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By Deep Tech Show

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Advancing precision synthetic biology to meet humankind’s greatest challenges + Jacob Vogan

Deep Tech ShowFeb 17, 2023

00:00
31:33
Advancing precision synthetic biology to meet humankind’s greatest challenges + Jacob Vogan

Advancing precision synthetic biology to meet humankind’s greatest challenges + Jacob Vogan

Edmar Ferreira talks with Jacob Vogan, co-founder and Chief Scientific Officer of CB Therapeutics, where he designs and leads large projects to engineer microorganisms to produce high-value molecules, both natural and new-to-nature, for use in therapeutics, nutraceuticals, animal-free food, and more. Jacob and Sher started CB Therapeutics in their garage, and after several lab expansions and going through Y Combinator, the start-up is now housed in a 16,000 sq. ft state-of-the-art facility with a growing and experienced team outside San Diego, California.

In today’s episode, Jacob shared how the future looks like when CB Therapeutics is successful, the therapeutics that they developed, including the process that they have gone through upon producing their technology. Jacob shared about synthetic biology, their supply chain and compound, about the process of supplements. Jacob also shared his background, and how they started CB Therapeutics, Jacob also shared the lessons he learned from the markets. They also talked about mentors from their mental health technology, and how CB Therapeutics shows their progress with their investors. Find out Jacob’s message for everyone, and much more!

Feb 17, 202331:33
Regenerative Liver Technologies + Dr.Eric Schuur

Regenerative Liver Technologies + Dr.Eric Schuur

Edmar Ferreira talks with Dr.Eric Schuur, CEO and co-founder of HepaTx. He is a tenacious, creative innovator whose chief joy is bringing new ideas to life for patients suffering from difficult-to-treat diseases. Dr. Schuur has been innovating in the life science industry for 25 years and he has abundant start-up and emerging company experience with many early-stage companies, including Calydon, Inc. and Asthmatx, Inc.

Dr.Schuur shared how the future looks like when HepaTx is successful, how they started HepaTx, the idea behind creating HepaTx, and the technology that they are using to fix liver diseases including the transplant, he also shared the clinical trials that they made and about their first product in the upcoming year. Dr. Schuur also shared how their procedures work with HepaTx, the process, and the program that they go through with their technology. They also talked about the best advise from Dr.Schuur for any startup company, and much more!

Feb 14, 202323:49
Creating next generation smart cell therapies + Scott Boyken

Creating next generation smart cell therapies + Scott Boyken

Edmar Ferreira talks with Scott Boyken, co-founder and CSO of Outpace Bio, which uses protein design to create mechanism-driven solutions that dramatically improve the efficacy and safety of cell and gene therapies. Scott created protein switches and logic gates capable of modularly controlling biological function in cells and precisely targeting immunotherapies, resulting in over 20 publications and the Burroughs Wellcome Fund Career Award at the Scientific Interface.

Scott shared how the future looks like when Outpace Bio is successful, he also shared the incredible interface of proteins and the designs that tailored cell therapy solutions through protein designs and custom programming, like cell therapies, especially for the anti-cancer and life cancer cells like leukemia. They also talked about the reason behind Outpace Bio uses the idea of functional protein designs and structures, nanotechnology, the methods of Outpace Bio in order to solve the problems, the biggest problem in microbiology, reversing the sequence of the protein designs, the methods they have in Outpace Bio, the enzymes designs that they have, and their amazing programs. Scott also tells us his life story of why he ended up working with protein designs and the new biology and much more!

Feb 10, 202340:02
Remove CO2 and Put Oil Back Underground + Peter Reinhardt

Remove CO2 and Put Oil Back Underground + Peter Reinhardt

Edmar Ferreira talks with Peter Reinhardt CEO and co-founder at Charm Industrial, where they are developing novel carbon removal & renewable industrial syngas technology. Prior to Charm Industrial, Peter was CEO and co-founder at Segment, a SaaS customer data platform that grew to 600 people before it was acquired by Twilio in 2020 for $3.2B.

