The DeSci Podcast

In this episode, we discuss the problem of declining R&D efficiency with Dr. Jack Scannell, a scientist and entrepreneur who is well known for coining the term “Eroom’s law,” which highlights the decline in pharmaceutical research and development (R&D) productivity over several decades.

In this episode, Jack sheds light on the root causes of this decline, beginning with a critique of the poor quality of diagnosis surrounding the R&D productivity problem.

He also talks about the challenges in accurately measuring progress in drug research, highlighting the "measurement problem" in the drug industry. Jack suggests adopting a model akin to the "Stern Review” to improve the diagnosis of these challenges.

Jack also addresses topics such as the shift in the frequency of serendipitous drug discoveries, the Eroom’s law article, the entanglement of science, money and drug development and many more.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

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⭐ Timestamps:

0:00 Intro

01:40 Poor quality of diagnosis of the R&D productivity problem

04:01 The measurement problem

09:21 Chesterton’s fence of R&D

14:38 Science, Drug development, Money.

20:46 The role of Serendipity in drug discovery

26:34 Economics in the drug industry.

34:43 Implicit knowledge within Biotech

41:43 Eroom's Law paper

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If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Lea Degen: https://twitter.com/lealeata

Jack Scannell: https://twitter.com/JackScannell13

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Jeffrey Koury, Director & Business Development Lead at ResearchHub, and Jonathan Heppner, Marketing & Social Media Lead.

ResearchHub is a platform designed to accelerate the pace of scientific research by providing a modern mobile and web application where people can collaborate on scientific research more efficiently. It aims to make scientific research accessible, collaborative, and prioritized for everyone.

In this episode, we delved into the shortcomings of the current scientific research model and the need to make science open to everyone.

Our dialogue centered on advocating for a shift from the traditional model towards a more inclusive and transparent system. Central to this shift is the necessity of building better incentive structures, which would drive collaboration among scientists and facilitate accelerated progress in scientific research.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

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⭐ Timestamps:

0:00 Intro

1:30 What is Research Hub?

03:05 Onboarding process.

05:40 What drove your interest in building Research Hub?

12:16 Past efforts in promoting open science

18:32 The role of Research Hub in scientific literature

26:19 How Research Hub differs from traditional journals

35:14 Public versus Anonymous Peer Review

39:20 Most contentious topics within your field

48:50 Ensuring high quality science

52:35 Why books are important

59:13 How to get involved

59:47 How Research Hub has evolved over the years

1:05:13 Outro

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If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Lea Degen: https://twitter.com/lealeata

Jeffrey Koury: https://twitter.com/jeffyfish9

Jonathan Heppner: https://twitter.com/EnactJohnny

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Today we are delighted to host Seemay Chow, Co-founder and CEO of Arcadia Science, a for-profit research institute with a specific focus on novel model organisms that haven't been traditionally studied in the lab and translating discoveries into commercial ventures.

In this episode, we discuss Arcadia’s mission, structure and approach, emphasizing the importance of providing scientists with the context needed to understand the practical applications of their research. Seemay explains how this approach fosters a different kind of creativity among researchers, thus increasing the likelihood of research success.

We also explore the limitations researchers face in the traditional setting while further highlighting the strengths and weaknesses of Academia and industry. Other topics we touched on include notions of diversity in science, strategies for spotting the best talents and ideas to fund, and many more.

Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below.

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⭐ Timestamps:

0:00 Intro.

0:49 Effects of running a for-profit venture on Arcadia’s structure.

3:05 What is Arcadia?

7:35 Researchers limitations in Academia.

11:45 Academia vs the private sector.

16:21 Insights gained from building Arcadia.

27:54 Arcadia structure.

30:38 Diversity in science.

35:24 Strategies for discovering the best talents.

43:28 Contextualizing science.

49:50 Outro.

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Lea Degen: https://twitter.com/lealeata

Seemay Chou: https://twitter.com/seemaychou

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci podcast. Today, we were joined by Alfred Brown, co-founder of Desci London, a community dedicated to transforming science through web3 technology. In this episode, we talked about the DeSci London conference (scheduled for Saturday, 23 Mar 2024, 09:30 - Sunday, 24 Mar 2024, 16:30 GMT). This two-day event aims to spotlight the transformative potential of blockchain technology in the field of science, covering agendas such as Longevity research, Rare diseases, DeSci Tooling and Infrastructure, Climate tech innovations, Women’s health, and more. Alfred shares insights into the event's objectives, potential speakers, and details on how to livestream for those unable to attend in person. In addition to the main discussion, we explored the intersection between web3 and science, the importance of community in Desci, and several other topics. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 0:00 intro 1:16 Alfred’s journey into DeSci. 04:57 What was your experience diving into blockchain as a beginner? 07:12 Recommendations for scientists venturing into DeSci. 11:34 DeSci London event. 16:55 How to apply for the travel grant. 22:38 The role of art and creativity in science. 28:33 Community-building in DeSci. 29:54 How to find the DeSci London monthly meetups. 30:46 Insights for aspiring Desci community builders. 37:22 Potential speakers for the event. 45:36 How to live stream the DeSci London event. 49:29 Other notable DeSci events. 52:23 Impact of younger generations in DeSci. 56:00 Molecule and Nucleate partnership. 58:48 The necessity of community in Desci. 1:08:09 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to Special thanks to Ella McCarthy-Page: https://twitter.com/EMcCarthyPage Alfred Brown: https://twitter.com/AlfredJBrown99 ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! Today, we are delighted to host Stuart Buck. Stuart serves as a Senior Advisor at the Social Science Research Council and is the Executive Director of the Good Science Project—an organization dedicated to enhancing the funding and practice of science.

In this episode, Stuart addresses key challenges in the scientific landscape, such as bureaucratic obstacles to funding and the distinction between basic and applied science.

He emphasizes the interconnected nature of basic and applied research, highlighting how discoveries from basic research lay the foundation for applied innovations and challenges addressed through applied science inspire new questions in basic research.

Moving further, Stuart shares his view on the metaphor of failure in science. According to him, failure is not synonymous with defeat; instead, encountering failures in scientific endeavors indicates that one is posing pertinent questions and pushing the boundaries of knowledge.

Other topics covered in the podcast include scientific reproducibility, the measurement problem in science, enforcing data accessibility, and many more.

Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below.

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⭐ Timestamps:

0:00 Intro

01:27 Good science project main focus.

03:37 Stuart’s theory of social change

10:04 Areas that need improvement

13:00 Recommendation for young researchers

17:35 Why grantmakers tend to be conservative in funding basic science

21:45 Basic vs Applied research

24:15 The notion of failure in science

30:59 Revisiting anti-portfolio

37:37 The value of funding replication in research

43:45 The problem with metrics

46:49 Outro

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If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Lea Degen: https://twitter.com/lealeata

Stuart Buck: https://twitter.com/stuartbuck1

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast!

