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By Ralph Turchiano

My Personal Biomedical Research Feed - Ralph Turchiano, CEO Alchepharma
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Curcumin, Tendinopathy and Myotendinous Junction Injury Episode 1120 JAN 2023
Curcumin, Tendinopathy and Myotendinous Junction Injury Episode 1120 JAN 2023
“Curcumin seems to preserve, and even repair, damaged tendons. In this systematic review, we focus more especially on the benefits of curcumin.” #curcumin #tendon #tendinopathy Córdova A, Drobnic F, Noriega-González D, Caballero-García A, Roche E, Alvarez-Mon M. Is Curcumine Useful in the Treatment and Prevention of the Tendinopathy and Myotendinous Junction Injury? A Scoping Review. Nutrients. 2023; 15(2):384. https://doi.org/10.3390/nu15020384 Curcumin, tendon, tendinopathy, collagen, type 1, inflammation, substance p, Curcuma longa, Myotendinous Junction Injury, prevention, repair, regeneration, leukocytes, Curcumine, crosslinking, antialgic Curcumin, Tendinopathy and Myotendinous Junction Injury Episode 1120 JAN 2023 #curcumin #tendon #tendinopathy #myotendinous #repair #regeneration
14:03
January 29, 2023
Curcumin, Tendinopathy and Myotendinous Junction Injury Episode 1120 JAN 2023
Curcumin, Tendinopathy and Myotendinous Junction Injury Episode 1120 JAN 2023
“Curcumin seems to preserve, and even repair, damaged tendons. In this systematic review, we focus more especially on the benefits of curcumin.” #curcumin #tendon #tendinopathy Córdova A, Drobnic F, Noriega-González D, Caballero-García A, Roche E, Alvarez-Mon M. Is Curcumine Useful in the Treatment and Prevention of the Tendinopathy and Myotendinous Junction Injury? A Scoping Review. Nutrients. 2023; 15(2):384. https://doi.org/10.3390/nu15020384 Curcumin, tendon, tendinopathy, collagen, type 1, inflammation, substance p, Curcuma longa, Myotendinous Junction Injury, prevention, repair, regeneration, leukocytes, Curcumine, crosslinking, antialgic Curcumin, Tendinopathy and Myotendinous Junction Injury Episode 1120 JAN 2023 #curcumin #tendon #tendinopathy #myotendinous #repair #regeneration
14:03
January 29, 2023
Brazilian Propolis Lean Muscle Mass and Body Fat Loss Episode 1119 JAN 2023
Brazilian Propolis Lean Muscle Mass and Body Fat Loss Episode 1119 JAN 2023
Brazilian Propolis Lean Muscle Mass and Body Fat Loss Episode 1119 JAN 2023 Taken together, a lower fat mass, as observed in this study, may be accounted for by a higher lipolytic capacity in adipocytes and skeletal muscles. In addition, another possible explanation for reduced fat mass may be attributed to the positive effect of propolis on skeletal muscle mass, resulting in increased energy expenditure through the basal metabolic rate. #propolis #lean muscle #fatloss Kanazashi, M.; Iida, T.; Nakanishi, R.; Tanaka, M.; Ikeda, H.; Takamiya, N.; Maeshige, N.; Kondo, H.; Nishigami, T.; Harada, T.; Fujino, H. Brazilian Propolis Intake Decreases Body Fat Mass and Oxidative Stress in Community-Dwelling Elderly Females: A Randomized Placebo-Controlled Trial. Nutrients 2023, 15, 364. https://doi.org/10.3390/nu15020364 Propolis, Artepillin C, brown fat, skeletal muscle, lean muscle, fat loss, metabolism, green propolis, Brazilian green propolis, adipocytes, peroxisome proliferator-activated receptor, AMPK, PPARγ, activated protein kinase, diet, elderly, fragile Brazilian Propolis Lean Muscle Mass and Body Fat Loss #propolis #greenpropolis #leanmuscle #metabolism #leanbodymass #elderly #brownfat #artepillin
09:25
January 22, 2023
Brazilian Propolis Lean Muscle Mass and Body Fat Loss Episode 1119 JAN 2023
Brazilian Propolis Lean Muscle Mass and Body Fat Loss Episode 1119 JAN 2023