Peter shared the story behind Charm Industrial, how it started, his background in organizing the Charm Industrial, and how they come up with the idea of Charm Industrial. He also shared the technology and the products that they built with Charm. They also talked about the other areas that have a significant impact on industries nowadays and other economic transformations in starting a company and other world trends that have an impact nowadays. Peter also shared some misconceptions about their technology and their successful process with Charm Industrial, and Peter also shared how their injections work and the step-by-step process with their technology, and much more!

Feb 07, 202342:40
Fastest AI Accelerator + Andrew Feldman

Fastest AI Accelerator + Andrew Feldman

Edmar Ferreira talks with Andrew Feldman, co-founder and CEO of Cerebras Systems. He is an entrepreneur dedicated to pushing boundaries in the compute space. Prior to Cerebras, he co-founded and was CEO of SeaMicro, a pioneer of energy-efficient, high-bandwidth microservers.

In today’s episode, they talk about what the future looks like when Cerebras Sytems is amazingly successful, Andrew shared how they started Cerebras Systems, the story behind the invention of their technology, they also talked about the technology and experiments of Cerebras, and the compute performance of many tens to hundreds of graphics processing units, their massive gains in space and power efficiency for AI. Edmar also shared that money can’t buy any expertise. Andrew also shared the data processing they discovered when they started, the movement of information, the difficult part of calculations, and the best advice from Andrew when it comes to AI and bioengineering, and much more! 

Feb 03, 202342:42
Mobile platform for chronic pain and anxiety + Julien Soros

Mobile platform for chronic pain and anxiety + Julien Soros

Edmar Ferreira talks with Julien Soros, co-founder, and CTO at Flowly. He has a background in Electrical Engineering from Yale University where he focused on Systems and Controls as well as Digital Signal Processing. Previously, Julien worked at Hyperloop One on their Transponics team doing control algorithm design and monte carlo system stability analysis.

In today’s episode, they talk about what the future looks like when Flowly is amazingly successful, and the technology that they developed with Flowly, like the mobile app that they developed with Flowly and what it can do for people, how it reduces chronic pain and the anxiety management for a hundred millions of people. Julien also shared how they started and the history behind the development of Flowly, and how did they process their first patient after they developed their prototype. Julien also walk us through how to use the mobile app when subscribed to Flowly, he also described what you will experience with the mobile app of Flowly and how it works. And they also talked about the challenges that they are facing with Flowly, in terms of virtual reality and how people focus on biofeedback, and much more!

Jan 27, 202331:50
Helping patients across the globe who suffer from pain and chronic conditions + Dan Goldberger

Helping patients across the globe who suffer from pain and chronic conditions + Dan Goldberger

Edmar Ferreira talks with Dan Goldberger, CEO, and Director of electroCore, with the mission of helping patients across the globe who suffer from pain and chronic conditions. And Dan has over 35 years of leadership and medical device experience. 


In today’s episode, they talk about the mission of electroCore, the variety of treatments that they are treating using their technology, and the non-invasive therapy including all of their surgical inventions. Dan also shared how they started electroCore, how they were able to get FDA approvals, and the power of non-invasive ways, their innovation, and their technology to develop a safe and clinically backed treatment. They also talked about how did electroCore covered insurance, some recommendations from Dan about biotechnology, including the three stages to show progress and how they do consumer awareness of electroCore, and how their device works and including if how did they develop it. Discover more about Dan Goldberger and his best advice for start-up companies, and much more!


Jan 20, 202337:12
Drone as a First Responder technology giving first responders a live overhead view + Divy Shrivastava

Drone as a First Responder technology giving first responders a live overhead view + Divy Shrivastava

Edmar Ferreira talks with Divy Shrivastava, CEO and founder of Paladin Drones. Paladin Drones is a startup, building a custom drone hardware and software solution for cities to be able to respond to emergencies faster and with better data. And their mission is to deploy autonomous drones to 911 calls.

In today’s episode, they talk about what the future looks like with Paladine Drones, and the technologies that they are using in Paladine Drones. Divy shared some stories of successes and responding to calls for help. Divy also shared his life story and the story behind Paladin Drones and how they started. They also talked about how the software and the LTE work with the drones that they were using and respond to 911 calls. Divy also shared his great experience and learnings when he started Paladine Drones. And discover the best advise from Divy for those start-up companies and much more!