Today we were joined by Brian Margierski, Brian is the CEO and Founder of Cerebrum DAO, an open, global community that seeks to reimagine impact funding to advance brain longevity and accelerate solutions and cures to Alzheimer’s disease and other neurological disorders.

In this episode, Brian delves into Cerebrum DAO, outlining its mission and commitment to advancing brain health research. He sheds light on the motivating factors behind his interest in this field and elaborates on why he opted for the DAO model as the most fitting framework to achieve these objectives.

We also discuss how the DAO model enables entrepreneurship by creating an environment for innovation and empowering individuals to propose and pursue unconventional projects without the constraints typically associated with centralized funding models.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

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⭐ Timestamps:

0:00 Intro

01:04 Cerebrum DAO’s mission

02:54 What drove your interest in brain health research?

07:05 What made you choose the DAO model?

13:37 Cerebrum DAO structure.

18:14 Collaborating with biotech companies

20:37 Maintaining scientific quality in decentralized funding

24:50 How DAOs enables entrepreneurship

30:12 Contentious topics in your workplace.

32:05 How to get involved.

35:05 Outro

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Lea Degen: https://twitter.com/lealeata

Brian Magierski: https://twitter.com/bmagierski

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

In this episode, we're joined by Keith Comito, a computer programmer, mathematician, and President at Lifespan. Lifespan.io is a non-profit advocacy foundation dedicated to accelerating initiatives aimed at addressing age-related diseases and extending the healthy human lifespan.

Extending the human lifespan has been a captivating and often controversial topic. Over the years, focus has shifted from merely treating end diseases to addressing the fundamental mechanisms of aging itself.

In this episode, Keith shares with us the factors that inspired his commitment to work on aging research. We also discuss how societal attitudes on extending lifespan have changed over the years and the philosophical implications of infinite lifespan.

In conclusion, Keith underscores the paramount importance of attaining the goals of aging research, emphasizing the positive impact such accomplishments would have on the well-being and advancement of humanity.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

___

⭐ Timestamps:

0:00 Intro

01:09 About Keith

02:09 What drew you to work on Lifespan.io

03:05 The relevance of studying history in Tech

07:05 Evolution of attitudes towards life extension.

09:25 Limits to extending lifespan.

11:33 Pros and cons of traditional science methods

14:25 Critiques of DeSci

15:44 Traditional institutions' views on DeSci

17:37 Contentious topics within your field

19:54 Religion influence on perspectives of aging

22:05 Life extension without limits

26:17 Recurring challenges in your career

29:31 Things you wish you knew earlier

30:51 Recommendations for young people

32:17 Why aging research is important for society.

35:12 Outro

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Lea Degen: https://twitter.com/lealeata

Keith Comito: https://twitter.com/KeithComito

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we had the privilege of having Michael Baran as our guest. Michael Baran, MBA, Ph.D. is Executive Director, WRDM, and partner at Pfizer Ventures. In this episode, Michael discusses the unique features of DeSci, highlighting how it is reshaping the scientific landscape and redefining traditional paradigms. We also explored the significant risks in early-stage science investment and discussed key factors deterring investors from entering the cryptocurrency and blockchain sectors. Michael draws insightful comparisons between DeSci and the Traditional model, exploring both their similarities and differences. Other topics we discussed are the underappreciated values of traditional biotech, common misconceptions about Biopharma, the need for maintaining scientific quality, and many more. Feel free to navigate any topics discussed in the Podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:07 What is the strong case for DeSci? 2:57 Advantages of DeSci Over Traditional Biotech 3:00 Risks associated with investing in early-stage science 4:35 DeSci vs. Traditional Model: Similarities and differences 7:38 Strongest critique of Desci 11:09 Measuring success 13:26 Underexplored areas in Biopharma 15:32 Common misconceptions about Biopharma 16:51 Pfizer partnership models 23:40 Underappreciated values of traditional Biotech 26:43 Maintaining scientific quality 28:40 Contentious topics within your field 31:14 Implicit knowledge in Biopharma 34:26 Recurring challenges in Michael's career 35:42 Selecting the best ideas 39:18 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to Special thanks to Lea Degen: https://twitter.com/lealeata Michael Baran: https://twitter.com/scienceman2023 ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Dr. Jocelynn Pearl, a biotech scientist and the co-founder of LabDAO, an online life science research community whose mission is to accelerate progress in the life sciences by making scientific tools more accessible.

In this episode, Jocelynn shares insights on the factors and events that birthed the idea of Decentralized Biotech and the importance of incentivizing knowledge sharing so it becomes accessible to other researchers.

We also discuss the pros and cons of centralization within the Biotech sector, the limits of online collaboration, and many more.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

___

⭐ Timestamps:

0:00 Intro

1:34 The decentralized biotech movement

4:03 Incentivizing knowledge sharing

06:38 What sparked your interest in decentralized science?

13:36 Downsides of centralization in the Biotech sector

16:29 Limits of online collaboration

18:46 Sharing tacit knowledge

20:32 New scientist entrepreneurs you have come across

23:16 Positive aspects of centralization.

26:22 Insights gained over the last few years

27:46 Implicit knowledge in Biotech

29:50 Ensuring funding for good projects

32:38 Contentious topics within LabDAO

34:33 Why Biotech companies prioritize experienced teams for funding

41:01 Outro

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Lea Degen: https://twitter.com/lealeata

Dr. Jocelynn Pearl: https://twitter.com/JocelynnPearl

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Juan Benet, the founder of Protocol Labs, an open-source research, development, and deployment laboratory.

In this episode, Juan shares the story of his journey, the origins of Protocol Labs, and how he got involved in building IPFS and Filecoin.

We uncover the underlying issues hindering technological advancements and dive deep into the translational science problem which Juan Benet believes is the biggest challenge facing science today. Juan emphasized the need to facilitate the translation of scientific discoveries and knowledge into real-world applications and solutions that can improve human health and benefit society at large.

Moving forward, we explore the impact of cryptocurrency on scientific research and its transformative potential. Other topics we discussed on the podcast include intersection of Artificial Intelligence and the future, risks associated with Advanced General Intelligence systems and how AGI could potentially shape the future of society.

Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below.

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⭐ Timestamps:

00:00 Intro

01:32 Background story of Juan Benet

09:28 Fundamental issues holding back technological advancements

14:36 Structural difference between the private sector and academia

21:17 Cryptocurrency's impact on scientific research

30:13 How Protocol Labs is structured

39:19 Protocol Labs' objectives and metrics measurement approach

44:59 Underexplored areas in scientific research

1:02:53 AI and the future

1:11:13 Risks associated with AGI systems

1:22:40 How AGI would shape the future society

1:41:24 What ideas are you most excited about?

