Physionic
By Nicolas Verhoeven
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PhysionicJul 01, 2020
Reversing Heart Disease, Creatine on Kidney Health, 5 Life Extending Habits, and More
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Oreos lowering Blood Cholesterol, Science Communication, Mechanisms of Heart Disease, Ft. Dr. Norwitz, Dave Feldman
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Dave's Channel: https://youtu.be/RzG6N8WWufM?si=XNl6HTJ66vUpZ0QT 0:00 - Introduction of Study 3:47 - Introduction to Dr. Nick Norwitz and Dave Feldman 8:31 - Dr. Norwitz details the Oreo Study 31:52 - Problems with Science Communication 1:12:42 - Discussion with Dave Feldman
1:15:20 - Lipid Heart Model of Heart Disease
1:27:28 - Lean Mass Hyper-Responders
1:35:10 - Mechanisms of Action Discussion
Dr. Brad Stanfield: A Discussion of Supplements for Longevity and Health
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Timestamps
0:00 – Introduction 1:05 – Nicotinamide Mononucleotide (NMN) 17:14 – Creatine 20:25 – Collagen Peptides 25:58 – Thoughts on Meta-Analyses 29:18 – Hyaluronic Acid 34:08 – Taurine 37:42 – Thoughts on Mouse Studies 39:55 – Do Blood Markers Matter for Longevity? 42:29 – Trusting Science/Experts 44:05 – Dr. Stanfield’s Motivations for Clinical Education 53:12 – Ending Remarks
Reconsidering Aging, Muscle Growth, Niacin Supplementation, Your Questions, and More
*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction 5:11 - How to think about Aging 33:48 - Oxidized Blood Lipoproteins 58:34 - Study shows Age Reversal 1:15:28 - Oxalates 1:28:28 - Creatine as a Nootropic 1:35:48 - Niacin and Heart Disease 2:13:17 - Methylene Blue 2:25:25 - NMN on Health 2:38:46 - Inflammation contributing to Heart Disease 2:50:39 - Understanding Cellular Energy for Muscle Growth 3:07:08 - Subscriber Questions & Comments 3:42:05 - Housekeeping
Carnivore Diet, LDL Cholesterol, Fasting & Inflammation, Taurine on Longevity, and much more...
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Table of Content
0:00 - Introduction
05:18 - Carnivore Diet
34:39 - LDL Cholesterol & Heart Disease
1:00:11 - Taurine on Longevity & Health
1:13:04 - One Meal a Day - Context Matters
1:22:27 - Fiber - Good or Bad? Mixed Reviews...
1:38:10 - Cancer is a Metabolic Disease?
2:07:10 - Fasting raises Inflammation!?
2:16:52 - Q&A
2:37:23 - Stories of Health Success
2:44:22 - My PhD Progress, Life outside of University
Insulin on Fat Loss, GlyNAC for Anti-Aging, The Physionic Dream.
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0:00 – Introduction.
5:30 – Toxic Acrylamides in Coffee.
18:46 – The Physionic Dream.
50:05 – Sucralose and Insulin Sensitivity.
57:00 – Insulin & Body Fat.
1:23:25 – Carbohydrate-Insulin Model of Obesity.
2:17:35 – GlyNAC for Anti-Aging.
2:29:50 – Hyaluronic Acid on Skin Aging.
2:40:45 – The Future Content.
Removing my John Campbell Video, High Intensity Health, Sweeteners break your Fast?, and More.
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0:00 - Introduction.
3:00 - Dr. John Campbell, High Intensity Health.
39:40 - Nutrition Gurus.
53:00 - My Investigation on Non-Nutritive Sweeteners.
1:03:05 - Improving the 'Detailed Study Analyses'.
1:09:53 - Sweeteners break your Fast?
1:14:23 - Alternate Day Fasting.
My High Blood Pressure Experience; Plastics impact on Insulin Resistance.
Hi, in this episode, I cover a bunch of topics from my experience at the doctor, my own hypocrisy, some things I learned from you, and finally - the main topic of discussion: Insulin resistance and how plastics (phthalates) affect it. Oh, and if you're on Spotify or YouTube, it's now a video podcast, as well!
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Issues with Nutrition Documentaries; Caffeine and Performance - They Don't Always Mix.
Hi folks, in this episode I unintentionally discussed two topics. One, I planned on discussing, which was caffeine and it's performance effects in weight lifting and endurance. However, because I woke myself up to a nutrition documentary that I watched for 20 minutes or so before recording, I felt I had to get some things off my chest related to the second topic - nutrition documentaries. So, you have the distinct pleasure (or dismay) of listening to me ramble on both, but I hope that either way you learn something of use, especially related to caffeine.