Brazilian Propolis Lean Muscle Mass and Body Fat Loss Episode 1119 JAN 2023 Taken together, a lower fat mass, as observed in this study, may be accounted for by a higher lipolytic capacity in adipocytes and skeletal muscles. In addition, another possible explanation for reduced fat mass may be attributed to the positive effect of propolis on skeletal muscle mass, resulting in increased energy expenditure through the basal metabolic rate. #propolis #lean muscle #fatloss Kanazashi, M.; Iida, T.; Nakanishi, R.; Tanaka, M.; Ikeda, H.; Takamiya, N.; Maeshige, N.; Kondo, H.; Nishigami, T.; Harada, T.; Fujino, H. Brazilian Propolis Intake Decreases Body Fat Mass and Oxidative Stress in Community-Dwelling Elderly Females: A Randomized Placebo-Controlled Trial. Nutrients 2023, 15, 364. https://doi.org/10.3390/nu15020364 Propolis, Artepillin C, brown fat, skeletal muscle, lean muscle, fat loss, metabolism, green propolis, Brazilian green propolis, adipocytes, peroxisome proliferator-activated receptor, AMPK, PPARγ, activated protein kinase, diet, elderly, fragile Brazilian Propolis Lean Muscle Mass and Body Fat Loss #propolis #greenpropolis #leanmuscle #metabolism #leanbodymass #elderly #brownfat #artepillin
09:25
January 22, 2023
Natural Compounds and Radiation Injury Episode 1118 JAN 2023
Natural Compounds and Radiation Injury Episode 1118 JAN 2023
Natural Compounds and Radiation Injury The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy. #radiation #mucositis, #natural Altomare, A.; Fiore, M.; D’Ercole, G.; Imperia, E.; Nicolosi, R.M.; Della Posta, S.; Pasqua, G.; Cicala, M.; De Gara, L.; Ramella, S.; Guarino, M.P.L. Protective Role of Natural Compounds under Radiation-Induced Injury. Nutrients 2022, 14, 5374. https://doi.org/10.3390/nu14245374 Radiation, Protective Compounds, Protective Plant Compounds, Natural, Ionizing radiation. ROS, Mucositis, radiotherapy induced mucositis, gamma radiation exposure, DNA, propolis, lutein, quercetin, egcg, rosmarinic acid, Chlorogenic Acid, Cinnamic Acid, Gallic Acid, reactive oxygen species, radiation exposure, radiation illness
16:25
January 15, 2023
Natural Compounds and Radiation Injury Episode 1118 JAN 2023
Natural Compounds and Radiation Injury Episode 1118 JAN 2023
Natural Compounds and Radiation Injury The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy. #radiation #mucositis, #natural Altomare, A.; Fiore, M.; D’Ercole, G.; Imperia, E.; Nicolosi, R.M.; Della Posta, S.; Pasqua, G.; Cicala, M.; De Gara, L.; Ramella, S.; Guarino, M.P.L. Protective Role of Natural Compounds under Radiation-Induced Injury. Nutrients 2022, 14, 5374. https://doi.org/10.3390/nu14245374 Radiation, Protective Compounds, Protective Plant Compounds, Natural, Ionizing radiation. ROS, Mucositis, radiotherapy induced mucositis, gamma radiation exposure, DNA, propolis, lutein, quercetin, egcg, rosmarinic acid, Chlorogenic Acid, Cinnamic Acid, Gallic Acid, reactive oxygen species, radiation exposure, radiation illness
16:25
January 15, 2023
Lactoferrin anti-viral powerhouse Episode 1117 JAN 2023
Lactoferrin anti-viral powerhouse Episode 1117 JAN 2023
Lactoferrin anti-viral powerhouse Episode 1117 JAN 2023 Although LF has several biological benefits, the host-protective effects against pathogens including viruses, bacteria, and fungi are regarded as one of its most beneficial [83]. Several reviews have highlighted the in vitro anti-viral effects of LF against pathogens that cause common infections such as influenza, the common cold, summer cold, gastroenteritis, polio, and herpes. #antiviral #lactoferrin #antimicrobial Einerhand, A.W.C.; van Loo-Bouwman, C.A.; Weiss, G.A.; Wang, C.; Ba, G.; Fan, Q.; He, B.; Smit, G. Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19? Nutrients 2022, 14, 5274. https://doi.org/10.3390/nu14245274 Lactoferrin, anti-viral, anti-microbial, iron-binding, immunomodulatory, microbiota-modulatory, covid, sars, B-cell differentiation, total T-cell activation, T-helper cell activation, cytotoxic T-cell activation, SARS-CoV-2, influenza, the common cold, summer cold, gastroenteritis, polio, herpes, iron binding Lactoferrin anti-viral powerhouse #lactoferrin #sarscov2 #antiviral #antimicrobial #covid19 #nutraceutical #bovine#polio #herpes #commoncold#influenza
16:02
January 08, 2023
Lactoferrin anti-viral powerhouse Episode 1117 JAN 2023
Lactoferrin anti-viral powerhouse Episode 1117 JAN 2023