1:51:48 Recommendations

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

Special thanks to

Vincent Weisser: https://twitter.com/vincentweisser

Juan Benet: https://twitter.com/juanbenet

____

Let's connect:

Website: https://bit.ly/3d6nh2C

X: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of The DeSci Podcast. Today, we're joined by Niklas Anzinger, the founder and GP of Infinita, the first VC fund based in a modern charter city (Prospera), investing in founders overcoming regulatory bottlenecks in bio-/healthtech, hardware & crypto-finance through network states & startup cities.

In this episode, Niklas shares insights on Infinitia Funds and how it supports innovative ventures and technological startups. Niklas also sheds light on Prospera's mission to create a self-sustaining and efficient business environment for entrepreneurs and innovative minds to thrive.

We further discuss how poor governance hinders human potential and causes economic stagnation. This highlights the pressing need for an alternative and improved regulatory system, which would revolutionize the startup landscape, fostering growth and progress. We also explored how Network States and Startup Cities can positively impact fields like Longevity and Science in general.

As the discussion progressed, we delved into other projects such as Zuzalu, which aims to build new cities and states with better regulatory systems to foster innovation in extending human lifespans and enhancing overall health outcomes.

Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below.

___

⭐ Timestamps:

0:00 Intro

0:58 About Niklas Anzinger

2:08 Infinitia VC Funds and its initiatives

5:24 Stranded Technologies Podcast

8:00 Infinitia’s areas of interest

14:36 The need for an alternative regulatory system

17:33 Competitive governance

28:42 How better regulatory structures would benefit Longevity and DeSci

47:58 Prospera and its mission

51:32 Sebastian’s thoughts on an ideal country to settle in

54:14 How to get involved

____

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to

Sebastian Brunemeier: https://twitter.com/sebastian_gero

Niklas Anzinger: https://twitter.com/NiklasAnzinger

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we were joined by Jesse Hudson, the Chief Legal Architect at Molecule, Chris Byrnes, an IP Legal Advisor also representing Molecule, and Benji Leibowitz, Product Manager at Molecule. The existing intellectual property (IP) system faces several challenges that hinder its effectiveness and innovation potential. Patent trolls, the system's lack of efficiency, and the high transaction costs associated with acquiring and enforcing IP rights further burden inventors, researchers, and scientific enterprises. In this episode, we explore the groundbreaking concept of IP Tokens and how they can help solve the issues plaguing the current IP system. We explain what IP Tokens are and how they differentiate from IP-NFTs. We also discuss how IP tokens could facilitate scientific entrepreneurship and how they open up decentralization in science by enabling a system where the community can partake in the governance processes. Navigate the various topics covered in the Podcast using the timestamps below. ____ ⭐ Timestamps: 0:00 Intro 2:11 About Jesse Hudson 2:54 About Chris Byrnes 5:47 Fundamental issues within the IP system 11:16 How Molecule facilitates Scientific entrepreneurship 20:12 Overview of Intellectual Property 32:09 What is an IP-NFT? 37:05 IP Tokens and why they matter. 51:11 Digitizing the process of IP licensing 1:02:41 IP Tokens and Decentralization 1:10:16 IP financing 1:16:31 Enforcing IP rights 1:22:22 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to Special thanks to: Benji Leibowitz: https://twitter.com/benjileibo Jesse Hudson: https://twitter.com/jsshdsn Chris Byrnes: https://twitter.com/reimagineIP ____ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! Today, we were joined by Ben Reinhardt, founder of Speculative Technologies, a nonprofit research organization that runs coordinated research programs to unlock groundbreaking innovations.

In this episode, we explore the qualities that make funders exceptional and the key factors that contribute to successful startup grants. We also shed light on the social and financial asymmetries between grantor and grantee, highlighting their negative impact on the funding process.

Other topics we discussed are the differences between small and large grants, limitations of grant-making programs, common misconceptions between the public and private sector and many more.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

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⭐ Timestamps:

0:00 Intro

1:46 Characteristics of good funders

6:39 Key factors for successful startup grants

13:02 Asymmetries in grantor-grantee relationships

16:20 Small and large grants

19:09 Coordination in research

26:50 Pros and cons of grants

30:28 Limitations and drawbacks of grant-making programs

36:10 Common misconceptions between the public and private sector

38:07 Contentious issues within your field

42:42 Reforming science funding

44:20 How do you approach research management?

46:52 Topics Ben wants to write about

52:04 Outro

____

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to:

Lea Degen (host): https://twitter.com/lealeata

Ben Reinhardt: https://twitter.com/Ben_Reinhardt

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! We are excited to have Nadia Asparouhova, an independent researcher and author of "Working in Public: The Making and Maintenance of Open Source Software", as our guest today.

In this thought-provoking episode, we delve into the world of early-stage science funding and philanthropy. We discuss the role philanthropy plays in society and how it has evolved over the years. We also explore new funding mechanisms that have emerged to revolutionize the landscape of early-stage science, as well as the limitations and setbacks associated with these new funding mechanisms.

Additionally, we discuss the political challenges of early-stage science funding and the pivotal role that government and individual patrons should play in supporting early-stage science.

Please refer to the timestamps below to navigate through any of the topics discussed in the podcast.

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⭐ Timestamps:

00:00 Intro

01:40 The role of philanthropy.

03:16 What drove your interest in science funding?

05:00 The uniqueness of tech

06:19 Understanding early stage science

08:27 New funding mechanisms for early stage science

13:02 Limitations to the new funding mechanisms

16:09 Importance of peer review

18:25 Common misconceptions about early stage science funding

21:47 Evolution of philanthropy

27:18 Philanthropy and the government

29:35 Political Challenges of early-stage science Funding

35:25 Legitimacy in early stage science funding

41:47 Science philanthropy: Then & Now

47:23 Outro

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to:

Lea Degen (host): https://twitter.com/lealeata

Nadia: https://twitter.com/nayafia

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. Today, we had the privilege of having Dr. Martin-Immanuel Bittner as our guest. He is the CEO of Arctoris, which is the world's first fully automated platform for drug discovery, focused on accelerating the drug discovery process.

In this episode, we explore a variety of fascinating topics related to drug discovery. Dr. Bittner shares insights on the story behind building Arctoris and its mission to accelerate the drug discovery process. We also talk about how the drug development process has evolved over the years and the need to automate drug discovery research.

Other topics discussed were challenges stemming from the lack of rigorous funding in biotech, common misconceptions about automation, and many more.

Please feel free to navigate through any of the topics discussed in the podcast using the timestamps below.

