Authentic Biochemistry

By Dr Daniel J. Guerra

Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.

Listen on SpotifySend voice message

Available on

Report content on Spotify

Immune Cell Biochemistry.Tcell Membranes. Coda V. C.20

Authentic BiochemistryMay 09, 2024

00:00

30:00

Immune Cell Biochemistry.Tcell Membranes. Coda V. C.20

References

Cancers (Basel). 2023 Nov; 15(21): 5177 Front Oncol. 2021; 11: 750789

May 09, 202430:00

Immune Cell Biochemistry I. T cell Membrane Biochemistry. CODA-IV. C.19. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra . 07May24

References

Cancers (Basel). 2023 Nov; 15(21): 5177.

Cancer Discov. 2022 Mar 1; 12(3): 856–871

Gastroenterology. 2023 Feb;164(2): 256–271.e10.

Jagger-Richards 1966. "Ruby Tuesday" [Between the Buttons, lp.) Rolling Stones.

https://youtu.be/mAyj9q2quYc?si=fv07ARFvr0P2hEAs

Schubert, F. 1816. Symphony No. 5 in B♭ major, D. 485.

https://youtu.be/OHkot1TmvZU?si=bW0qNDjiAcqJzzvd

May 08, 202430:00

Immune Cell Biochemistry I. T Cell Membranes CoDA3/C.18 Authentic Biochemistry Dr. Daniel J. Guerra 06MAY24

References

Gastroenterology. 2023 Feb; 164(2): 256–271.e10.

Ada R. Habershon, and Charles H. Gabriel. 1907.

"Will the Circle Be Unbroken" Performed by the Carter Family incl. Johnny Cash.

https://youtu.be/JLFbUbmH7To?si=rLPSkV-mHYq3Aodf

Mozart, WA. 1783. Mass in C Minor K. 427.

https://youtu.be/KsiP4-mCnQ0?si=XoNwMiTO1JK5jPOK

May 07, 202429:43

Immune Cell Biochemistry I. T Cell Membranes c.17 Authentic Biochemistry Dr. Daniel J. Guerra 05MAY24

References

The Journal of Biological Chemistry2018 293, 19001-19011

Cell Death & Disease
volume 10, Article number: 315

Experimental & Molecular Medicine 2019. volume 51, Article number: 80.

Trends in Immunology. 2017. REVIEW| VOL. 38,Issue 4, P287-297, April 01.

Gastroenterology. 2023 Feb; 164(2): 256–271.e10

Squire/ Anderson. 1971. "The South Side of the Sky. on [ Yes -Fragile; lp]

https://youtu.be/hBAauFYod80?si=bTGJiM-dCEsHjRnJ

Mozart, WA. 1772. Symphony No. 25 in G minor, K. 183

https://youtu.be/rNeirjA65Dk?si=I8cdCyfO_FDlaBYc

May 05, 202429:54

Immune Cell Biochemistry I. T cell Membrane Biochemistry.CODA 1.Authentic biochemistry Podcast.Dr. Daniel J. Guerra

References

Gastroenterology. 2023 Feb;164(2): 256–271.e10.

The Journal of Biological Chemistry 2018 293, 19001-19011

Leitch, D. 1965 "Catch the Wind"

https://youtu.be/J8hjEYTpwE8?si=VfSaLDcP5JxzzP-p

Hendrix, J. 1967. "The Wind Cries Mary"

https://youtu.be/ARO2vbGFLJM?si=_IIEFN0BOEy6DfqW

Bach, JS. 1717. Partita in D Minor, BWV 1004

https://youtu.be/qtyTaE7LvVs?si=q7Xe7rnzDBbEx-xc

May 04, 202429:38

Immune Cell Biochemistry I. T Lymphocyte Membrane.C.15. Authentic Biochemistry Podcast.Dr Daniel J. Guerra.01May2024.

References

Trends in Immunology. 2017. REVIEW| VOLUME 38, ISSUE 4, P287-297.

FASEB J. 2020 May;34(5):6185-6197.

Couperin, F. 1714. Troisième Leçon De Ténèbres À 2 Voix

https://youtu.be/UbREakKFTow?si=JqmA1GQQpTOItUSg

Lennon-McCartney. 1970. "Let it Be"

https://youtu.be/QDYfEBY9NM4?si=nH4LJs4gprJVvcR1

May 02, 202429:46

Immune Cell Biochemistry I. T Lymphocyte Membrane.C.14 Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 30.4.24 .

References

Nutrition. 2021-11-01, Volume 91, Article 111388

Front Immunol. 2022 Jan 5:12:806529.

Cells. 2019 Aug; 8(8): 939.