Jan 13, 202341:44
Live biological neurons with silicon to create a new hybrid-biological computer chip + Hon Weng Chong

Live biological neurons with silicon to create a new hybrid-biological computer chip + Hon Weng Chong

Edmar Ferreira talks with Hon Weng Chong, CEO, and founder of Cortical Labs. Hon helped set the vision and build teams to deliver the world's first bio-hybrid computing platform that leverages the developments in Synthetic Biology and Artificial Intelligence.

In today’s episode, they talk about what the future looks like with Cortical Labs, the technologies that they are developing and using in Cortical Labs, including the neurons that they are building, how they get the neurons, and the process they go through with their technology in Cortical Labs. Hon also shared how they are connecting the neurons with the computers, how they encode and decode the data with the neurons, and how they encode a lost function, as well as the assumptions with the neurons. Discover the best advise from Hon Weng Chong for those start-up companies and many more interesting things to discover with Cortical Labs!

Jan 07, 202301:08:31
Helps children with disabilities walk + Manmeet Maggu

Helps children with disabilities walk + Manmeet Maggu

Edmar Ferreira talks with Manmeet Maggu, co-founder and CEO of Trexo Robotics. His commitment to helping children with cerebral palsy walk drove the vision for Trexo Robotics and continues to guide his leadership style within the company.

In today’s episode, they talk about what the future looks like with Trexo Robotics, the 2020 problem and technological solutions for those people who need care, and they also talked about the current technology with Trexo Robotics and all the disabilities that Trexo Robotics supports. Manmeet also shared the reason why they created Trexo Robotics and how they started, he also shared his story of why he chose robotics engineering. He also describes how a kid controls the device of Trexo Robotics. Discover the best advise from Manmeet Maggu for those start-up companies and much more!

Dec 28, 202230:15
Affordable connectivity everywhere on Earth + Ryan McLinko

Affordable connectivity everywhere on Earth + Ryan McLinko

Edmar Ferreira talks with Ryan McLinko,  chief technology officer and co-founder of Astranis Space Technologies, which designs, builds, and operates smaller, lower-cost, geostationary communications satellites to connect unconnected people anywhere in the world.

In today’s episode, they talked about what the future looks like with Astranis, the technology that they have in Astranis, the connectivity that they created with their technology, and they also talked about why Ryan chose to study and work in space, and Ryan also shared that biotechnology is also the field that he is also interested. They also talked about the history of Astranis, how it started way back in 2015 and how the funding dynamic process when they started, and the type of areas on earth that are now connected, especially in the field of internet connectivity, and the small comms satellite for geostationary orbit. And Ryan also describes the difference between Astranis from other deep tech companies. Discover the best advise from Ryan McLinko for those start-up companies and much more!

Dec 16, 202240:04
Extending the healthspan and lifespan of dogs + Celine Halioua

Extending the healthspan and lifespan of dogs + Celine Halioua

Edmar Ferreira talks with Celine Halioua, CEO and Founder of Loyal, which she incorporated in 2019 at the age of 25. Loyal is a biotech startup developing drugs to increase canine healthspan.

In today’s episode, they talk about the mission and vision of Loyal and the future that Loyal is excited about. They also talked about the drugs that Loyal is developing that target extending the aging of dogs, and how Celine became an animal lover. Celine also shares that dogs are a better model of human aging in general and she also shared how they started Loyal in 2019. They also talked about the biggest thing that Celine surprised her the most when they started Loyal. Celine also shared the biggest difficulty in raising funds for a biotech company like Loyal, as well as the people that she is looking to work with at Loyal and much more! And find out what's her best advice with those who are starting a biotech company. 

Dec 09, 202230:02
Supporting the future of sustainable agriculture through soil recovery + Adrián Ferrero

Supporting the future of sustainable agriculture through soil recovery + Adrián Ferrero

Edmar Ferreira talks with Adrián Ferrero, CEO, and co-founder of Biome Makers. Adrián is a self-described entrepreneur on a mission to improve the world, and prior to Biome Makers, Adrián founded three start-ups and worked as an innovation consultant for more than nine years.

In today’s episode, they talk about the vision of Biome Makers and how they started, including the bioindicator and the science behind the technology that they are using in Biome Makers. They also talked about the ecological relationship, how their technology optimizes farming practices, and how it increases crop yield and quality, as well as improves soil health. Adrián also shared some challenges and some tips for raising capital as they closed in Series B funding stage this year and he also shared all his experiences and educational background prior to Biome Makers, and much more!