____

⭐ Timestamps:

0:38 Intro

1:18 About Arctoris

2:52 What drove your interests in building Arctoris

4:23 Learnings from running Arctoris

5:53 What area needs more focus

8:03 Common misconceptions about automation

10:01 Flexibility in automation

13:44 Underexploited areas

16:09 Antibiotic resistance problem

17:58 Funding structures for Biotech companies

20:15 Investing in Biotech

22:38 The private sector and Academia

25:00 Changing beliefs on the need of automation in drug discovery

27:08 Contentious issues within your field

29:06 Implicit knowledge in drug discovery

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to:

Lea Degen (host): https://twitter.com/lealeata

Martin: https://www.linkedin.com/in/martinimmanuelbittner/?originalSubdomain=uk

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! Today, we had the privilege of having Martin Karlsson as our special guest. Martin is the CEO of Lateral, an innovative web app designed for scientists, enabling them to read, find, share, and organize their research seamlessly in a single platform for enhanced efficiency.

In this episode, we delve into a wide range of intriguing topics. Martin shares insights on Lateral's AI tools and the best way to effectively utilize these tools. We also dive into the future of research, gaining profound insights into the untapped potential within the field.

We then explored the cutting-edge capabilities of AI, the importance of retaining human agency in the research process, and the need to ensure the transfer of knowledge across generations.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

____

⭐ Timestamps:

0:48 Intro

1:26 About Lateral

2:35 Best way to utilize Lateral AI tools

3:40 Key takeaways from building Lateral

06:09 What drove your interest in DeSci

07:47 The Future of Research

11:03 Underexploited areas in DeSci

12:50 Managing differing opinions in DeSci

14:22 Limits of outsourcing research

16:00 Retaining human agency in the research process

20:36 What key areas would you develop if Lateral secured more funding?

21:53 Challenges of running Lateral

25:05 What are you skeptical about?

26:28 Valuable tacit knowledge about Desci

30:55 Learnings from past experiences

____

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to:

Lea Degen (host): https://twitter.com/lealeata

Martin: https://twitter.com/jmartink

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast! In this one, we were joined by Niklas Rindtorff, a physician-scientist and co-founder of LabDAO, an online community of life scientists collaborating to make life scientific tools more accessible.

In this episode, Niklas shares insights about the benefits of conducting life science research online, how scientific research has evolved over the years and the importance of collaboration within the scientific community.

Going further, we delve into the complex topic of ownership rights within decentralized autonomous organizations (DAOs) and how LabDAO navigates this space.

We also highlight some underappreciated aspects of academia and compare the dynamics of building in the private and public sectors as well as common misconceptions about these sectors. Niklas also shares some valuable knowledge about Decentralized Science, drawing from his own personal experiences and expertise.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

____

⭐ Timestamps:

0:54 Intro

1:33 About LabDAO

3:32 Why do life science research online?

06:42 Ownership rights within DAOs

12:11 Valuable insights you wish you had before starting LabDAO

13:19 How have these new insights shaped LabDAO's structure?

15:18 Overlooked areas in Decentralized Science

16:43 Differences in the private and public sector

18:48 Building in the public sector vs private sector

23:23 Underappreciated aspects of Academia

26:20 Conflicting viewpoints on LabDAO’s operational strategies

31:46 Valuable tacit knowledge about DeSci.

36:18 What key areas would you build on if LabDAO secured more funding?

37:10 Misconceptions about Web 3

39:28 Overlooked areas in Decentralized Science

40:37 What we are building at LabDAO and how to get involved

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to:

Lea Degen (host): https://twitter.com/lealeata

Niklas: https://twitter.com/Niklas_TR

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, we were joined by Dr. Emil Kendziorra and Kai Micah Mills, co-initiators of CryoDAO, a decentralized community dedicated to advancing cryopreservation research.

In this podcast, we discuss the field of cryonics, including its origins and how it has evolved over the years. Dr. Emil and Mills also explain how cryopreservation works, the underexploited areas in the field of Cryonics, and how it should be Improved.

We also address some of the common misconceptions about cryopreservation and recommended resources for those interested in learning more about Cryonics.

Finally, our guests share their thoughts on what the future of cryonics might hold and discuss some of the most contentious topics in the field.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

____

⭐ Timestamps:

0:00 Intro

1:07 Brief overview of the field of Cryonics

3:45 Origin and Evolution of Cryonics

5:51 How does Cryopreservation work?

7:00 What drove your interest in Cryonics?

10:13 Underexploited areas in Cryonics.

11:36 What is the strongest argument against Cryonics?

13:35 How public perception of Cryonics has developed over the years.

16:29 Why pets instead of humans?

18:08 Why did you become a DAO?

22:43 Areas of overlap in cryonics.

25:32 The future of Cryonics.

28:37 What is the most contentious topic in Cryonics?

30:44 Common misconceptions about cryopreservation

33:27 Resources for people interested in the field of Cryonics.

35:39 How to get involved.

____

Special thanks to:

Lea Degen (host): https://twitter.com/lealeata

Kai Micah Mills: https://twitter.com/kaimicahmills

Dr. Emil Kendziorra: https://www.linkedin.com/in/emilkendziorra/

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this one, we had the pleasure of talking with Laura Minquini, who is leading AthenaDAO, a community-led movement that is improving female reproductive health through the identification, financing, and support of research projects that are working on its potential cures. We talked about Laura's story, the global panorama of the problem that she is solving, and the journey and projections of the organization that she founded and bio.xyz helped shape.

Navigate through the topics discussed in this podcast using the timestamps below.

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⭐ Timestamps:

0:55 Intro

1:50 About Laura Minquini

8:36 About AthenaDAO

11:21 Research in Female Reproductive Health Overview

15:49 AthenaDAO structure and projects in its pipeline

23:26 AthenaDAO's first IP-NFT

26:10 Aging & Fertility

33:41 Why scientists choose to join AthenaDAO

39:44 Bio.xyz acceleration journey

43:23 Strategies to raise awareness

47:35 How to Contribute to AthenaDAO

51:34 What would happen if AthenaDAO succeeds

54:18 Outro

____

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to:

Aastha (host): https://twitter.com/aasthajs

Laura Minquini: https://twitter.com/LauraMinquini

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, we were joined by ValleyDAO's Co-founder, Albert Anis, and Communications Lead, Morgan Richards.

In this video, Albert Anis and Morgan Richards provide a deep dive into the interesting field of Synthetic Biology, and the significant role that ValleyDAO plays in driving innovation in this area.

We also explored the traditional funding model for Synthetic Biology and the difficulties it presents for researchers. They then emphasize the need for a new, decentralized approach to funding and the importance of collaboration in the research field.

Albert and Morgan also go on to discuss the challenges of building in DeSci, and ValleyDAO's unique approach to incubating new projects, which involves providing funding, expertise, and a supportive community for researchers.