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Video and Studies on Caffeine: https://youtu.be/9WTbwlU5yOs
Nutrition & Pharmaceutical Therapies: Fat related Cancers
In this episode, the first of a more relaxed, long form podcast style, we're going to dive into how fat relates to cancers - the mechanisms, but beyond that, the different therapies employed by pharmaceuticals, along with the use of nutrition to combat certain cancers.
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Related Videos:
Mechanisms: https://youtu.be/Ijt1lqxn2AQ
Therapies: https://youtu.be/iLdcoIIiByo
Scientific Review:
Reprogramming of Fatty Acid Metabolism in Cancer
British Journal of Cancer
Let's Change how We do Things Here.
I think you'd be better served if we change how we do things on the Physionic Podcast.
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Carbohydrates slow Metabolism and Mitochondrial Breathing.
In this episode, I'm going to begin the explanation as to what effects carbohydrates have on our metabolism, and one potential effect in our mitochondria.
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs34%5D-a-high-carbohydrate-diet-lowers-the-rate-of-adipose-tissue-mitochondrial-respiration
Video: https://www.youtube.com/watch?v=7uBHNUSI6hI
Previous Video on Carbs and Metabolism: https://www.youtube.com/watch?v=xn8VJzGCK5U&t=2s
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Study:
A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration
Benjamin Bikman
An Exception to the Insulin Sensitivity Effects of Saturated Fat [Study 31]
In this episode, we'll discuss a potential exception to the negative results on insulin sensitivity we've been discussing with the exposure to saturated fat.
Study, Notes, & Amendments: https://www.physionic.org/examine/%5B31%5D-palmitate-acutely-induces-insulin-resistance-in-isolated-muscle-from-obese-but-not-lean-humans
Video: https://youtu.be/ldUBG4-EJDo
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Study:
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
A Brianne Thrush
Mitochondria & Diabetes: How Nutrition Connects the Two. [Study 32]
Hi all, in this episode, I'm going to describe to you how your nutrition, generally, affects your mitochondria in diabetes specific cells and how long term habits in nutrition can lead to diabetes (type 2). Enjoy.
Video Version: https://youtu.be/x6EOhTzVKsE
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure
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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa
Your Nutrition affects your Mitochondria (Fasting vs Overconsumption) [Study 32]
In this episode, we'll be diving into two ways your mitochondria change their "behavior" to the exposure to different nutrition situations (high vs low nutrient presence).
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure
Video: https://www.youtube.com/watch?v=KQBmtzT4VTU
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Study:
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
Marc Liesa
Saturated vs Unsaturated Fats: One is Worse for Insulin Resistance [Study 30]
In this episode, we'll be going over a new study that wanted to find out the effects a saturated fat heavy consumption would have on insulin resistance and signaling against an unsaturated fat heavy consumption.
Video: https://youtu.be/QfII7CANt14
Study: https://www.physionic.org/examine/%5Bs30%5D-dietary-palmitate-and-oleate-differently-modulate-insulin-sensitivity-in-human-skeletal-muscle
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Sarabhai, T., Koliaki, C., Mastrototaro, L., Kahl, S., Pesta, D., Apostolopoulou, M., Wolkersdorfer, M., Bönner, A. C., Bobrov, P., Markgraf, D. F., Herder, C., & Roden, M. (2022). Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia, 65(2), 301–314. https://doi.org/10.1007/s00125-021-05596-z
Unsaturated Fat to the Rescue: Insulin Signaling and Mitochondrial Health [Study 28]
In this episode, we continue our quest for understanding the effect saturated fats have on muscle insulin signaling and mitochondrial health - however, beyond that, we'll be looking at how unsaturated fats may protect against the deleterious effects of saturated fat? Let's see..
Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs28%5D-different-effects-of-oleate-vs.-palmitate-on-mitochondrial-function%2C-apoptosis%2C-and-insulin-signaling-in-l6-skeletal-muscle-cells%3A-role-of-oxidative-stress-
Video: https://youtu.be/TiO16KoH0Fs
Study Title: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Larysa Yuzefovych
Saturated Fat - Friend or Foe for Insulin Sensitivity and Mitochondrial Function? [Study 27]
In this episode, I'm kicking off a new format that's more tailored to the podcast listeners, so there's less need to head to the video versions of the podcast to understand half of what I'm talking about. In this episode, we'll be discussing saturated fat (palmitate) and it's effects in relation to insulin signaling in muscle cells, as well as mitochondrial function. What are the effects? What are the implications?