Lactoferrin anti-viral powerhouse Episode 1117 JAN 2023 Although LF has several biological benefits, the host-protective effects against pathogens including viruses, bacteria, and fungi are regarded as one of its most beneficial [83]. Several reviews have highlighted the in vitro anti-viral effects of LF against pathogens that cause common infections such as influenza, the common cold, summer cold, gastroenteritis, polio, and herpes. #antiviral #lactoferrin #antimicrobial Einerhand, A.W.C.; van Loo-Bouwman, C.A.; Weiss, G.A.; Wang, C.; Ba, G.; Fan, Q.; He, B.; Smit, G. Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19? Nutrients 2022, 14, 5274. https://doi.org/10.3390/nu14245274 Lactoferrin, anti-viral, anti-microbial, iron-binding, immunomodulatory, microbiota-modulatory, covid, sars, B-cell differentiation, total T-cell activation, T-helper cell activation, cytotoxic T-cell activation, SARS-CoV-2, influenza, the common cold, summer cold, gastroenteritis, polio, herpes, iron binding Lactoferrin anti-viral powerhouse #lactoferrin #sarscov2 #antiviral #antimicrobial #covid19 #nutraceutical #bovine#polio #herpes #commoncold#influenza
16:02
January 08, 2023
Bifidobacterium longum BB68S Cognition Enhancement Super Star Episode #1116 DEC 2022
Bifidobacterium longum BB68S Cognition Enhancement Super Star Episode #1116 DEC 2022
BB68S significantly improved subjects’ cognitive functions (total RBANS score increased by 18.89 points after intervention, p less than 0.0001), especially immediate memory, visuospatial/constructional, attention, and delayed memory domains. BB68S intervention increased the relative abundances of beneficial bacteria Lachnospira, Bifidobacterium, Dorea, and Cellulosilyticum, while decreasing those of bacteria related to cognition impairment, such as Collinsella, Parabacteroides, Tyzzerella, Bilophila, unclassified_c_Negativicutes, Epulopiscium, Porphyromonas, and Granulicatella. #BifidobacteriumlongumBB68S #memory #probiotic Shi, S.; Zhang, Q.; Sang, Y.; Ge, S.; Wang, Q.; Wang, R.; He, J. Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2023, 15, 51. https://doi.org/10.3390/nu15010051 Bifidobacterium longum BB68S, RBANS, Cognition, immediate memory, visuospatial, attention, delayed memory, Repeatable Battery for the Assessment of Neuropsychological Status, human enhancement, memory enhancement, probiotic intervention, microbiota, Cognitive Functions
14:34
January 01, 2023
Bifidobacterium longum BB68S Cognition Enhancement Super Star Episode #1116 DEC 2022
Bifidobacterium longum BB68S Cognition Enhancement Super Star Episode #1116 DEC 2022
Bifidobacterium longum  BB68S Cognition Enhancement Super Star Episode #1116 DEC 2022 BB68S significantly improved subjects’ cognitive functions (total RBANS score increased by 18.89 points after intervention, p less than 0.0001), especially immediate memory, visuospatial/constructional, attention, and delayed memory domains. BB68S intervention increased the relative abundances of beneficial bacteria Lachnospira, Bifidobacterium, Dorea, and Cellulosilyticum, while decreasing those of bacteria related to cognition impairment, such as Collinsella, Parabacteroides, Tyzzerella, Bilophila, unclassified_c_Negativicutes, Epulopiscium, Porphyromonas, and Granulicatella. #BifidobacteriumlongumBB68S #memory #probiotic Shi, S.; Zhang, Q.; Sang, Y.; Ge, S.; Wang, Q.; Wang, R.; He, J. Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2023, 15, 51. https://doi.org/10.3390/nu15010051 Bifidobacterium longum BB68S, RBANS, Cognition, immediate memory, visuospatial, attention, delayed memory, Repeatable Battery for the Assessment of Neuropsychological Status, human enhancement, memory enhancement, probiotic intervention, microbiota, Cognitive Functions
17:31
January 01, 2023
Time Restricted Eating Metabolic Benefits Episode 1115 DEC 2022
Time Restricted Eating Metabolic Benefits Episode 1115 DEC 2022