Lennon-McCartney 1963."She Loves You" [Beatles Second Album; lp]

https://youtu.be/oVCwDl-S09A?si=ZjD89e5pwvXf5864

Schmelzer, JH, 1664 " Violin Sonata, in A Minor. 'Cucù'"

https://youtu.be/x1TsJFeB2x8?si=JiqwHG2GcOf2ddeT

May 01, 202429:56

Immune Cell Biochemistry I. T Lymphocyte Membrane c.13. Authentic Biochemistry Podcast. Dr .Daniel J. Guerra.28.4.24 .

References

Int J Mol Sci. 2019 Oct; 20(20): 5028

Nutrition. 2021-11-01, Volume 91, Article 111388

Bach, JS. 1720. "Brandenburg Concerto No. 6" in B Flat Major. BMV. 1051.

https://youtu.be/_tr_uYEQkrs?si=rXXWMBAnWGbEuAOk

Hunter-Garcia. 1970. "Stella Blue". [Wake of the Flood;lp]

https://youtu.be/VKsWDyvWaL4?si=DnHgzSEiiKeUOXbj

Apr 29, 202429:03

Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.12. Omega -3 fatty acids and mdiminished macrophage inflammatory gene expression. Dr. Daniel J. Guerra Authentic Biochemistry 26..4.24

References

Int J Mol Sci. 2019 Oct; 20(20): 5028.

Lennon-McCartney. 1964. "Ill Be Back"

https://youtu.be/fJSTBNTac6k?si=rr4rWE86TIs8EZcL

Bruch, M. 1866. Violin Concerto 1. G minor

https://youtu.be/9BeV9XDs64w?si=AvEAQch7T8TJrt05

Apr 27, 202428:34

A brief introduction to an epistemological dialectic directed toward research science. Dr. Daniel J. Guerra. 25.4.2924. Authentic Biochemistry Podcast

Kant, I. 1791 "Critique of Pure Reason"

Augustinus, A. 397. "Confessiones" Book 11.

Plotinus 253. "Ennead III"

Beethoven,L. 1799. Septet Es-Dur op. 20

https://youtu.be/pXsj43qCcUA?si=lWoBhVSC4WhT8uUP

Winwood-Capaldo. 1970. "Empty Pages " [Traffic: John Barleycorn Must Die,lp]

https://youtu.be/5ycyIkcX7zU?si=jUJ6U2u31_SL1vNR

Apr 26, 202430:01

Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.11. Dr. Daniel J. Guerra. Authentic Biochemistry. 24.4.24

References

Circulation. 2023.Oct 17;148(16):1231-1249.

Int J Mol Sci . 2019. Oct 11;20(20):5028.

Front Immunol. 2019; 10: 1706

Mastin, T. 1967 "How do you Feel" [Jefferson Airplane]. Surrealistic Pillow.lp.

https://youtu.be/iWUa-rKT-oY?si=1M9496MbDUBGuj0A

Hunter, Garcia, Kreutzman. 1975. "Franklin's Tower" [ Grateful Dead. Blues for Alah].lp.

https://youtu.be/55TOIJxKc74?si=2wiiTKbWjw5LQvxF

Haydn, FJ. 1790. String Quartet in D Major, Op. 64 No. 5

https://youtu.be/vNN_Kbuf7_U?si=KSfUc226hIIAmcy-

Apr 25, 202430:00

Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.10. Immune cell membrane glycosphingolipids. Dr. Daniel J. Guerra Authentic Biochemistry 23.4.24.

References

Guerra, D. 2023-24 lipid lectures

J Oleo Sci. 2011; 60(10): 537–544.

Gregorian Chants: 1100 AD. Beata es Virgo Maria

https://youtu.be/rMlWhAh2Zvc?si=B3XqzCsQYef_ee6t

Schubert, F. 1822. Schubert | Mass No. 5 in A flat major D 678

https://youtu.be/Yl5YF3PeUeI?si=AP9U_WHULnv3ItWi

Apr 24, 202429:53

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.9. The involved CH2O sequence event ontology. DJGPhD.22.4.24

References

J Am Soc Mass Spectrom. 2023 Nov 1;34(11):2481-2490

J Oleo Sci. 2011; 60(10): 537–544.

Trends Immunol. 2018 Jul; 39(7): 523–535.

Blood. 2014 Dec 4; 124(24): 3656–3665.

