Live Longer World

All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad 

Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!   

There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.   

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ 

Find me (Aastha) on Twitter: https://twitter.com/aasthajz 

DR. STEVEN AUSTAD LINKS: 

Website: https://www.stevenaustad.com/

Twitter: https://twitter.com/StevenAustad

Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad 

CONNECT WITH AASTHA, LIVE LONGER WORLD: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/aasthajz

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/aasthajz/ 

TIMESTAMPS: 

0:00 Training lions 

7:15 Learning from Long-lived species 

9:55 Bowhead whales live 200 years 

12:55 House sparrows & longevity 

14:40 Study "successful" animals 

18:10 Naked Mole Rats 

20:45 What do bowhead whales die from? 

26:05 Why do ocean animals live longest? 

31:05 Beyond Caloric Restriction 

36:00 Intermittent Fasting & Circadian Rhythm 

42:40 Caloric Restriction for Healthy people? 

46:24 Will coffee shorten your life? 

49:43 The Blue Zone Myth 

55:50 Young Blood, I can't get you of out my Mind 

1:00:26 Hormones & Health (Growth Hormones for longevity?) 

1:05:18 Sex differences in longevity 

Episode Show Notes: https://livelongerworld.substack.com/p/saustad 

POPULAR EPSIODES: 

- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA

- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg

- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8

- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8

- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo 

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  Aging is universal. Let's unite in this fight. Stay in good health - Aastha.  

All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 

Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. 

This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode!  

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ 

Find me (Aastha) on Twitter: https://twitter.com/livelongerworld 

SUPPORT LIVE LONGER WORLD: 

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

DOM D'AGOSTINO LINKS: 

KetoNutrition: https://ketonutrition.org/

Website: https://linktr.ee/Domdagostino

Twitter: https://twitter.com/DominicDAgosti2

CONNECT WITH AASTHA, LIVE LONGER WORLD: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

TIMESTAMPS: 

0:00 Ketogenic diet is not optimal for everyone 

0:56 Dom D’Agostino Intro 

1:29 Plant-based ketogenic diet 

3:20 Ketogenic diet & brain protection against seizures 

16:40 Ketone Esters & Salts 

19:29 Does the brain need glucose? 

21:37 Intermittent Ketosis & Fasting Mimicking Diet 

25:17 Cyclic Ketogenic diet for longevity 

28:40 Devices for tracking ketosis 

30:30 Ketogenic diet for longevity vs. Caloric restriction 

37:50 Keto diet for cancer prevention 

41:57 Keto diet, Insulin pathway, and glucose 

46:50 Time restricted eating benefits 

50:17 Dom vs. Layne Norton on Joe Rogan podcast 

51:40 Muscle for longevity (especially for women) 

56:10 Support Live Longer World

Episode Show Notes: https://livelongerworld.substack.com/p/dom1

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  

Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple

Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. 

Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.

It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!  

Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/

Find me (Aastha) on Twitter: https://twitter.com/livelongerworld 

SUPPORT LIVE LONGER WORLD: 

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium

Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

SAM APPLE LINKS: 

Ravenous book: https://amzn.to/3yT9qpd

Website: http://www.samapple.com/

Twitter: https://twitter.com/Sam_Apple1

CONNECT WITH AASTHA, LIVE LONGER WORLD: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

TIMESTAMPS: 

0:00 Cancer as a disease of modern societies 

1:27 Otto Warburg & the Cancer-Metabolic Connection 

2:27 Warburg’s research on respiration 

4:02 Why was cancer skyrocketing in Western societies? 

9:17 Warburg Effect: Warburg’s research on cancer cells 

15:00 Why do cancer cells take up so much glucose? 

17:44 Cancer-Diet Connection 

21:44 Cancer, Ketogenic diets & Fasting 

23:43 Hibernation of the metabolic story of cancer 

27:20 Hitler’s connection with cancer 

30:07 Warburg’s arrogance 

31:51 Why does cancer need glucose? 

38:46 Warburg’s stigma: connecting with Nazi’s 

40:51 Is insulin responsible for cancer? 

48:00 Science is not immune from politics 

50:24 Prostate cancer & obesity 

52:13 Pendulum swing in cancer research 

54:40 Mitochondria & Cancer Connection 

57:07 Nazi’s fixation on cancer

Episode Show Notes: https://livelongerworld.substack.com/p/sapple 

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. 

You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.

Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab.  We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.   

Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.  

It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!  

