Gene repression with the efficiency and specificity of CRISPR in yeast is no longer a dream! In this episode of Genetics in your world, Dr. Ishikawa tells us about how he and colleagues adapted CRISPR interference for fission yeast, allowing controllable reversible and efficient transcriptional repression. Check out the paper,— “Implementation of dCas9-mediated CRISPRi in the fission yeast Schizosaccharomyces pombe,”—that was published in the February 2021 issue of G3.
In this episode of Genetics in your world, we speak with Dr. Richard Gomulkiewicz about the evolution of gene drive resistance. With the discovery of CRISPR-Cas systems, scientists realized that they could engineer gene drives for a number of different applications. Using alleles with an “unfair” transmission advantage, we can design gene drives to help eradicate malaria vectors, agricultural pests, or even invasive species. Check out the paper, “Evading resistance to gene drives,”which was published in the February 2021 issue of GENETICS.