George, L. and B. Payne. 1970. "Truck Stop Girl". Byrds. [Untitled] lp.

https://youtu.be/fdI83TNKdX4?si=JWPrSMCHEX5G1zi9

Georgia Dobbins, William Garrett, Freddie Gorman, Brian Holland, Robert Bateman. 1961. "Mr. Postman". The Beatles. [With the Beatles ] lp.

https://youtu.be/v2Kk5IG2b8E?si=xcG0eUV54Bpo_T9H

Bach JS. ca. 1720. Violin Concerto No.1 in a minor BWV1041

https://youtu.be/Q3-5144TaYg?si=K9eYagdfdykygw9d

Apr 23, 202429:32

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.8. 20April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra.

References

Dev Cell. 2016 Jul 25; 38(2): 161–169.

J Biol Chem. 2010 Jul 16; 285(29): 22328–22337

Landes Bioscience; 2000-2013.Madame Curie Bioscience Database [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK6207/

Nat Med. 2003 Aug;9(8):1020-5

National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 107970, Fingolimod. Retrieved April 20, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Fingolimod.

Chopin, F. 1830. Piano Concerto No. 1 in E minor, Op. 11

https://youtu.be/rsOp47o2doM?si=1yD6x1KnMmXMR23X

Hunter-Garcia. 1969. "St Stephen" [performed by Grateful Dead] Live Dead lp.(1969)

https://youtu.be/xZ5TftMTPOE?si=6nUc6EiBqRPEduFr

Apr 21, 202430:01

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.7. .18April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra

References

Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8661–8666

J Exp Med. 2021 Nov 1; 218(11): e20210417

J Biol Chem. 2010 Jul 16; 285(29): 22328–22337.

Brahms. J. 1879. Violin Concerto D. Major. OP 77.

https://youtu.be/9L6a-JJCCzw?si=r7IAjxBC8ZBfDOaR

McCartney/Lennon.1967. "She's Leaving Home" on [Beatles] SPLHCB lp.

https://youtu.be/VaBPY78D88g?si=n2R4CQF6tm8TuM9h

Apr 19, 202429:47

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.6. 17April 2024.Authentic Biochemistry Podcast.Dr. Daniel J. Guerra.

References

Cold Spring Harb Perspect Med. 2020 Jun; 10(6): a034819

Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8661–8666

Blood. 2010 Jul 22; 116(3): 485–494.

Haydn, FJ. 1793. Symphony No 101 D major "Die Uhr“.

https://youtu.be/jK9EPZ3qdgU?si=GiCVxNOchDW0fKsb

Croce, J. 1970. "Time in a Bottle".

https://youtu.be/9h1davKgBYM?si=YhyPwAtno04oYBks

Apr 17, 202430:00

T lymphocyte Membrane Biochemistry I. Immune Cell Biochemistry I c.5 Authentic Biochemistry 16April2024 Dr Daniel J. Guerra

References

Front. Immunol., 2022 Sec. Microbial Immunology Volume 12

Blood 2010. Volume 115, Issue 18, 6 May: 3708-3717

Seeger, P. 1959 . Performed by The Byrds "Turn Turn Turn"

https://youtu.be/W4ga_M5Zdn4?si=ODKk_snS-5XHZvWP

Copland, A. 1944. "Appalachian Spring.

https://youtu.be/CJYVH_kZkOk?si=UUBet58ETg0PVUrB

Apr 17, 202429:52

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.4. 15April 2024. Chemokine gradients and the membrane lipid raft. Authentic Biochemistry Podcast Dr. Daniel J. Guerra

References

FEBS J. 2018 Aug; 285(16): 2944–2971.

Nature Reviews Immunology 2023. volume 23, pages 236–250.

Angiogenesis. 2021; 24(4): 719–753.

Front. Immunol. 2022 Sec. Microbial Immunology Volume 12

Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service.

https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D

Apr 16, 202429:59

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.3. 14 April 2024 .Authentic Biochemistry Podcast.Dr. Daniel J. Guerra

References

Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366

Drugs. 2016 Jul;76(11):1067-79.

Front Immunol. 2021; 12: 613591

J Appl Microbiol. 2009. Jun;106(6):1908-18

Exp Cell Res. 2015 May 1; 333(2): 195–200.

Mediators Inflamm. 2017; 2017: 4806541.

Parsons, G. McQuinn,R. 1971. Pale Blue [ Byrds] Byrdmaniax lp. https://youtu.be/Mh3J7GqrdzY?si=Kp0XfrwPtSi4vY6q

Baker, G. 1967. "Blue Condition" [Cream]. Disraeli Gears lp.

https://youtu.be/bjQjEyJwPpg?si=70Nye1AGPWsgG0hs

Strauss, J.(II). 1866 "An der schönen blauen Donau", Op. 314

https://youtu.be/fHzhDKwYP2s?si=umxkaYC6nRvikezX

Apr 15, 202429:58

Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.2 Lipid mespmorph and radius assymetry direct Tcell membrane sterol and protein interdigitation that is altered by pressure via PV=nRT.