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below.

____

⭐ Timestamps:

0:40 Intro

1:18 Albert Anis’ Background

6:26 What drove your interest in Synthetic Biology?

11:19 About Valley DAO

15:33 What is Synthetic Biology?

19:58 The problem of the traditional model of funding Synthetic Biology.

24:42 What areas are ValleyDAO focused on?

31:26 ValleyDAO’s process of incubating other projects

36:23 Value of Web 3 tools to Synthetic Bio Researchers

41:20 Challenges of building in DeSci

45:50 Areas of Overlap in ValleyDAO

47:40 ValleyDAO upcoming projects

50:14 How to get involved

50:41 Outro

____

Special thanks to:

Alex LaBossiere (Host): https://twitter.com/adlabossiere

Albert Anis: https://twitter.com/thealbertanis

Morgan Richards: https://twitter.com/Mxltiplex

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, we had the pleasure of talking with Andrew Verbinnen and Andrew Bakst from HairDAO, the second BioDAO ever to mint an IP-NFT. Their mission is to turn hair loss into a problem of the past by funding assets that they believe will accelerate its cure. Throughout the conversation, we delve into a variety of fascinating topics related to hair loss.

We explore the bigger picture of this issue and highlight the crucial role of DeSci in expediting the discovery of solutions. And our guests also provide valuable insights gained from their experience in building in this ecosystem, shining a light on the HairDAO community, as well as the exciting projects that they have funded and upcoming initiatives.

Navigate through the topics discussed in this podcast using the timestamps below.

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⭐ Timestamps:

0:23 Intro

01:08 About Andrew Verbinnen

03:01 About Andrew Bakst

04:11 Why HairDAO

05:50 Hair Loss Research & Solutions State

10:17 Hair Loss Multiphase Problem

11:57 HairDAO Community

15:05 HairDAO’s First IP-NFT

16:53 Study of Prof. Ralf Paus

19:41 Crypto & Global Cooperation

20:37 First Patient Database in DeSci

22:43 Importance of IP-NFTs

25:02 Learnings from Building a BioDAO

27:01 HairDAO Vision

27:58 HairDAO Upcoming Initatives

31:11 Outro

____

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to

Special thanks to:

Alex LaBossiere (Host): https://twitter.com/adlabossiere

Andrew Verbinnen: https://twitter.com/VerbinnenAndrew

Andrew Bakst: https://twitter.com/andrew_bakst

____

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.com/invite/moleculedao

Welcome to this episode of the DeSci Podcast, where we dive deep into the technology behind IP-NFTs and explore the possibilities of decentralized data storage. 

In this episode, Stefan Adolf, a senior web3 engineer at Molecule, and Benji Leibowitz, a former biotech venture capitalist and now a product manager at Molecule, discuss the modularity of IP-NFTs, the advantages of ERC721, 1155, and 3525 token standards.

We also discuss the benefits of Arweave and IPFS for metadata and storage, Lit Protocol and unlocking data, custodial wallets and MPC providers, the SDK for developers, and the possibilities of permissionless minting and open source strategies with v2 and v3 of the IP-NFT.

We hope you can learn a lot about the amazing possibilities of the decentralized tech stack and how you can build with IP-NFTs with this episode and feel free to use the timestamps below to navigate through the episode. 

Navigate through the topics discussed in this podcast using the timestamps below.

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Timestamps:

00:00 - 01:42 Intro
01:42 - 04:30 What is the IP-NFT and who should use it?
04:30 - 08:40 Token Advantages (ERC721, 1155, and 3525)
08:40 - 11:18 IP-NFT V2 (Mint-passes and Reservations)
11:18 - 12:40 Who is the ideal user for a min-pass?
12:40 - 17:24 Where is the metadata of an IP-NFT stored, and how is it structured?
17:24 - 25:19 Difference between web3 and web2 storage
25:19 - 29:21 Content gating with DAO tools
29:21 - 34:56 The role of Lit-Protocol within the IP-NFT
34:56 - 49:00 Frontend of the IP-NFTs and on web3 wallets
49:00 - 51:59 When can people start building on this technology (wen SDK?)
51:59 Outro

____

If you want to watch the Podcast on YouTube, you can find all the important links below. And if you want to join us on the show as a speaker or have guest ideas; please mail us at podcast@molecule.to
linktr.ee/thedescipodcast

Special thanks to: 

Heinrich Tessendorf (Host): https://twitter.com/Heintess_GM
Stefan Adolf: https://twitter.com/stadolf
Benji Leibowitz: https://twitter.com/benjileibo

____

Let's connect:
Website: https://molecule.to/
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, Vera Gorbunova, endowed Professor of Biology at the University of Rochester, co-director of the Rochester Aging Research Center, and co-founder of the new journal Aging Biology, run by scientists for scientists, shares with us a bit of her vast knowledge in the field of Longevity. She talked about the problems of the current scientific system, the partnership that her laboratory made with VitaDAO, and about the research that she is currently carrying out.  

Navigate through the topics discussed in this podcast using the timestamps below.

 ____ 

Timestamps: 

0:42 Intro
2:53 Vera's Life Story & Background
7:44 Comparative Longevity Approach
14:12 Serendipitous Discoveries
15:34 DNA Repairing Fidelity & Epigenetics Reprogramming
24:46 Who are the heroes of Vera
27:09 What Vera strongly believes and that other people disagree
32:28 Possible Nobel Prize-winning work
35:14 Chromatin: Hallmark of Aging
39:25 HSC Stem Cells  
45:20 Extracellular Matrix
50:12 VitaDAO x Vera’s Lab Partnership on Naked Mole Rats
1:00:26 Programmed vs Damage Theory of Aging
1:11:07 Issues between Scientific Journal Publishers, Editors and Reviewers
1:17:42 Potential of Decentralized Scientific Journals & Peer-review
1:32:18 Final Conclusions  

____  

Special thanks to:  

Sebastian Brunemeier (Host): https://twitter.com/sebastian_gero  
Vera: https://www.linkedin.com/in/vera-gorbunova-64a97b46/  

____  

Let's connect:  

Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, Michael Gibson, co-founder and general partner of the 1517 fund, author of the new book ‘Paper Belt on Fire: How Renegade Investors Sparked a Revolt Against the University’ and one of the key people involved in launching the Thiel Fellowship in 2010 (where he helped Vitalik Buterin shape Ethereum), tells us about his vision of legacy institutions and how we can modernize them to encourage great global innovations once again.  

You can already get his excellent book, discussed in the episode, on Amazon: https://www.amazon.com/Paper-Belt-Fire-Fight-Progress-ebook/dp/B099FZR4C3 

Navigate through the topics discussed in this podcast using the timestamps below.