Video: https://youtu.be/zMkV91E2Bic
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249685/
Body Fat is lost from THIS - NOT HORMONES
In this episode, I attempt to make sense of calories in vs out and reconcile that with the hormone argument for fat loss.
Video Podcast: https://youtu.be/x1ZjjDzCdc0
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THIS is how Mitochondria DESTROY your Cells.
Mitochondria have a dark side, find out how.
Video Podcast: https://www.youtube.com/watch?v=HPx7cv1I7eU
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Long Term Effects from Fat Loss - Hormones, Weight Regain? [Study Breakdown]
In this podcast, we look at a study that investigates how weight loss affects hormones and long term weight regain - is the deck stacked against you?
Study: https://www.nejm.org/doi/full/10.1056/nejmoa1105816
Video Podcast: https://youtu.be/-t5d0S5MRwE
0:00 - Introduction
2:47 - Study Design
6:58 - Weight Loss & Weight Regain Results
9:45 - Long Term Hormonal Changes from Weight Loss
34:12 - Conclusions/Take Aways
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Does Intermittent Fasting, WITHOUT WEIGHT LOSS, improve your Health? [Study Breakdown]
How does intermittent fasting affect your health, even when you do not lose weight with it? Let's find out.
Study: https://pubmed.ncbi.nlm.nih.gov/29754952/#:~:text=Men%20with%20Prediabetes-,Early%20Time%2DRestricted%20Feeding%20Improves%20Insulin%20Sensitivity%2C%20Blood%20Pressure%2C,Cell%20Metab.
Video Podcast: https://youtu.be/1t0HUSlFNiQ
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0:00 - Introduction
3:23 - Study Design
9:03 - Intermittent Fasting on Health Results
18:24 - "Fasting Increases Inflammation"
20:08 - Intermittent Fasting on Health Continued
23:00 - Conclusions/Take Aways
You asked for it: My Lifetime Workout Routine, Health Habits, and Supplements
Title says it all...
Video Podcast: https://youtu.be/u4XirePJKfg
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Sirtuins, Mitochondria, and Insulin Resistance
In this episode, we'll be discussing how sirtuins play their role in mitochondrial health and insulin resistance.
Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432223/
Video Podcast: https://youtu.be/M9INrzrfsu4
0:00 - Introduction
3:10 - Diabetes Background
8:30 - Mitochondria Background
13:33 - Mitochondria & Insulin Resistance
20:33 - Sirtuins
43:40 - Conclusions/Take Aways
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Creatine on Brain Health; Supplementation & an Alternative?
In this episode, I summarize the content from a brand new scientific review that discusses the difference between creatine supplementation for the brain vs the rest of the body, as well as a possible alternative.
Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916590/
Video Podcast: https://youtu.be/gltKZA6JQr0
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Compensation Theory: Why We should Stop Outrunning our Fat
In this episode, I cover a study sent to me by a subscriber wherein the researchers discuss a new model for understanding metabolism through their self titled 'Compensation Hypothesis'.
Study: https://www.sciencedirect.com/science/article/pii/S0960982221011209
Video Podcast: https://youtu.be/O7TY-HMZkKA
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Does your metabolism decline after 30?
In this podcast, I'll be detailing a brand new study deeply investigating the decline in metabolism with age.
Study: https://science.sciencemag.org/content/373/6556/808
Video Podcast: https://youtu.be/cXHxl8dPqG0
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0:00 - Introduction
6:02 - Metabolism over the Lifespan
13:35 - 2 Factors that lead to Metabolism Decline?
23:58 - Conclusion/Take Aways
Is Keto Right for Women's Health? [2 Studies]
In this episode, we'll dive into two very similar studies trying to distinguish the effect of the ketogenic diet on cholesterol, blood sugar, insulin, and blood fats (triglycerides).
Video Podcast: https://youtu.be/yx2OuoMZBFg
Study A: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001988/pdf/nutrients-13-00814.pdf
Study B: https://pubmed.ncbi.nlm.nih.gov/12949361/
0:00 - Introduction
3:40 - Study Design
12:18 - Keto on Cholesterol
20:07 - Keto on Blood Sugar & Insulin
22:25 - Keto on Triglycerides
24:05 - Discussing the Results
37:48 - Conclusions/Take Aways
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16/8 Intermittent Fasting, without Calorie Counting, on Weight & Health
In this episode, we'll dissect a study wherein the researchers attempt to find out how an unrestricted intermittent fasting protocol works for overweight individuals in aspects of weight, muscle, metabolism, and cardiovascular outcomes like cholesterol, blood sugar, insulin, and so on.