References and simple equations

PV = nRT where P is pressure (in atm), V is volume (in liters), n is number of moles and T is temperature (in K); R is a constant and is equal to 0.08206 L atm/moleK.

Molecular Shape including thickness(radius) of membrane curvature is v/al where v=volume,a=area per headgroup, and l=thickness of the hydrocarbon monolayer

Guerra, D. Membrane Biochemistry notes

Apr 13, 202430:00

Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.1. DJGPhD.11April24.Authentic Biochemistry Podcast

References

Front Immunol . 2021 Mar 10:12:613591.

Guerra, D. 2020's. Membrane Biochemistry Lectures

Crosby, D., Kantner, P., and Stills, S. 1968. "Wooden Ships" [Jefferson Airplane ] from Volunteers lp.

https://youtu.be/ROBaoiJK0wc?si=ABsxa4m4AjjAwoms

Mendelsshon, F. 1830. "The Hebrides Overture"-Fingal's Cave.OP26.

https://youtu.be/MdQyN7MYSN8?si=w9G1d0_5DFJn-tzx

Apr 12, 202429:56

Biochemical Mosaic III. Coda. DJGPhD .09April24.Authentic Biochemistry Podcast

References

Guerra, D. 2024. The Mosaics I-III.

https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625

Beethoven, LV. 1806. Violin Concerto D Major. Op 61.

https://youtu.be/cokCgWPRZPg?si=pKKUsINChgI14PH9

Apr 10, 202430:00

Biochemical Mosaic III. c.14. From physical chemistry to the mechanisms of sphingomyelinase mediated inflammation: abrief dialectical accounting of research involving abiotic vs biological phenomena.

References

Guerra, D. 2024. Previous Lectures: Authentic Biochemistry.

https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625

Waters, R.1973. "Eclipse" from [Dark Side of the Moon]; Pink Floyd lp.

https://youtu.be/k0xGxnZFNYs?si=VrfYPQuXef41Drfm

Holst, G. 1918. "The Planets"

https://youtu.be/HP5xhyPn58U?si=IdN_iqJNvt_tjQKP

Apr 08, 202430:01

Biochemical Mosaic III.c.13. A priori intralocution of inflammasome genomic loci with stress phenomena immunoepigenetically resolves defensive inflammation. DJGPhD.6April24. Authentic Biochemistry.

References

Guerra, D. 2024 Previous Mosaic III lectures and content.

https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625

Hayward, J. 1969. "Never Comes the Day" from Moody Blues lp. Threshold of a Dream.

https://youtu.be/8u1zH11yqFQ?si=xtXp1SWm8rF1RdFS

Mozart, WA.1785. String Quartet No. 19 in C Major, K. 465

https://youtu.be/f3oK4XVMARs?si=FMypvP8O_WCII7vR

Page, J.1972. "The Rain Song" Led Zeppelin Houses of the Holy lp.

https://youtu.be/g8VduT7aR2c?si=zB2oS2kCV2t4WtEb

Apr 07, 202430:01

Biochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry Podcast

Refernces

Guerra, DJ. Inclusive non-extemporaneous reasoning on biochemical event ontologies.

Jefferson, Blind Lemon 1927, Hunter-Garcia 1969 Jefferson's "I know You Rider" and "China Cat Sunflower" . Grateful Dead. Europe 72' LP.

https://youtu.be/xCgZxrf8nrU?si=k7WGmY-fo_AjEip-

Schmelzer, JH 1664. Violin Sonatas, "Romanesca".

https://youtu.be/fB8G39y1uCA?si=hzGCK2Qq6TtIubAh

Apr 05, 202429:58

Biochemical Mosaic III. Inflamasomes c.11 A Dialectical Event Ontological conciliantus contrarion perspective.DJGPhD.3April24.Authentic Biochemistry Podcast.

REferences

Guerra, DJ. 2024. Biochemical Mosaic III lectures.

https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625

Dvorak, A. 1879. Romance in F minor, Op. 11, (B. 39).

https://youtu.be/XZTeavJ9frA?si=18LFzAQ9FKfrQ_16

Dylan, R. 1975. "Tangled up in Blue" performed by Gerry Garcia Band (live;1977)

https://youtu.be/8Aw7FW1Frjs?si=jURQC3jBWFPirSh8

Betts, R. 1972. "Blue Sky" Allman Brothers (Eat a Peach.lp.)

https://youtu.be/wwyXQn9g40I?si=15Cv6iJxR82VAb_3

Apr 04, 202429:22

Biochemical Mosaic III.c.10 Atherogenesis and neointma formation are associated with sphingomyelinase membrane raft NOX aggregation during inflammasome activation.DJGPhD.2April24

References

J Lipid Res. 2022 Dec; 63(12): 100298.