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld

Find me on Twitter: https://twitter.com/livelongerworld 

VADIM GLADYSHEV LINKS: 

Website: https://gladyshevlab.bwh.harvard.edu/2022 

Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium 

TIMESTAMPS: 

0:00 Vadim Gladyshev Intro 

1:28 Live Longer World 

2:17 Selenium’s dual role in aging (the good, the bad, the ugly) 

11:27 Antagonistic Pleiotropy 

13:53 Selenium & Cancer 

15:58 Selenium Dosage (don’t get too much!) 

18:30 Reactive Oxygen Species, Antioxidants & Aging 

22:30 Fundamental basis of Aging 

24:09 Aging is damage 

29:20 Single cell Epigenetic Clocks 

34:22 Aging in the Womb 

42:16 Parent’s lifestyle for aging in embryo 

44:14 Rapamycin during development 

49:06 Other compounds 

51:53 Slowing Aging vs. Rejuvenation 

56:08 New projects being worked on 

57:17 Confidence level in extending lifespan within 30 years 

59:17 Support Live Longer World  

Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev 

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

Thanks for watching & if you enjoy the episode, let's spread the message on longevity.   

You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.

Aging is universal. Let's unite in this fight. Stay in good health - Aastha.

Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.  In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more.   

If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you. 

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium  

Support on Patreon: https://www.patreon.com/livelongerworld 

One-Time support: https://www.paypal.com/paypalme/livelongerworld  

ETHAN WEISS LINKS: 

Website: https://profiles.ucsf.edu/ethan.weiss 

Twitter: https://twitter.com/ethanjweiss  

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/ 

Twitter: https://twitter.com/livelongerworld 

Newsletter: https://livelongerworld.substack.com/ 

Instagram: https://www.instagram.com/longevityfuture/ 

Patreon: https://www.patreon.com/livelongerworld 

YouTube: https://www.youtube.com/c/LiveLongerWorld 

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS: 

0:00 Welcome to Live Longer World 

0:44 Misconceptions of heart disease / young people with heart disease 

4:01 Predictors of heart disease 

6:59 LDL vs HDL; Triglycerides 

12:51 Small-dense LDL vs. Large fluffy LDL 

16:09 Dietary Carbohydrates & heart disease risk 

25:50 Inflammation & Cardiovascular risk 

26:43 Lipoproteins, ApoB, Lp(a) 

31:31 Statins, PCSK9 inhibitors 

32:45 ApoB as gold standard risk marker 

36:50 Triglycerides & Insulin resistance 

40:00 Saturated Fat 

42:42 Variation in Cholesterol measurement 

46:03 Body composition as marker for heart disease risk 

51:23 Ketogenic diets & heart health 

56:43 Keyto breath sensor 

1:01:46 Stress & heart disease 

1:04:44 Growth hormone & heart disease 

1:07:46 On the shortness of life 

1:10:52 Support & Connect with 

Live Longer World  Episode Show Notes: https://livelongerworld.substack.com/p/eweiss

 Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. 

Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.

Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.  

In today’s episode, you will learn: 

- The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin 

- 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril 

- Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin 

- Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more 

- Richard’s thoughts on lifespan vs. healthspan  

All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

RICHARD MILLER LINKS: 

Website: http://www.richmillerlab.com/

Photography: https://richardmiller.zenfolio.com/

Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS: 

0:55 Richard Miller Intro 

1:51 Richard Miller Wildlife photography 

3:30 ITP - the gold standard for testing longevity drugs & winning drugs 

10:51 Rapamycin, Rapamycin + Acarbose 

18:48 Rapamycin + Acarbose Dosing Schedule 

20:15 Combination of drugs, Rapamycin + Metformin 

21:56 17-Alpha Estradiol 

25:45 Canagaflozin 

31:34 Does Richard take the 4 winning drugs? 

32:46 3 Drugs that have small lifespan effects & promising 

36:30 GPLD-1 & shared mechanisms in longevity drugs 

44:04 Resveratrol in ITP 

46:27 NR, NMN 

52:34 Curcumin, Green Tea Extract, MCT Oil 

54:54 Fisetin & Senolytics 

56:12 Why most published research findings are false 

1:00:03 Healthspan biomarkers at the ITP 

1:02:38 Can you have healthspan without lifespan? 

1:07:37 Fish Oil, Spermidine, Sulforophane 

1:12:13 Unpublished data Richard is excited about 

1:17:47 Flying Pigs & Aubrey De Grey 

1:20:00 Exponential rise in aging research

Episode Show Notes: https://livelongerworld.substack.com/p/rmiller

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

Aging is universal. Let's unite in this fight.

Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.   

Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today’s episode!  

As a last point to Yuri’s introduction, because I’d be remiss if I didn’t mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth.  

In today’s episode, you will learn: 

- The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair’s theory The Weak Epigenetic Theory of Aging) 

- Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state  

- What is it and what are the open questions in the field 

- What are the cancer risks associated with it 

- Why Yuri believes in Cryonics 

- Why Yuri got interested in uncovering the COVID-19 Lab Leak theory  

- Pharma in Russia

If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin  

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  

Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium  

Support on Patreon: https://www.patreon.com/livelongerworld 

One-Time support: https://www.paypal.com/paypalme/livelongerworld

YURI DEIGIN LINKS: 

Twitter: https://twitter.com/ydeigin

LinkedIn: https://www.linkedin.com/in/yurideigin/

Medium: https://yurideigin.medium.com/

YouthBio Therapeutics: https://youthbiotx.com/ 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon: https://www.patreon.com/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS: 

00:00 "We're not crazy" 

0:37 100% life extension & translation to humans 

4:28 Aging is potentially an engineering problem 

12:45 Strong Epigenetic Theory of Aging 

19:26 Epigenetic Reprogramming 

29:00 Risk of Cancer with Epigenetic reprogramming 

33:00 Rejuvenation without cancer risk? 

38:30 Why Cryonics Makes Sense 

48:00 COVID Lab Leak Theory 

53:45 Pharma in Russia 

58:40 Optimism in Longevity 

1:00:50 Aging is Universal. Let's Unite in this Fight

Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin

Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. 

Aging is universal. Let's unite in this fight. 

Stay in good health - Aastha.

My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease. 

In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinson’s. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company.   

Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium 

Support on Patreon: https://www.patreon.com/livelongerworld

One-Time support: https://www.paypal.com/paypalme/livelongerworld 

ANDY LEE / VINCERE BIO LINKS: 

Vincere Website: https://vincerebio.com/

Andy Lee Twitter: https://twitter.com/andy_d_lee

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon page: https://www.patreon.com/livelongerworld

Podcast All Platforms: https://anchor.fm/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Apple Podcasts: https://apple.co/3eZAoAp

Spotify: https://spoti.fi/3eZB6O5

Google Podcasts: https://bit.ly/3HN0keG

Premium Subscriber Benefits: https://www.livelongerworld.com/premium

TIMESTAMPS: 

0:00 Live Longer World Intro 

0:34 Andy Lee & Vincere Bio Intro 

1:55 Vincere & the connection between mitochondria & Parkinson's 

7:39 Mitophagy & Parkinson’s disease 

16:29 Role of USP30 in Mitochondria & Parkinson’s 

22:26 Vincere small molecules testing 

25:18 Other pathways affected during Parkinson's 

30:53 Computation Biology Platform used by Vincere 

36:50 Urolithin A & Coq10 to help with Parkinson’s 

39:45 Biomarkers for Mitophagy 

42:46 Too much mitophagy? 

44:50 Challenges running a biotech company 

48:19 Path forward for Vincere 

49:36 Support, share and follow Live Longer World!

Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science!   

Key points summarized in the show notes for premium subscribers include: 

1. The connection between Mitochondrial quality control & Parkinson’s disease 

2. Mitophagy and the science behind targeting the mitochondria 

3. Overview of the Biological Simulation Platform used by Vincere Bio 

4. Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinson’s 

5. Challenges with running a Biotech Co.

Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium

Ep. Show notes: https://livelongerworld.substack.com/p/alee

My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas!   

Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage.   

Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8).  

I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people.   

This is a shorter episode and I hope you learn more about the importance of micronutrients!  

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames  

RELATED WRITING: 

My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames 

My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods  

Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

Find me on Twitter: https://twitter.com/livelongerworld

Support on Patreon: https://www.patreon.com/livelongerworld 

DR. BRUCE AMES LINKS: 

Website: http://www.bruceames.org/ 

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

Twitter: https://twitter.com/livelongerworld

Newsletter: https://livelongerworld.substack.com/

Instagram: https://www.instagram.com/longevityfuture/

Patreon page: https://www.patreon.com/livelongerworld

Podcast All Platforms: https://anchor.fm/livelongerworld

YouTube: https://www.youtube.com/c/LiveLongerWorld

Apple Podcasts: https://apple.co/3eZAoAp

Spotify: https://spoti.fi/3eZB6O5

Google Podcasts: https://bit.ly/3HN0keG

Premium Subscriber Benefits: https://www.livelongerworld.com/premium 

TIMESTAMPS: 

00:00 Live Longer World 

00:36 Bruce Ames Intro 

1:50 Micronutrient triage theory 

5:40 Micronutrient deficiencies & age acceleration 

9:10 Vitamin D for healthy aging 

12:26 CHORI Bar 

14:46 Measuring micronutrients (blood finger-prick) 

16:55 Bruce Ames diet 

18:19 Asthma caused by obesity / bad diet improved by CHORI bar 

21:21 Dr. Ames lifestyle over the years 

22:47 Importance of zinc 

24:15 Nutrition is complicated 

24:44 Dr. Ames last words & advice for young scientists

Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.