Dec 02, 202236:53
A new solution for patients with Alzheimer’s Disease to live longer + Peter Schlecht

A new solution for patients with Alzheimer’s Disease to live longer + Peter Schlecht

Edmar Ferreira talks with Peter Schlecht, CEO and Founder of Braingrade. With Braingrade, they provide direct access to our brains and improve our cognitive abilities while helping millions of Alzheimer's patients.

In today’s episode, they talk about what the future looks like with Braingrade in 20 to 25 years, and the meaning of the smart brain with Braingrade in 10 years. They also talked about the story behind Braingrade, how they started, and why Peter started Braingrade, including the technology that they have with Braingrade and how it works with the human brain, how stimulation works, and the device that they are using. Peter also shared how did they raise their fund and their upcoming rounds, and they also talked about their next clinical trial, how’s the supply chain with neurotech, what surprised Peter when he started the journey of Braingrade, and much more!

Nov 25, 202247:28
The best text and audio data labeling tool + Ivan Lee

The best text and audio data labeling tool + Ivan Lee

Edmar Ferreira talks with Ivan Lee, CEO and Founder of Datasaur. He graduated with a Computer Science bachelor from Stanford University. He has spent the last 10 years as a product manager for Machine Learning and most recently at Apple.

In today’s episode, they talk about the background of data and natural language processing (NLP), the quadrillion of documents that they generated, including how labeling works, and how every NLP team will be reliant on Datasaur in the coming years. Ivan also discussed what Datasaur provides to NLP science and how Datasaur works. They also talk about on how Datasaur works with data privacy and the software with machine learning and NLP, including the data labeling process. Ivan also shared how they started with data labeling, and how he started to build Datasaur, and Ivan also shared the most recent AI company that they acquired and much more!

Nov 18, 202240:49
Bringing artificial intelligence to health and solving a big problem for women's health + Maryam Ziaei

Bringing artificial intelligence to health and solving a big problem for women's health + Maryam Ziaei

Edmar Ferreira talks with Maryam Ziaei, CEO of iSono Health which she co-founded with the vision to make proactive and personalized breast health monitoring accessible to all women everywhere. And she has over 14 years of experience in product and business development.

In today’s episode, they talk about the vision of iSono Health, how many screenings a woman undergoes for a breast cancer screening and the technology that they are using in iSono Health. They also talked about the difference between iSono Health’s technology compared to mammograms including their biggest problem and challenges in the adoption of their technology. Maryam also mentioned the statistics of how many women die every year because of breast cancer. And she also shared how they all started, as well as the reason why she started her own start-up company and much more!

Nov 11, 202235:43
The low-temperature plasma conversion process and non-disruptive industrial decarbonization + George Skoptsov

The low-temperature plasma conversion process and non-disruptive industrial decarbonization + George Skoptsov

Edmar Ferreira talks with George Skoptsov, President and CEO of H Quest Vanguard Inc., who spent more than a decade executing and leading development of breakthrough automation and robotics technologies for the energy and mining sectors.

In today’s episode, they talk about their mission in H Quest Vanguard and how they started, what is the big problem that they’re solving now, and the possible solution. They also talked about the roots of climate change, how CO2 emissions come, and the technology they have that can address all of these problems including the biggest first example in H Quest and how they deliver the zero issue to hydrogen using their process. And they also discussed if what's the cost today of using hydrogen versus using oil and coal and the ways to decarbonize industry and much more!

Nov 04, 202255:38
Prevent resistance and induce cancer cell death + Auriane Gamelin

Prevent resistance and induce cancer cell death + Auriane Gamelin

Edmar Ferreira talks with Auriane Gamelin, co-founder, and COO of OncoXome. Where she's focused on advancing cancer research to overcome its resistance.

In today’s episode, they talk about how Auriane’s father analyzed cancer cell communication and cancer resistance, she also explained what are cancer cell communications, and cancer is an ecosystem in which cell communication is highly present. Auriane also share how did she transition from her previous industry to the biotech industry. They also talk about how they hack those exosomes, how chemotherapy works, how they perform their studies with cancer cells, what is exosome homing, and much more!