Video Podcast: https://youtu.be/TjEKr7ysbfI
Study: https://pubmed.ncbi.nlm.nih.gov/32986097/
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0:00 - Introduction
5:33 - Study Design
7:26 - Could they Stick to IF?
9:22 - Individual Weight Loss
11:16 - Total Weight Loss
14:40 - Body Composition (Muscle, Fat, etc.)
21:19 - Metabolism
23:25 - Blood Sugar, Insulin, Cholesterol, etc.
26:31 - Conclusions/Take Aways
Questions & Answers: Protein Threshold, Origin of CoVID, Protein on Lifespan, and More.
This week, I return by simply answering questions you guys sent me on Instagram and YouTube.
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0:00 - Introduction
2:35 - Thank you
5:25 - Limited Protein Absorption
8:04 - Protein on Lifespan
12:09 - Ideal Body Fat for Testosterone
14:25 - Threshold that Muscle Stops Protein Synthesis
17:40 - Creatine Bloat
20:48 - Origin of the Virus
Protein for Optimal Muscle Growth: Type, Timing, Amount, and More
In this episode, I cover a scientific review on the literature of protein for muscle growth. We'll be covering protein total amount, timing, type, differences in men and women, aging, and more. Enjoy.
Video Podcast: https://youtu.be/7h-kLKmknEo
Scientific Review: https://link.springer.com/article/10.1007/s40279-019-01053-5
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Elevated Blood Fats Change our Mitochondria Behavior & Autophagy
In this episode, we investigate how elevated blood fats change how our mitochondria "behave" and its affect on autophagy.
Video Podcast: https://youtu.be/g6JJzVkYM7I
Study: https://www.sciencedirect.com/science/article/abs/pii/S0026049521001037
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Saturated vs Unsaturated Keto on Cholesterol & Insulin Sensitivity [Starting to get Answers]
In this podcast, I dive deeper into yet another study comparing the ketogenic diet for blood cholesterol, with the added bonus of briefly touching on insulin sensitivity. In this episode, we start to recognize the key difference between a healthy ketogenic diet and an unhealthy ketogenic diet.
Study: https://pubmed.ncbi.nlm.nih.gov/15070924/
Video Podcast: https://youtu.be/KEcyW496KGA
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Ketogenic Diet increases Cholesterol in Healthy Women
In this episode, we'll be going again into the ketogenic diet, but the context hath changed as the people being tested are healthy and young, non-overweight, unlike previous studies. There are some other caveats, as well, that we'll go into, so buckle up and let's dive in.
Study: https://pubmed.ncbi.nlm.nih.gov/30408717/
Video Podcast: https://youtu.be/bX1cax3zvfQ
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Intermittent Fasting + Exercise on Muscle, Fat, Blood Sugar, Inflammation & More
In this episode, we dive into a study looking at how 16 hour intermittent fasting affects a variety of health outcomes when paired with resistance training in non-beginner lifters.
Study: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1044-0
Video Podcast: https://youtu.be/2B99DJwPMCk
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Overweight? High Cholesterol? High Blood Sugar? Keto it away.
In this episode, the 'keto hater' takes on a study that simply investigates the effects from the ketogenic diet in bodyweight, cholesterol, and blood sugar in people who are overweight.
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/pdf/ecc09200.pdf
Video Podcast: https://youtu.be/bsH1qubGSB8
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The End Replication Problem (Telomeres) & Cellular Senescence
In this episode, we'll be beginning our look at senescent cells, how and why they occur, as well as the main drivers of senescence in aging and disease.
Video Podcast: https://youtu.be/NcBpJv5WIhY
Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/pdf/JCB_201708092.pdf
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How do Saturated Fats affect Mitochondria?
In this episode, we'll be discussing how different types of saturated and unsaturated fats impact mitochondria in our muscle cells.
Video Podcast: https://youtu.be/2T9I1FmlFyE
Study: https://link.springer.com/content/pdf/10.1007/s00125-005-1895-z.pdf
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The 'Keto Damages the Heart' Critique, and My Nutrition
In this episode, I discuss some of the valid and non-valid (by my estimation) critiques of the recent ketogenic diet study I covered on the YouTube channel. I also discuss the nutrition style that I follow, specifically.