My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research.  Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity. 

In today's discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.  

All platforms / Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/bkennedy 

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DR. BRIAN KENNEDY LINKS: 

Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/

Twitter: https://twitter.com/BKennedy_aging 

LIVE LONGER WORLD LINKS: 

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DR. BRIAN KENNEDY RESEARCH DISCUSSED: 

2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/ 

2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/ 

2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/ 

2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/ 

2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/ 

2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081

Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share!  Stay in good health - Aastha.

My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. 

Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They’ve also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!!   

Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in today’s episode.  

Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution

Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium 

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast 

DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/  

2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/  

2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/  

2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082  

LIVE LONGER WORLD LINKS: 

Website: https://www.livelongerworld.com/

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TIMESTAMPS: 

00:00 Live Longer World Intro 

00:35 Irina & Michael Conboy Intro 

1:08 Aging is slowdown in our repair machinery 

2:55 Naked Mole Rats not extreme model for longevity 

5:37 Heterochronic Parabiosis 

16:00 Young Blood to Old Blood Exchange 

19:19 Rejuvenation via Neutral Blood Exchange (NBE) 

22:56 Old Blood Degenerates Young Mice 

25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE 

27:16 How long do effects of NBE last? 

30:15 How is NBE working mechanistically? 2 waves of rejuvenation 

33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative 

38:12 NBE vs. Senolytics 

40:53 Unanswered Questions on NBE 

43:13 Oxytocin & Muscle Functioning; Notch Signaling 

48:12 Chickens & Ravens as Pets!  

Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.

Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. 

Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today’s episode and also in his book Age Later.  

He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.  

In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage. 

Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai

FOLLOW NIR BARZILAI:  

Profile: https://einsteinmed.edu/faculty/484/nir-barzilai/  

Twitter: https://twitter.com/NirBarzilaiMD  

Book: https://us.macmillan.com/books/9781250230867  

FOLLOW LIVE LONGER WORLD:  

Website: https://www.livelongerworld.com/  

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My guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that!

Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah including Oisin Biotechnologies, the concept of longevity escape velocity, his work with the super centenarian research foundation, how one can get involved in funding longevity companies and more.

I hope you enjoy the episode!

TIMESTAMPS:

0:00 Live Longer World Intro

1:30 David Gobel & Methuselah Foundation Intro

2:00 Dave's work at the TSA; Innovation at TSA

10:39 Methuselah Fund, How Dave got interested in Longevity & met Aubrey De Grey

19:14 The current healthcare system does not focus on preventative medicine; Aging is the biggest risk factor for all diseases

20:40 Methuselah Foundation mission - Making 90 the new 50 by 2030

26:56 Companies funded by Methuselah - Turnbio, Epigenetic reprogramming, Organovo 3D Tissue Printing

30: 18 Leucadia Therapeutics & working to erase Alzheimer's disease

37:20 Donating to Longevity

38:24 Investing in Longevity - how to get started

40:20 Vascular Tissue Challenge with NASA

43:05 Longevity Escape Velocity

47:28 Challenges in the Longevity Field (Money comes to winning solutions & ideas!)

51:55 Do we use money or does money use us?

57:00 Ending remarks

FOLLOW LIVE LONGER WORLD:  

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Store: https://www.longevitystore.co/  

FOLLOW METHUSELAH FOUNDATION:  

Website: https://www.mfoundation.org/  

Twitter: https://twitter.com/mfoundation

"Can I really live to be 200? Can I feel like I’m 20 when I’m 70? Can aging be reversed? Hold up, what even is aging? Now I’m curious to know about aging and longevity science!"

Well then, you're at the right spot! Hello and welcome to Live Longer World!

The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. We take you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future.

To stay informed on what the future of aging and longevity looks like, make sure to subscribe to Live Longer World at Apple podcasts, Spotify, YouTube or wherever you get your podcasts. We look forward to transforming how we age in the future and bring you along on this wonderful journey.