Mol Cells. 2020 Aug 31; 43(8): 749–762.

Bach J.S. 1727. St Matthew Passion, BWV 244.

https://www.youtube.com/live/3fP-rET0kFI?si=ZX-edMPg1wBA_5mh

Squire, Chris. 1978. "You Can Be Saved" Yes.

https://youtu.be/0TNzPHoVlz8?si=bFMp6w4T2SL6XxS4

Apr 03, 202429:47

Biochemical Mosaic III.c.9 Clinical associations of inflammasome mediated pathophysiology linked to epigenetic methylation patterning and DNA repair. DJGPhD.1April24.

References

Redox Biol. 2020 Apr; 31: 101482

Nat Rev Microbiol. 2009 Feb; 7(2): 99–109.

J Neuroinflammation. 2019; 16: 236.

Front Pharmacol. 2021; 12: 643254.

Biber, H. 1676. "Passagalia" por solo violin

https://youtu.be/sgcR183f8gA?si=ovfSbdg6WsfuIiTw

McBroom, A. 1976. "The Rose" Conway Twitty

https://youtu.be/cO59ITNCxzk?si=ueMmXtzMNH4YeQ_w

Hunter-Weir. 1970. "Sugar Magnolia" American Beauty L.P.

https://youtu.be/ei5EmN2HmVI?si=6ZrBBPmu3cMyMOAO

Apr 02, 202430:00

Biochemical Mosaic III.c.8. S. aureus clearance via dual pyroptosis and necroptosis salientsand the control over the hyperinflammatory axis of clinical disease. DJGPhD.31.3.24

References

Cell Reports 2016.Volume 16, Issue 8, 23 Pages 2219-2230

Front Immunol. 2020; 11: 621733

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969

Apr 01, 202429:19

Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies

References

Int J Mol Sci. 2021 Jul; 22(14): 7580.

Trends Biochem Sci. 2023 Apr;48(4):331-344

Immunology. 2020;159:142–155

Curr. Opin. Immunol. 2020;62:39–44.

Nat. Rev. Mol. Cell Biol. 2019;20:569–570.

Lennon-McCartney. 1963. "This Boy"

https://youtu.be/lW5D7HpYhBU?si=mHyiFng3rd3pukob

Lennon-McCartney.1966. "And your Bird Can Sing"

https://youtu.be/sOUlbredoUM?si=nPB64c8GS4joYx9G

Lennon-McCartney 1969. "Let it Be"

https://youtu.be/QDYfEBY9NM4?si=H6t6bwrv3vUNWoDj

Vivaldi, A. 1715 "Gloria"

https://youtu.be/RMHguvZPcqQ?si=igPXLKL9O0YbRWKz

Mar 28, 202430:00

Biochemical Mosaic III. c.6. S auereus induced inflammasome activating pyroptosis circumvents immune clearance and ARDS pulmonary chronic activation share similar hyperinflammatory presentation.DJGPhD

References

Front Immunol. 2019; 10: 1309

Immunity. 2018 Sep 18; 49(3):413–426.e5.

Front Immunol. 2020; 11: 621733

Infect Immun. 2013 Dec; 81(12): 4478–4489.

Immunity. 2023 Nov 14;56(11):2523-2541.e8.

Harrison, G. 1969. "Here Comes the Sun" Abbey Road Lp. Beatles

https://youtu.be/GKdl-GCsNJ0?si=xUqwi3Q7Ne694ruD

Mozart, WA. 1775. Violin Concerto No.3 in G major, K. 216

https://youtu.be/j7Z6gouAVCc?si=xVwtNKAWDEDdtKMV

Parsons, G. 1965 "Brass Buttons" Poco: Crazy Eyes Lp.

https://youtu.be/CpFytplzLhI?si=vw08Gut3E-otgA9x

Mar 27, 202430:01

Biochemical Mosaic III. c.5. Gal3 and NRLP3 inflammasome coordinate inflammation via IL-1Beta convertase activation that is associated with NAFLD and NASH and inhibition of ABCA1 cholesterol efflux.

References

Infect Immun. 2013 Dec; 81(12): 4478–4489

Cell Cycle. 2022; 21(11): 1121–1139.