Video Podcast: https://youtu.be/eE2QpdRSeFY
Keto Damages the Heart Video: https://youtu.be/CAkjoT28yZw
Keto Damages the Heart Podcast: https://youtu.be/lpns8gfR3H8
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Emilin Deficiency leads to High Blood Pressure
In this episode, I discuss a study looking at how a protein (Emilin) and a molecule (TGF-beta) create a scenario in which high blood pressure occurs in animals *and* in the same effect is seen in humans with high blood pressure.
Study: https://pubmed.ncbi.nlm.nih.gov/30354220/
Video Podcast: https://youtu.be/88GqvZ2XjrM
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Why Cancer feeds on Sugar
In this episode, I discuss how, and potential reasons why, cancer cells feed off sugar/glucose.
Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783224/
Video Podcast: https://youtu.be/vszypCVgpaE
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How does Alcohol affect your Muscle Growth? Let's discuss the Data.
In this episode, we go into a study that investigates if alcohol affects our muscle growth potential by specifically looking at muscle protein synthesis, as well as some proxy markers of protein breakdown.
Study: https://pubmed.ncbi.nlm.nih.gov/24533082/
Video Podcast: https://youtu.be/CaRPAx9gL4U
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I Published a Study (On a New Mechanism for Autophagy)
This is an involved one, but if you care to join me as I explain my recent publication with my lab wherein we discover and describe a new pathway by which autophagy is mediated in cells, then you'll learn some cutting edge science.
My Study: https://www.researchgate.net/publication/350870898_Parkin-independent_mitophagy_via_Drp1-mediated_outer_membrane_severing_and_inner_membrane_ubiquitination
Video Podcast: https://youtu.be/QmX5xN3H7aU
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A Medical Research Lecture on Heart Aneurysms [Marfan Syndrome]
This podcast gets really nitty gritty in that it discusses the intracellular signaling pathways and the association between smooth muscle cells and a protein rich foundation known as the extracellular matrix - what causes this weakness in the aorta of the vascular system leading to aneurysm formation? Find out.
Study: https://youtu.be/YlQtTdj2eLo
Video Podcast: https://youtu.be/YlQtTdj2eLo
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Excessive Exercise changes how our Mitochondria behave? [Mitochondrial Dynamics] 2
In this episode, we finish up from last week by discussing how mitochondrial "behavior" is affected by excessive exercise, as well as its impact on mitochondrial reactive oxygen generation, which can cause damage to our cells.
Study: https://www.sciencedirect.com/science/article/abs/pii/S1550413121001029?via%3Dihub
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Is too much exercise detrimental to our mitochondria and blood sugar regulation?
In this episode, I cover a brand spankin' new study wherein the researchers attempt to answer the question of overdoing exercise and its impact on muscle mitochondria, as well as blood sugar regulation.
Study: https://www.sciencedirect.com/science/article/abs/pii/S1550413121001029?via%3Dihub
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Weight Loss and its affect on Metabolic Adaptation
In this episode, we take a look at a study that investigates the impact weight loss/calorie restriction has on metabolic adaptation; we also briefly discuss the idea of metabolic "damage". This is one of a few episodes that I'll be using to cover the topic of metabolic adaptation.
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328781/?fbclid=IwAR3WSvSpNLzgnwfGh_xyAEx4Txh9z91LnjbW2CFrbbzSS0cM-47MGL4eUxU
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Ketogenic Diet & Ketosis leads to Heart Cell Death [Study Breakdown]
In this episode, I take us on a brief breakdown of a study looking at the ketogenic diet and its impact on heart cell death, heart size, and mitochondrial content. Some intriguing, potentially alarming, results here, but we'll see what interpretations we can really make on this data - dive in with me!
Study: https://www.nature.com/articles/s41392-020-00411-4
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Burning More Fat DOES NOT mean losing more BODY FAT
In this episode, I attempt to make it as clear as possible, by comparison of high fat/keto to high carbohydrate diets and how they differ in their ability produce body fat loss, although one promotes greater fat burning/oxidation.
Video Podcast (available at 10am ET): https://youtu.be/Ns0tXvLI-OI
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Metabolic Flexibility: Switching from Carbs to Fat, and Back Again
In this episode, I give a bit of a higher level view on metabolic flexibility - what is it? Why is it important? Instances of it? How to improve it? That's all covered in this podcast - enjoy!
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