SPOTL]i[GHT - Nanion Technologies
By Nanion Technologies
Topics covering electrophysiology, ion channels and drug discovery.
SPOTL]i[GHT - Nanion Technologies Apr 13, 2021
Henzler-Wildman Lab (Katherine Henzler-Wildman & Nathan E. Thomas)
Katherine Henzler-Wildman (University of Wisconsin-Madison) & Nathan E. Thomas (University of California San Diego)
On this episode of the podcast we spoke with Katherine and Nathan about their most recent publication (measuring transport stoichiometry), you can read the full publication A solid-supported membrane electrophysiology assay for efficient characterization of ion-coupled transport here.
Nathan and Katie highlight the importance of staying persistent in science and following where the science takes you.
Keep updated with their latest research Katherine Henzler-Wildman Lab and Google Scholar[Katherine Henzler-Wildman],Google Scholar [Nathan E. Thomas]
Carlos Pardo-Pastor (King's College London)
Dr Carlos Pardo-Pastor (King's College London) is a Research Fellow in the Randall Centre for Cell & Molecular Biophysics. He started his scientific journey studying Human Biology, an MSc in Biomedical Research and then completed his PhD in Biomedicine at Universitat Pompeu Fabra.
On this episode of the podcast we spoke with Carlos about his most recent publication (Piezo2 Channel), you can read the full publication here. He highlights the importance of funding in science, his personal experiences in applying for grants, and some helpful tips for staying motivated as a researcher and connecting with peers in the field.
Keep updated with his latest research on ResearchGate and Google Scholar.
Shashank Pant (University Of Illinois Urbana-Champaign)
On this episode of the podcast we spoke with Shashank Pant( University of Illinois, Urbana-Champaign). We talked about how he started his journey as a researcher and how his curiosity of the scientific process continues to serve as a motivation to publish in high impact journals such as Nature (where he was recently part of an internationally collaboration with Renae Ryan's Lab (University of Sydney).
Here they looked at Glutamate, specifically providing insight into the mechanism by which glutamate transporters support their dual function, you can read the full publication here.
Connect with Shashank on LinkedIn. See the updates on his latest research on Google Scholar and ResearchGate.
Dr. Filip Van Petegem (University of British Columbia)
On this episode of the podcast we spoke with Dr. Filip Van Petegem about his journey starting as a structural biologist, with the work his lab is currently doing with regards to studying the structure and function of ion channels, membrane protein responsible for electrical signaling in excitable cells. His current projects involve voltage-gated sodium and calcium channels, as well as Ryanodine Receptors which he recently published a paper about, read it here.
Connect with Filip on LinkedIn. See the updates on his latest research on Google Scholar and ResearchGate and follow direct updates from his lab.
Dr. Yohei Ohashi (Medical Research Council (UK))
On this episode of the podcast we spoke with Dr. Yohei Ohashi about his unique journey from the University of Kyoto where he was working on his PhD specifically within plant molecular biology.
Connect with Yohei on LinkedIn. See the updates on his latest research on Google Scholar and ResearchGate.
Fernanda C. Cardoso, Ph.D (University of Queensland) - The Significance of Drug Screening for Therapeutic validation
In this episode Fernanda tells us about her journey to be a biologist and her studies in arachnids and spider venom.
Read more about Fernanda (University of Queensland) here.
Connect with Fernanda on LinkedIn and Twitter. See the updates on her latest research on Google Scholar and ResearchGate.
Benjamin Lane (University of Leeds)
Benjamin is a Wellcome trust PhD student, who is working under the supervision of Dr Christos Pliotas and Dr Stephen Muench. He recently joined their groups to work on his project combining Cryo-EM and PELDOR with electrophysiology, to structurally and functionally characterise novel mechanosensitive ion channels.
Find Benjamin on Twitter and connect with him on LinkedIn.
Catherine Webley (University College London)
In this edition of the podcast - we speak to Catherine Webley, Master of Chemistry, who completed a placement in the academic research lab in the Solar Centre at King Abdullah University of Science and Technology under the supervision of Prof. Iain McCulloch. She describes her 'love affair' with how the natural world works and the impact that the recent Nobel Prize winners have had on her.