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⭐ Timestamps: 

0:00 Intro
4:03 Book: ‘Paper Belt on Fire’
9:26 Michael’s Background
14:20 Innovation in America is slowing down
19:20 Why Michael drop out the Academia
24:08 ‘If the college degree were a drug they would not be passed by the FDA’
29:07 Cloud Universities
30:23 How to rebuild the Scientific Structure
38:59 VitaDAO and Alternative Funds
40:39 Accredited Investors
42:33 Investment Issues
44:26 Public Companies
46:00 New Disclosure Standard
49:03 Reproducibility Issues
53:42 Decentralized Science
1:07:00 How to motivate the next generation of great scientists  

____ 

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to 

Special thanks to:  

Sebastian Brunemeier (Host): https://twitter.com/sebastian_gero  
Michael: https://twitter.com/William_Blake  

____  

Let's connect:  

Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao

Today we have a special one! In this episode, we have Vitalik Buterin as a guest, interviewed by Vincent Weisser. 

They discuss the intersection of science and cryptocurrency, focusing on the concept of "decentralized science."  Vitalik explains how decentralized technologies, such as cryptocurrency, can improve science and the institutions of science by allowing for more diverse funding and collaboration among people.

He also mentions specific tools, such as quadratic funding and decentralized autonomous organizations (DAOs), that can be used to fund and structure scientific projects.   He also highlights his current project, "Balvi", which is focused on addressing the COVID-19 situation and is funded by cryptocurrency.
He also mentions the challenges of scaling up quickly and how this can be a good approach for established donors and talks about the use of technology such as DeSci and reputation systems to help solve the problem of determining who is trustworthy.   

There is undoubtedly much more to be found in this episode and we hope you enjoy this conversation between Vitalik Buterin and Vincent Weisser. Make sure to skip between the timestamps below to find your favorite topics and learn more about the discussed topics through all the linked resources below.

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Some of the resources discussed. 

- Vitaliks blog: https://vitalik.ca/
- Vitaliks twitter: https://twitter.com/vitalikButerin
- Decentralized Science Explainer https://ethereum.org/en/desci/
- Ending Aging book: https://en.wikipedia.org/wiki/Ending_Aging- Science DAOs like: http://vitadao.com/
- Some of the projects he supported https://cryptorelief.in/, https://impetusgrants.org/, https://www.sens.org/, https://arcinstitute.org/
- Balvi (Pandemic Prevention): https://twitter.com/VitalikButerin/status/1522017142320685057
- Quadratic Payments by Vitalik: https://vitalik.ca/general/2019/12/07/quadratic.html
- DeSoc Paper by Puja, Glen and Vitalik: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4105763
- Progress: https://www.theatlantic.com/science/archive/2019/07/we-need-new-science-progress/594946/
- Network States: https://vitalik.ca/general/2022/07/13/networkstates.html
- RadicalxChange: https://www.radicalxchange.org/
- The most important century https://www.cold-takes.com/most-important-century/
- Curveballs: pandemics, existential, risks from nuclear, ai, bio, wars
- Recommend reading: https://80000hours.org/
- DeSoc x DeSci by Puja: https://www.youtube.com/watch?v=MUzwSPmP4nY

____  

Timestamps:  

00:00 - 00:37 Intro
00:37 - 06:36 Vitalik's definition of DeSci and what he is most excited about.  
06:36 - 09:32 Improvements to retroactive or quadratic funding.
09:32 - 11:30 Vitalik on DeSoc in the context of science (Decentralized Society).  
11:30 - 12:51 What to build at the intersection of DeSci and DeSoc?  
12:51 - 13:46 Which areas of Science is Vitalik most excited about?
13:46 - 17:17 How the Shiba Inu tokens actually funded Covid research.
17:17 - 22:40 Why crypto is such an excellent funding method.
22:40 - 31:00 Which learnings did he incorporate into other projects like "Balvi"?
31:00 - 38:33 What's holding back scientific progress, and what is he most excited about?  
38:33 - 44:37 The most important century ever? Vitalik on AI progress, Singularity, and existential risks.  
44:37 - 46:47 What to build in the DeSci space?
46:47 - Vitalik's content recommendations in the science space.

___  

Let's connect:  

Website: https://bit.ly/3d6nh2CTwitter:
https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao

Welcome to another episode of the DeSci Podcast. In this episode, Stanley Bishop, AKA Science Stanley, data scientist and head of data science at LabDAO talks about AI, what it means to be a data scientist and how it intersects with decentralized approaches. We also talk about how this can be applied across individual health, collective health, the planets, genome sequencing and language models and what this could mean for the future of the organization and the future of work.  

Stanley Bishop also talks about LabDAO’s collaboration with "Research to the People" in order to build an integrated and traditional data marketplace where treatments can be shared between physicians so they can compare notes and figure out the best clinical path for their patients which can be impactful for patients that might have rare or complex conditions, New Atlantis DAO and its mission to provide a solution for climate change and many more.  

Navigate through the topics discussed in this podcast using the timestamps below.

 ____  

Timestamps:  

0:00 Intro
1:38 What is a data scientist?
3:09 How has that led you to Lab DAO?
04:51 What does being a data scientist within a DeSci organization look like?
06:15 What projects are LabDAO working on right now?
09:18 LabDAO overall structure.
11:56 LabDAO's partnership with Research to the people.
16:17 The future of translational research.
18:36 What else is possible with DeSci?
23:42 New Atlantis DAO.
31:07 Recommendations for scientists transitioning into Web 3.
34:09 Collaboration with TalentDAO.
42:13 Other use cases of TalentDAO.
46:16 What AI trend do you expect to gain traction in the future?
50:39 Remunerating contributors. 

____ 

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to  

Special thanks to:  

Erin Magennis (Host): https://twitter.com/erinmagennis
Stanley:https://twitter.com/ScienceStanley

____  

Let's connect:  

Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao

Welcome to episode Nr. 7 of the DeSci Podcast! In this episode, Tyler Golato, Co-founder and CSO of Molecule DAO joins us as we discuss the problems of scientific research and funding and necessary changes that need to be made in the way funding is done.  
We talk about the impact of decentralization in research, the requirements for allocating funds for research, and the future of Molecule and Bio-DAOs in general.  Tyler also shares his background in biochemistry, molecular biology, and oncology research, and how his experiences led him to Molecule.
We hope you enjoy this episode and you can go through any of the topics discussed in the Podcast using the timestamps below. 