Time-restricted Eating for the Prevention and Management of Metabolic Diseases In pilot human studies, TRE with or without explicit calorie reduction can reduce body weight, glucose intolerance, hypertension, and dyslipidemia. Manoogian ENC, Chow LS, Taub PR, Laferrère B, Panda S. Time-restricted Eating for the Prevention and Management of Metabolic Diseases. Endocr Rev. 2022 Mar 9;43(2):405-436. doi: 10.1210/endrev/bnab027. PMID: 34550357; PMCID: PMC8905332. #TRE #Timerestrictedeating #melatonin Intermittent fasting may reverse type 2 diabetes, according to study The researchers conducted a 3-month intermittent fasting diet intervention among 36 people with diabetes and found almost 90% of participants, including those who took blood sugar-lowering agents and insulin, reduced their diabetes medication intake after intermittent fasting. Fifty-five percent of these people experienced diabetes remission, discontinued their diabetes medication and maintained it for at least one year. Xiao Yang, Jiali Zhou, Huige Shao, Bi Huang, Xincong Kang, Ruiyu Wu, Fangzhou Bian, Minghai Hu, Dongbo Liu, Effect of an Intermittent Calorie-restricted Diet on Type 2 Diabetes Remission: A Randomized Controlled Trial, The Journal of Clinical Endocrinology & Metabolism, 2022;, dgac661, https://doi.org/10.1210/clinem/dgac661 TRE, CMNT, Time restricted eating, time restricted feeding, reduce body weight, glucose intolerance, hypertension,  dyslipidemia, diet, intermittent fasting, diabetes, blood sugar, type 2, Chinese Medical Nutrition Therapy, melatonin, circadian rhythm, metabolic diseases, cardiac health, heart health, sleep cycles, best time to eat
17:31
December 25, 2022
Time Restricted Eating Metabolic Benefits Episode 1115 DEC 2022
Time Restricted Eating Metabolic Benefits Episode 1115 DEC 2022
Time-restricted Eating for the Prevention and Management of Metabolic Diseases In pilot human studies, TRE with or without explicit calorie reduction can reduce body weight, glucose intolerance, hypertension, and dyslipidemia. Manoogian ENC, Chow LS, Taub PR, Laferrère B, Panda S. Time-restricted Eating for the Prevention and Management of Metabolic Diseases. Endocr Rev. 2022 Mar 9;43(2):405-436. doi: 10.1210/endrev/bnab027. PMID: 34550357; PMCID: PMC8905332. #TRE #Timerestrictedeating #melatonin Intermittent fasting may reverse type 2 diabetes, according to study The researchers conducted a 3-month intermittent fasting diet intervention among 36 people with diabetes and found almost 90% of participants, including those who took blood sugar-lowering agents and insulin, reduced their diabetes medication intake after intermittent fasting. Fifty-five percent of these people experienced diabetes remission, discontinued their diabetes medication and maintained it for at least one year. Xiao Yang, Jiali Zhou, Huige Shao, Bi Huang, Xincong Kang, Ruiyu Wu, Fangzhou Bian, Minghai Hu, Dongbo Liu, Effect of an Intermittent Calorie-restricted Diet on Type 2 Diabetes Remission: A Randomized Controlled Trial, The Journal of Clinical Endocrinology & Metabolism, 2022;, dgac661, https://doi.org/10.1210/clinem/dgac661 TRE, CMNT, Time restricted eating, time restricted feeding, reduce body weight, glucose intolerance, hypertension,  dyslipidemia, diet, intermittent fasting, diabetes, blood sugar, type 2, Chinese Medical Nutrition Therapy, melatonin, circadian rhythm, metabolic diseases, cardiac health, heart health, sleep cycles, best time to eat
17:31
December 25, 2022
Blue Light Therapy and PTSD Episode 1114 Fall 2022
Blue Light Therapy and PTSD Episode 1114 Fall 2022
“The data are thrilling,” said Jordan Karp, MD, professor and chair of the College of Medicine – Tucson’s Department of Psychiatry. “This nonpharmacological intervention is a promising life-changing and life-saving possibility for people suffering from PTSD.” John R. Vanuk, Edward F. Pace-Schott, Ayla Bullock, Simon Esbit, Natalie S. Dailey, William D. S. Killgore. Morning blue light treatment improves sleep complaints, symptom severity, and retention of fear extinction memory in post-traumatic stress disorder. Frontiers in Behavioral Neuroscience, 2022; 16 DOI: 10.3389/fnbeh.2022.886816 #BLT #Bluelight #PTSD Blue light, 469nm, ptsd, fear extinction, sleep, fear expression, morning light, therapy, post-traumatic stress disorder. Bly, trauma, post-traumatic stress disorder, circadian rhythm