The Journal of Nutritional Biochem.2023.Volume 112, 109217

Lightfoot, G. 1964. "Early Morning Rain"

https://youtu.be/ZFJ5Bj_put0?si=m1Ue7rFfk_ggSLR3

Simon ,P. 1968. "Old Friends" SImon and Garfunkle Bookends LP.

https://youtu.be/7A76lTte8qE?si=rfk3Q6wTA6Nsiok7

Mozart, WA. 1782 Serenade in C. Minor K.388.

https://youtu.be/R6iSGBNdqSw?si=S2eGPmcySUhw4uvU

Mar 25, 202429:21

Biochemical MosaicIII. C.4. My oppositional dialectic and episteme- metaphysical discourse on method+ Gal3 as proinflammatory lectin may not uniformly correlate with pathobiochemical events. DJGPhD.

References

Guerra, DJ. 2024. Uncollected writings.

The Journal of Nutritional Biochemistry 2023. Volume 112, February. 109217

Walker, Cindy.1950 Blue Canadian Rockies. Cover "the Byrds"(1969).

https://youtu.be/nzOHtU8Sb3c?si=5GAj7VPzIr7o0OO_t

Heinichen J. D. 1711 (?)Concerto in A minor for violin

https://youtu.be/V-E25Q-wjwc?si=bbWdZTNEUPGitY-S

Mar 23, 202430:01

Biochemical Mosaic III c.3. Bacterial glycosphingolipid mediated inflammasome activation and the Galectin:NLRP3 interaction pathophenocopy oxy-mtDNA TLR induction.DJGPhD.21.3.24

References

Front Immunol. 2020; 11: 591803

Am J Gastroenterol. 2004 Nov;99(11):2147-9.

Biochem Biophys Res Commun. 2005 Dec 16;338(2):1031-6

Front Immunol. 2019 Jun 7;10:1309.

FASEB J. 2021 May; 35(5): e21439.

Hildegard von Bingen 1150.- "Canticles Of Ecstasy

Mar 22, 202428:51

Biochemical Mosaic III. C.2 A Non-canonical autophagic inhibition of NLRP3 inflammasome mediated inflammation in UVB-treated human keratinocytes.DJGPhD. 20.3.24.

References

Front Immunol. 2019 Jun 7;10:1309.

JBC 2024 . March.Article in Press
DOI:https://doi.org/10.1016/j.jbc.2024.107173

FASEB J. 2016 Dec;30(12):4202-4213.

Nat Rev Gastroenterol Hepatol . 2020 Feb;17(2):93-110

Bach , JS. 1731. Piano Partita No. 2 In C Minor, BWV 826

https://youtu.be/f-OdOuNZciQ?si=AmFtC5CX3x2ndzdV

Slade,Mann, and Rogers. 1975 "Time is Right" Manfred Mann

https://youtu.be/jzJIej8h5q4?si=3-aCFe0tqur4lfX1

Mar 21, 202430:00

Biochemical Mosaic III. C.1. Inflammasomes. DJGPhD.19.3.24 Authentic Biochemistry Podcast

References

Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8

JBC 2024. March. Article in Press

https://doi.org/10.1016/j.jbc.2024.107173

Schmelzer. J. H.1664 Sonatae unarum fidium.

https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR

Hayward, J. 1967 "Tuesday Afternoon" Moody Blues

https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR

Hayward, J. 1970 "Question" Moody Blues

https://youtu.be/NP9iOqdxS8c?si=rfI3lzy0HhcffkWT

Mar 20, 202430:01

Biochemical MosaicII.Book2.C.13.Dialectical event ontologies involving CNS plasmalogen and sphingolipid interlocution and the universality of Mozart and the Beatles. DJGPhD.17.3.24.Authentic Biochem.

REferences

Dr. Guerra. 2024.Previous Authentic Biochemistry Mosaic II lectures in the series

Kant, I. 1790. Critique of Judgment.

Mozart, WA. 1788. Sinfonie C-Dur KV 551 (»Jupiter«)

https://youtu.be/6RbKWhr0o1c?si=xkt3QMG5aud__zLN

Beatles. 1965. "Rubber Soul"

https://youtu.be/kfSQkZuIx84?si=8QFvenLD4k8KLJD3

Mar 18, 202430:00

Biochemical Mosaic II.Book 2. c.12 Adduced mTORC mediated glycerol-sphingolipid enzyme mRNA transcriptome association with Plasmalogen apodiction of myelination.DJGPhD.16.3.24

References

Developmental Cell 2022. Volume 57, Issue 6, 28 March Pages 691-706

Cell Rep. 2014 Feb 13; 6(3): 541–552.