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Timestamps:   

0:40 Background story of Tyler Golato.
01:16 What drove your interest in healthcare?
12:45 What is the argument that research can be carried out in a decentralized manner and why does it matter?
18:17 What is the level of domain expertise needed to allocate funds for high-quality research? 21:20 What problems of scientific research and funding do you think requires decentralization to solve?
25:52 What is your vision for the future of Molecule and Bio-DAOs?
31:24 What other changes do you think need to be made in the way funding works?
34:52 What do you think about incentives in DeSci?
40:16 How would you approach the problem of waiting governance?
45:03 How do you determine success and measure outcomes?
47:20 What would you say is the bull case and bear case for DeSci?
51:05 How to get involved.
52:17 Outro 

____ 

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to  

Special thanks to:  
Alex LaBossiere (Host): https://twitter.com/adlabossiere
(Check Alex his own podcast here: https://open.spotify.com/show/7lf0G6SBTArFlJYuHlPPoy?si=adcfa5f7a82d4708)
Patrick Malone: https://twitter.com/GolatoTyler

____  

Let's connect:  

Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao 

Molecule - The future of medicine belongs to everyone

Welcome to episode Nr. 6 of "The DeSci Podcast"! In this episode, Patrick Malone, a physician-scientist turned investor at KDT Ventures where he invests in early-stage life science and healthcare, tells us about what drove his interest in investing in healthcare, what Tech-Bio is, and how it relates to the traditional understanding of Biotech. 

He also explains, why machine learning is effective in drug discovery, the biggest problem facing scientific research and funding models today, the future of scientific research, and much more. Patrick Malone argued that rewarding negative findings which help to discover what doesn’t work or what isn’t true in a previous research publication will greatly reduce the problem of reproducibility.   

Feel free to navigate through any of the topics discussed in the Podcast using the timestamps below. 

____  

Timestamps:  

0:00 Intro
0:44 Background story of Patrick Malone
1:25 What drove your earlier interests in Academia?
5:53 Why was Investing of major interest to you?
8:36 What is TechBio and how does it compare to the traditional understanding of Biotech?
13:19 How can TechBio deliver up to the expectations of people towards it?
18:13 Which other fields can the principles of TechBio be applied to?
21:54 Why is there a lesser ROI in TechBio and Biotech compared to other technologies?
25:24 What drives you to write?
27:34 How was your experience with working with both Academia and Ventures?
30:04 What is the biggest problem facing scientific research and funding models today?
32:25 How would not having to apply for grants change the research focus of scientists?
34:25 What is your take on making research open source?
37:27 How can these new developments come into actualization?
39:52 What happens when scientific discoveries are no longer understandable by humans?
43:28 What do you think more people should be paying attention to?
46:11 Ending and outro.  

____  

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to  

Special thanks to:   

Alex LaBossiere (Host): https://twitter.com/adlabossiere
(Check Alex his own podcast here: https://open.spotify.com/show/7lf0G6SBTArFlJYuHlPPoy?si=adcfa5f7a82d4708)
Patrick Malone: https://twitter.com/patricksmalone

____  

Let's connect:  

Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao 

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 5 of the DeSci Podcast! In this Episode, Allison Duettmann, President and CEO of Foresight Institute tells us how she got into futurism, why people are so pessimistic about the future, how Foresight chose the most important things to work on, Allison's positive visions of the future for humanity, what are Tech Trees and more! We hope you enjoy!  

____  

Timestamps: 

0:00 - Nanobots & Cryonics
0:27 - Allison & Foresight Intro
1:29 - How Allison got into futurism
4:36 - Positive visions of the future for humanity and raising reality to meet your expectations
8:16 - Optimism 11:52 - Why people are so pessimistic about the future
16:58 - Areas where people are too optimistic
19:12 - Foresight - how they found the most important things to work on (referring to decentralized computing, molecular machines, biotech for health extension, neurotech and space tech)
20:30 - Decentralized Computing
22:00 - Biotechnology for rejuvenation, longevity & cryonics
22:58 - Molecular and Nanotechnology
24:18 - Neurotechnology
26:01 - Spacetech
26:42 - What are Tech Trees?
32:27 - Surprising/Technological Bottlenecks
34:38 - Areas of Overlap between Tech Trees
38:40 - The unlock that DeSci Provides for Allison's work at Foresight
43:24 - Vetting people for domain expertise to participate in DeSci
46:52 - The Longevity Prize
50:00 - What excites Allison the most in DeSci and the technologies Foresight covers  
52:55 - How to get involved at Foresight 

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Links mentioned:  

Balaji on Tech Trees: https://twitter.com/balajis/status/1456163613857570821?s=20&t=XP1sJ8gBEKNw-V7fPHsNpw
Starships & Tokens (The Map) by Trent McConaghy https://medium.com/@trentmc0/starships-and-tokens-d8c32728a24b
Aaron King: Longevity Tech Tree: https://www.youtube.com/watch?v=yg9Jpk2dLQM&t=164s 

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Notable quotes from Allison: 

"I got interested in Technologies through a wish for a longer happier life for myself and for civilization."  

"Despite the fact that life has been improving pretty steadily over the last hundreds of thousands of years, our realization that it has been has not been steadily adjusting. Most of the time if you ask around people think that things are getting worse, that violence is increasing, and pretty substantial societal flaws are increasing and so I think it doesn't often match with the actual improvement in living conditions that many of us were fortunate enough to receive over the past few hundred thousand years."   

"A positive outlook I think starts with a gratitude for how far we've come and just realizing what our ancestors put forth and how much they paid forward for us to get to where we are."  

"Rather than having this more default vision on the future of what would the path be in which we all self-destruct (which is certainly a morbid fantasy) which is easier to think about and somehow weirdly more attractive to our human minds actually, rather asking the other question of what would it mean to actively put a foundation in place in which we could build wonderful worlds."  

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If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to  

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Let's connect:  

Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao 

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 4 of the DeSci Podcast - Today we're exploring the decentralized science space together with Jack Scannell! Jack coined the term Eroom's Law, which notes that the cost of new drug approvals is rising exponentially, in contrast to Moore's law, which notes that the number of transistors on a microchip doubles about every two years, though the cost of computers is halved.  

In this podcast, Jack talks about how we can do better drug discovery, specifically, the tools and frameworks we can use to choose the right drug discovery model and feed that into investment decisions. His new paper in Nature Reviews Drug Discovery addresses exactly that: https://rdcu.be/cWTtO 

In this podcast, Jack argues that quality beats quantity when it comes to assays, but actually the best thing is quality AND quantity. So it's better to test a small number of therapeutic candidates in a really good model than it is to test a very large number of computer candidates selected from the same universe in a model of low validity - the best example of this is in antimicrobials discovered around 1930 by Gerhard Domagk. Jacks says that the model validity used in Germany in the 1930's is better than the model validity used in the early 90's.  

