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

Our hosts, Dr. Sabah Kadri and Arshi Arora are women in science celebrating a friendship that spans over a decade. In this episode, we get up-close and personal to get to know our hosts, their journeys in science and the hardships along the way. They discuss what excites them about science (Spoiler alert: it's everything), an embarrassing revelation and advice for young scientists starting out in the field. Join us in getting to know the people who bring you Computationally Yours.

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

Our DNA makes us unique. It also makes us similar to each other - sometimes more and sometimes less. How? Dr. Sabah Kadri and Arshi Arora explore similarities and differences in our DNA. And in the process, they discuss milestone genomics projects in human beings such as dbSNP, the HapMap project and Genome Wide Association Studies. They look at studies all the way from one that looks at genetic factors involved in Covid-19 to one that investigates the genetics of curly hair. This one is a fun ride.

Ever wonder what it is like to study the genomics of microbes likes bacteria and viruses? Dr. Sabah Kadri talks with Dr. Egon Ozer about the field of microbial genomics, the relatively fast evolution of microbes and the study from Dr. Ozer's group studying the genomic sequences of SARS-CoV-2, the virus in the COVID-19 pandemic. Tune in as we learn about this field, its challenges and methodologies.

Link to paper discussed: https://www.medrxiv.org/content/10.1101/2020.05.19.20107144v1

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

Dr. Sabah Kadri and Arshi Arora discuss the landmark project that changed genomics and bioinformatics forever: The Human Genome project. They discuss the what, why and how as well as the interesting stories that mark the journey of the human genome.

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

Infectious disease expert, Dr. Andrew Trotter discusses clinical trials in infectious diseases with Dr. Sabah Kadri and Arshi Arora in this episode of Computationally Yours. This is Part 2 in a 2-part series on clinical trials. We dive into what makes clinical trials in infectious diseases or conducting trials for vaccines different, and the importance of participation of patients in these trials. This episode makes complex concepts simple and approachable #accesibleScience

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

Dr. Sabah Kadri and Arshi Arora discuss the basics of clinical trials and give the listeners a fun 101 course on how trials are designed and some fundamental concepts of the process. You do not need to be an expert in Science to learn about Clinical Trials with us #accessibleScience

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com.

In our second episode, Dr. Nicholas Soulakis breaks down Contact Tracing for our listeners and discusses the role of data and computational modeling in the contact tracing program. Dr. Soulakis is a career epidemiologist currently supporting the contact tracing program for the Illinois Department of Public Health. #accessibleScience #contactTracing

Contact us with questions, feedback and requests to collaborate on future episodes at computationallyyours@gmail.com

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