Dr Guerra: graduate lecture notes

Mozart, WA 1791.Requiem in D Minor, K 626

https://youtu.be/YaH3zI0bYkM?si=X1yv50zY6nKTZmV9

Lennon/McCartney.1964 "I Don't Want to Spoil the Party"

https://youtu.be/zqVDvLDLsjI?si=K1ve_5zJLZjqclsb

Mar 17, 202429:45

MosaicII,Bk.2.c.11 Squalene monooxygenase (SM) stabilization due to plasmalogen pathway fatty acid reductase deficiency promotes SM epoxidase alternate activity thus lowering24OHCHOL-LXR-myelination.

References

Dr Guerra-Graduate lipid biochemistry lectures

Biochem J. 2022 Sep 30; 479(18): 1917–1940

Front Cell Dev Biol. 2022; 10: 946393.

Nat Commun. 2019; 10: 97.

Lennon-McCartney 1965. "Ive Just Seen a Face"

https://youtu.be/m8LbJfC0SYM?si=gl_URu_yPTn9iZSd

McShee, J./Traditional/Pentangle.1969 "Light Flight"

https://youtu.be/2tyVezuUtCA?si=THxBJ0reUETkwDLa

Mozart, WA. 1785.Piano Concerto No. 21 in C Major, K. 467

https://youtu.be/whTEVQ2OizI?si=YDMhOhlwmpKYqK-t

Mar 14, 202429:53

Biochemical Mosaic II. Book2. c.10.Plasmalogen mediated oxy vs epoxy sterol synthesis may control cns inflammation and myelination given acid-catalyzed transacetalization sequalae.DJGPhD.12March24

References

Front Cell Dev Biol. 2022; 10: 946393.

Adv Exp Med Biol. 2024:1440:149-161

Mozart, WA..1786.Horn Concerto in E-flat major # 4 KV 495

https://youtu.be/MMjqU461WpI?si=o2OWIijoe-mbF-pM

Sebastian, J. 1968 She's a Lady

https://youtu.be/xyFdzevDOHg?si=wgmv5z_jGrtA9x7c

Mar 13, 202429:29

Biochemical Mosaic II. Book2. c.9. Plasmalogen regulation of composite ruling over prescriptive organization of cellular-biochemical phenomena includes florid mediation of the CNS.DJGPhD.11MARCH2024.

References

Journal of Cell Science 2019.Vol.132(6), 223016.

Brain Research Bulletin 2023.Volume 194, March. Pages 118-123.

Beethoven, LV. 1806. Violin Concerto D major, Op. 61

https://youtu.be/_hXdjRYELGw?si=0q5_qJCZu_zAZWoE

Berry, C. 1956. "Roll Over Beethoven" ; as performed by the Beatles 1963 on LP "With the Beatles"

https://youtu.be/Hz5jXwOXgKQ?si=FASk6PG2SAsEkrvP

Mar 12, 202429:39

Biochemical Mosaic II.c.8 Cell death and CE-circ RNA vs.miRNA in Hepatocellular carcinoma: the spectre of AGPS et al. DJGPhD. 10March24.Authentic Biochemistry.

References

Cell Death Dis. 2020 Dec; 11(12): 1065.

Genome Res. 2000 Oct; 10(10): 1445–1452.

https://www.genecards.org/cgi-bin/carddisp.pl?gene=NIPBL

Genes Dis. 2022 Jan; 9(1): 116–127

Schubert, F. 1824. Quartet 14 in D minor, D 810, "Death and the Maiden"

https://youtu.be/XF_6vSlmm4w?si=CGTn3R6Tkn6LsMLv

Browne,J. 1993. "Sky Blue and Black".

https://youtu.be/Ty1I6dtC2zc?si=QHuwDiQUDh-4S5VP

Mar 11, 202429:49

Biochemical Mosaic II.c.7. Fatty acid desaturation and mole% PC/PE/PL/CER are elevated via circRNA in Medublastoma while AGPS increased circRNA's in thyroid cancer.DJGPhD.7Mar24. Authentic Biochem.

References

Acta Neuropathologica Communications 2023. volume 11, Article number: 38

Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7792–7798

Front Mol Biosci. 2022; 9: 925389.

Front Cell Dev Biol. 2021; 9: 636838

Oncol Lett 2018. 15: 7889-7899.

Saint-Saëns, C. 1886. Symphony No 3 in C minor, Op 78

https://youtu.be/ZWCZq33BrOo?si=8hQ01E9jfp0eU07o

Winwood,S. 1969. Had to Cry Today (Blind Faith)

https://youtu.be/Z4Yo_VbGdMg?si=tWz0_qnG5Nsx5qxX

Mar 08, 202429:50

Biochemical Mosaic II.c.6 Meduloblastoma is linked to plasmalogen and circ RNA phenomena that are pathophenocopied in other cancers. DJGPhD.5.Mar24.Authentic Biochemistry

References

Acta Neuropathologica Communications 2023. volume 11, Article number: 38

Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7792–7798.