Oct 29, 202251:18
Creating a world with zero deaths from undetected cancer + Dr Sebastian Bhakdi

Creating a world with zero deaths from undetected cancer + Dr Sebastian Bhakdi

Edmar Ferreira talks with Sebastian Bhakdi, doctor, a classically trained musician, founder, and CEO of X-ZELL.

In this new episode, they talk about the vision of X-ZELL, how the Pap test started and how it works, and its effectiveness in detecting cancer cells. They also talk about the technology catching cancer cells, how they started and develop cancer screening, the different negative and positive predictive values of cancer, and the challenge they get to the first level. They also discuss the typical customer of X-ZELL and go-to-market strategy, and the knowledge and lessons that Dr Sebastian uses as a startup founder & CEO, and much more!

Oct 21, 202243:36
Treating aging and age-related disease + Simon Melov

Treating aging and age-related disease + Simon Melov

Edmar Ferreira talks with Simon Melov, a founding faculty member of the Buck Institute, the first author of a landmark paper and aging, founding co-editor of Aging Cell, and now founder and CEO of Gerostate Alpha.

In this episode, they talk about the background story of Gerostate Alpha and how they started, what are their biggest technical challenges, how do they measure the progress of their team, what are the changes in 10 years once their vision succeeded, and how they track the problem of aging, Simon’s perspective on how long will aging is treatable, and how to speed up technological progress, and all the trends that Simon is following in deep tech, and much more!

Jul 22, 202238:10
"Electrical Planes" and the future of travel + Jamie Gull

"Electrical Planes" and the future of travel + Jamie Gull

Edmar Ferreira talks with Jamie Gull, a Stanford University aerospace engineer, former SpaceX engineer, and now co-founder of Talyn Air.

In this episode, they talk about Talyn Air and how it started, the meaning of eVTOL aircraft and how it works, Jamie’s experiences in deep tech engineering and his career in aerospace, his most valuable skills as a founder, and his advice for a founder of a starting deep tech company, and some technological progress nowadays and much more!


Jun 22, 202242:01
A more sustainable global travel through new technologies + Norris Tie

A more sustainable global travel through new technologies + Norris Tie

Edmar Ferreira talks with Norris Tie, an aerospace engineer from UCLA, now CEO and co-founder of Exosonic who since a young age is been passionate about transporting people around the world faster.

In this episode, they talk about how Exosonic got started, what’s inspired Norris to figure out a way to build faster jets, the difference between hypersonic and supersonic, the challenges and solutions for supersonic flight, and the principle of the new technology for a new era of supersonic aircraft, and much more!

May 31, 202242:17
Machine learning in the mining space + Daniel Mogilny

Machine learning in the mining space + Daniel Mogilny

Edmar Ferreira talks with Daniel Mogilny, an engineer from the University of Toronto and co-founder of StratumAI, a YC-backed startup creating more accurate resource models with machine learning in the mining space.

In this episode, they talk about how StratumAI started, mining resource models, founding sales, the mining industry, books recommendations, and much more!

Apr 13, 202247:59
The future of deep tech + Guy Perelmuter

The future of deep tech + Guy Perelmuter

Edmar talks with Guy Perelmuter, an engineer specialized in computer vision techniques using artificial intelligence, author of the “Present Future: Business, Science and the Deep Tech Revolution” and founder of GRIDS Capital.

They discuss the concept and importance of deep tech, the difference between soft technology and deep technology startups, what's important to know about investing in strong deep tech companies, trends for the next years, book recommendations, and much more!

Feb 10, 202259:06
Bringing new drugs to market with machine learning + Aaron Morris

Bringing new drugs to market with machine learning + Aaron Morris

Edmar Ferreira talks with Aaron Morris, an Oxford mathematician, former data scientist, and trader, now CEO and co-founder of PostEra.

PostEra is focused on drug discovery using AI and machine learning to bring drugs to patients and new cures to diseases faster.

Edmar and Aaron talk about today’s drug discovery market, PostEra’s beginning and its Manifold software, what the daily routine of a CEO looks like, the Covid Moonshot project, Aaron’s experience at the Y Combinator program, and much more.

Feb 07, 202248:24