Connect with Catherine on ResearchGate and LinkedIn.
Beatrice Badone, Ph.D (University of Milano-Bicocca)
Meet: Beatrice Badone, a Ph.D. student at the University of Milano-Bicocca. In the lab, Beatrice currently works with cardiomyocytes - under Professor Paola Coccetti and through the PRIN grant is working on her current project of the hiPSC-derived astrocytes in Alzheimer's Disease; an example of how stem cells can serve as an alternative for screening purposes.
Find Beatrice on Google Scholar and connect with her on LinkedIn.
Claudia Weidling, Ph.D (University of Copenhagen)
Meet: Claudia Weidling, a Ph.D student at the University of Copenhagen. Claudia is working in The Pless Lab situated in Denmark. In this episode Claudia tells us about her recent publication in Nature, her experience being a Ph.D student during a pandemic and what advice she would offer to prospective Ph.D students.
Read the Nature Publication here.
Read more of Claudia's research here "The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium", co-written by H. C. Chua, M. Wulf, C. Weidling, L. P. Rasmussen, S. A. Pless.
Finally, Claudia would like to thank the funding agency, the Independent Research Fund Denmark and gives all credit for the structure to Genetech.
Connect with Claudia on ResearchGate and LinkedIn.
Kerstin Göpfrich, Ph.D. (Max Planck Institute for Medical Research )
Meet: Kerstin Göpfrich, a Marie Skłodowska-Curie Fellow at the Max Planck Institute for Medical Research. Kerstin works on synthetic biology combining DNA nanotechnology and microfluidics to assemble synthetic cells.
You can learn more about Kerstin and her work here
Postdoctoral research fellow Nasreen Choudhury (Rush University Medical Center) - [Voltage-gated calcium channels]
About:
Nasreen Choudhury is a Postdoctoral research fellow at Rush University Medical Center in Chicago,IL.
Their group is studying Alzheimer's disease.
In 2020, her group published the following paper: "Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem".
Damian Bell (Metrion Biosciences) - Part 1: All things Ion Channels
About:
Damian Bell is an experience electrophysiologist - presently he is working at Metrion Biosciences - which is a specialty CRO (services in cardiac safety profiling, cardiac translational assays and neuronal translational assays) based out of Cambridge, UK.
In Part 1: We look at Damian's history in Patch Clamp Electrophysiology and the emergence of automated patch clamp. He has spent time in the pharmaceutical industry with AstraZeneca, GSK, Convergence and Charles River Laboratories.
The Advances in Drug Discovery specifically involving Ion Channel Research and the emergence of higher throughput screening (when compared to traditional Manual Patch Clamp).
Professor Lars Kaestner (Saarland University) - Red Blood Cells
About:
Lars Kaestner is a professor at Saarland University (Saarbrücken, Germany)
In 2013, Lars published the book "Calcium signalling - Approaches and Findings in the Heart and Blood".
Connect with Lars on LinkedIn and on ResearchGate
Trong Shen, from Biomedical Engineering to the World of Finance.
Connect with Trong on LinkedIn
During his time in the lab, Trong was a member of Hinz Lab working closely with Prof. Boris Hinz of University of Toronto. Dr. Hinz explores the biomechanical, molecular and cellular mechanisms regulating tissue repair and regeneration in physiologic wound healing and pathologic organ scarring (fibrosis). His research focuses on activated connective tissue repair cells – myofibroblasts.
Wandi Zhu, Ph.D. (Harvard) - NaChBac and NaV1.7 Pharmacology
Wandi Zhu is a Post Doc Research Fellow at Harvard, where she is currently working with Dr. Calum A. MacRae at the Brigham and Women's Hospital (BWH). She has previously worked with Dr. Jonathan SIlva (Washington University in St. Louis).
Her recent publication in Nature Scientific Reports entitled "Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms" can be downloaded here: Download the article here
To learn more about Automated Patch Clamp Technology and the advantages of high throughput screening click here