Int J Med Sci. 2022; 19(6): 975–985

Nature Communications 2022. volume 13, Article number: 1508

Lassus. O. 1578. Requiem - Missa pro defunctis (4vv) : Offertorium

https://youtu.be/UXY4hxCvu7M?si=lcM_lw11lbPWrYX4

Mar 06, 202430:01

Biochemical Mosaic II. c.5 Peroxisomal plasmalogen biosynthesis may regulate transcriptomic and proteomic sequalae to plasmamembrane mediated signal transduction. DJGPhD.4March24.

References

Front Physiol. 2021; 12: 730829.

Non-coding RNA Investig 2017. 1:5.

Genome Biology 2011. volume 12, Article number: 236

RNA Biol . 2021 Nov 12;18(sup2):574-585.

Hunter. R. 1975. "Cruel White Water"

https://youtu.be/T-oBD3F74Nk?si=zsrEBN0JKan_FXdH

Mar 04, 202430:00

Biochemical Mosaic II. c.4. Peroxisomal biogenesis and AGPS-mediated plasmalogen synthesis involve circular RNA species that alter microRNA and mRNA expression in human cancers. DJGPhD.3MAR24.

References

Genome Res. 2004 Nov;14(11): 2245–2252.

Int J Med Sci. 2022; 19(6): 975–985.

Oncol Lett. 2018 May; 15(5): 7889–7899.

Cell Death Dis. 2020 Dec; 11(12): 1065.

RNA Biol . 2021 Nov 12;18(sup2):574-585

Bach, J Christian. 1775. Sinfonie Concertante

https://youtu.be/S8NPgouJ5uk?si=_azSWNelNFRA2ai5

Mar 04, 202429:49

Saturday Night Authentic Biochemistry The Agentic operator as metaphysical metaphor in metabolic regulation. DJGPhD.2March 2024.

References

Dr Guerra Archives: Graduate Biochemistry Lecture notes and syntheses

Simon, P. 1969. The Boxer.

https://youtu.be/l3LFML_pxlY?si=Nv5-mSzRu6fHP8Sr

Boccherini, L. 1760. 7. Cellokonzert

https://youtu.be/NSU6Ylxaobs?si=PZW0S3mWl25RwnE2

Mar 03, 202430:00

Biochemical Mosaic II. c.3 Plasmalogen metabolism is coherently associated with peroxisomal integrity and replication. DJGPhD.01March 2024 Authentic Biochemistry.

References

Oncol Lett. 2018 May; 15(5): 7889–7899

Nat Genet. 1997 Apr;15(4):369-76

Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118609

Protein Cell 2018. 9, 196–206

Brain Research Bulletin 2023. 194: 118–123

The Moody Blues. 1968. "In Search of the Lost Chord"

https://youtu.be/k5UdP-SFNgY?si=zDboUgA2LDi3E7m1

Mar 02, 202430:01

Biochemical Mosaic II. C.2. Plasmalogen and PAF biosynthesis in relation to glycerol lipid and intermediary subcellular metabolism.DJGPhD.27.2.24

References

Guerra: graduate biochemistry lectures

Chopin, F. 1830. Nocturne E Flat Major Op.9 No.2

https://youtu.be/tV5U8kVYS88?si=MKxfguVRI6hhQeMO

Winwood, Wood and Capaldi 1967. Dear Mr Fantasy. Traffic.

https://youtu.be/sS_eHdqcrM8?si=95X9RWJD2Q4w456S

Feb 28, 202429:59

Biochemical Mosaic II. Plasmalogens & other ether lipids. c.1 DJGPhD.26.2.24. Authentic Biochemistry Podcast

References

Cell Metab. 2014 Mar 4; 19(3): 380–392.

Protein Cell 2018. 9, 196–206.

Membranes 2023, 13(9), 764.

Debussy , C. (. 1890;1905) Clair de lune.

https://youtu.be/6zzWnxuQPWI?si=gcEAKpbgc9xO8esf

Morricone. E. 1968. "Once Upon a Time in the West"

https://youtu.be/j5eQ9UTmDLo?si=-eUjJ1s9hAd6fpwz

Schubert, F. 1825. Ave Maria

https://youtu.be/2H5rusicEnc?si=LcYisCODwtGgjjVx

Feb 26, 202429:37