The technological barrier in drug R&D has shifted from chemistry to effectively the tools that tell you whether or not that chemistry is useful. It's not that we can't make compounds, we probably can in many cases make those compounds but what we can't do is we can't distinguish the ones that do something useful from the ones that don't. It's not that we can't identify targets, we can, but we can't tell the good ones from the bad ones - so the critical resource in drug R&D is probably the models, which Jack's paper calls "decision tools" that let you sift the good stuff from the bad stuff.   

Jack on what interested him about VitaDAO and Molecule: You create value not by making current markets a little bit more efficient, you create value by making markets exist where none existed before. Outside of a few well-ventured universities, universities are terribly under-ventured and also the people at those universities don't have the right tools to present their material in such a way that it could be ventured so it struck him that providing a low transaction cost, standardized platform to make an eBay for IP might be an extremely valuable thing to do because you could create markets where none existed before.

Important links mentioned in the episode:
The new Nature Reviews Drug Discovery paper.
“Predictive validity in drug discovery: what it is, why it matters, and how to improve it”: https://rdcu.be/cWTtOThe
Emulate (organ chip) pre-print: “Qualifying a human Liver-Chip for predictive toxicology”:  https://www.biorxiv.org/content/10.1101/2021.12.14.472674v4

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A huge thanks again to Sebastian and Jack for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to  

You'll also find all links to YouTube, Discord, Twitter and our website via the following link - https://linktr.ee/thedescipodcast

_____  

Special thanks to:   
Sebastian Brunemeier (Host): https://twitter.com/sebastian_gero
Jack Scannell: https://twitter.com/JackScannell13

______  

Let's connect:  
Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao 

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 3 of the DeSci Podcast - Today we're exploring the decentralized science space together with our CEO of Molecule and Vincent Weisser, our Chief Ecosystem Officer!  

We're incredibly proud to finally speak in depth about our new project bio.xyz - Next to that, we are also digging into a lot of other interesting decentralized science topics. You can find all of them below, so you can skip around to find your favorite ones!   

Topics & Timestamps:  

00:00 - Intro  
01:31 - Background Story of Paul  
09:27 - Background Story of Vincent
13:43 - Why DeSci makes sense? (Valley of Death)
18:09 - How can BioDAOs solve current bottlenecks in science?  
21:29 - How does a BioDAO work internally and what part plays Molecule here?  
31:41 - What is bio.xyz and how does it relate to Molecule?  
35:10 - bio.xyz cohort; PsyDAO  
39:48 - bio.xyz cohort; AthenaDAO
42:30 - bio.xyz cohort; ValleyDAO
46:05 - bio.xyz cohort; HairDAO
50:00 - Structure of bio.xyz  
51:13 - How can one apply for bio.xyz and advice for people who are interested to join
54:52 - How does the future of BiotechDAOs look like? (Vincent)
57:50 - How does the future of BiotechDAOs look like? (Paul)
01:02:52 - Ending & Outro 

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A huge thanks again to Vincent & Paul for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  Feel free to skip around the timestamps to find your favorite topics and thanks again for tuning in!
If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to  

You'll also find all links to YouTube, Discord, Twitter and our website on linktree here - https://linktr.ee/thedescipodcast

_____  

Special thanks to:   

Alex LaBossiere (Host): https://twitter.com/adlabossiere
(Check Alex his own podcast here: https://open.spotify.com/show/7lf0G6SBTArFlJYuHlPPoy?si=adcfa5f7a82d4708)
Vincent Weisser (Chief Ecosystem Development Officer of Molecule): https://twitter.com/vincentweisser
Paul Kohlhaas (CEO Molecule): https://twitter.com/paulkhls  

Find out more about bio.xyz here:  

Website: https://www.bio.xyz/
Twitter: https://twitter.com/bio_xyz
Discord: https://discord.gg/6ZeDSjhM2g

______  

Let's connect:  
Website: https://bit.ly/3d6nh2C
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao  

Molecule - The future of medicine belongs to everyone

Welcome to Episode Nr. 2 of the DeSci Podcast - Today we're exploring the decentralized science reformation together with no other than Balaji Srinivasan! We're incredibly proud to be joined by such a smart and well-known mind as a second guest on "The DeSci Podcast" show!    

Topics of this episode:  
→ Key factors holding back scientific progress and how to change it (also via DeSci). 🧪
→ What role does AI play here?
→ The future of human optimalism.
→ How to make predictions in technology?
(+ many more & some great advice for DeSci builders at the end from Balaji)  

Due to his nature, we're slipping in many other interesting topics while tackling those above! 💙  
A huge thanks again to Balaji for taking the time and for the valuable input - We hope you all can take something away from this episode on your DeSci journey.  

Feel free to skip around the timestamps to find your favorite topics and thanks again for tuning in! Also, if you prefer listening to podcasts on audio apps, feel free to search for "How To DeSci" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps and the show-notes below.   

If you want to join us on the show as a speaker or have guest ideas, please shoot us a mail at podcast@molecule.to  
You'll also find all links to Spotify, Discord, Twitter and our website via the link below - https://linktr.ee/thedescipodcast

_____  

Special thanks to:   
Alex LaBossiere (Host): https://twitter.com/adlabossiere
Vincent Weisser (Chief Ecosystem Development Officer of Molecule): https://twitter.com/vincentweisser
Balaji Srinivasan: https://twitter.com/balajis
https://balajis.com/
https://balajis.com/the-purpose-of-technology/
https://thenetworkstate.com/

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Timestamps:  
00:00 - Intro  
01:30 - Introduction of Balaji & The Network State
06:45 - Key factors holding back scientific progress
14:17 - How to change the research & funding structure
21:00 - Commonalities between New York Times and the nature of the Scientific Journals
38:00 - How does scientific progress unfold?
44:50 - Can AI be a dominant driver here?
49:10 - How to make predictions in technology
54:40 - The cyclical approach of history  
01:02:48 - Advice for builders in the DeSci space
01:04:29 - Last words, book advice & outro  

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Show-notes of the episode:   
https://twitter.com/balajis https://balajis.com/
https://balajis.com/the-purpose-of-technology/ https://thenetworkstate.com/
https://nexus.od.nih.gov/all/2021/11/18/long-term-trends-in-the-age-of-principal-investigators-supported-for-the-first-time-on-nih-r01-awards/ https://newscience.org/nih/
https://twitter.com/patrickc/status/1544067890403389441
https://project-evidence.github.io/ https://www.quantamagazine.org/in-new-math-proofs-artificial-intelligence-plays-to-win-20220307/ https://github.com/camoverride/lit/blob/master/The-Princeton-Companion-to-Mathematics.pdf

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Let's connect:  
Website: https://bit.ly/3BXtFUn
Twitter: https://twitter.com/Molecule_dao
Discord: https://discord.com/invite/moleculedao

Molecule - The future of medicine belongs to everyone