08:28
December 18, 2022
Blue Light Therapy and PTSD Episode 1114 Fall 2022
Blue Light Therapy and PTSD Episode 1114 Fall 2022
“The data are thrilling,” said Jordan Karp, MD, professor and chair of the College of Medicine – Tucson’s Department of Psychiatry. “This nonpharmacological intervention is a promising life-changing and life-saving possibility for people suffering from PTSD.” John R. Vanuk, Edward F. Pace-Schott, Ayla Bullock, Simon Esbit, Natalie S. Dailey, William D. S. Killgore. Morning blue light treatment improves sleep complaints, symptom severity, and retention of fear extinction memory in post-traumatic stress disorder. Frontiers in Behavioral Neuroscience, 2022; 16 DOI: 10.3389/fnbeh.2022.886816 #BLT #Bluelight #PTSD Blue light, 469nm, ptsd, fear extinction, sleep, fear expression, morning light, therapy, post-traumatic stress disorder. Bly, trauma, post-traumatic stress disorder, circadian rhythm
08:28
December 18, 2022
Fat Loss and the New Green Med Diet Episode 1113 Fall 2022
Fat Loss and the New Green Med Diet Episode 1113 Fall 2022
Fat Loss and the New Green Med Diet Episode 1113 Fall 2022 The green Mediterranean diet (MED) significantly reduces visceral adipose tissue, a type of fat around internal organs that is much more dangerous than the extra "tire" around your waist. The green Mediterranean diet was pitted against the Mediterranean diet and a healthy diet in a large-scale clinical interventional trial- the DIRECT PLUS. Subsequent analysis found that the green Med diet reduced visceral fat by 14%, the Med diet by 7% and the healthy diet by 4.5%. The study was published in BMC Medicine. #VAT #duckweed #diet Zelicha, H., Kloting, N., Kaplan, A. et al. The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial. BMC Med 20, 327 (2022). https://doi.org/10.1186/s12916-022-02525-8 Urolithin A, duckweed, VAT, visceral fat tissue, Subcutaneous adipose tissue, visceral adipose tissue, green med diet, Mediterranean diet, waist circumference, polyphenol, Mankai, Wolffia globose, green tea, SAT, green Mediterranean diet, fat loss, heart health
13:06
December 11, 2022
Fat Loss and the New Green Med Diet Episode 1113 Fall 2022
Fat Loss and the New Green Med Diet Episode 1113 Fall 2022
The green Mediterranean diet (MED) significantly reduces visceral adipose tissue, a type of fat around internal organs that is much more dangerous than the extra "tire" around your waist. The green Mediterranean diet was pitted against the Mediterranean diet and a healthy diet in a large-scale clinical interventional trial- the DIRECT PLUS. Subsequent analysis found that the green Med diet reduced visceral fat by 14%, the Med diet by 7% and the healthy diet by 4.5%. The study was published in BMC Medicine. #VAT #duckweed #diet Zelicha, H., Kloting, N., Kaplan, A. et al. The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial. BMC Med 20, 327 (2022). https://doi.org/10.1186/s12916-022-02525-8 Urolithin A, duckweed, VAT, visceral fat tissue, Subcutaneous adipose tissue, visceral adipose tissue, green med diet, Mediterranean diet, waist circumference, polyphenol, Mankai, Wolffia globose, green tea, SAT, green Mediterranean diet, fat loss, heart health
13:06
December 11, 2022
Long Covid Fatigue L-Arginine Liposomal C
Long Covid Fatigue L-Arginine Liposomal C
l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population. #longcovid #arginine #fatigue Tosato M, Calvani R, Picca A, Ciciarello F, Galluzzo V, Coelho-Júnior HJ, Di Giorgio A, Di Mario C, Gervasoni J, Gremese E, Leone PM, Nesci A, Paglionico AM, Santoliquido A, Santoro L, Santucci L, Tolusso B, Urbani A, Marini F, Marzetti E, Landi F on behalf of the Gemelli against COVID-19 Post-Acute Care Team. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial. Nutrients. 2022; 14(23):4984. https://doi.org/10.3390/nu14234984 Long covid, fatigue, arginine, liposomal c, vitamin c, recovery, post-acute COVID-19 syndrome, SARS-CoV-2, 6 min walk test, handgrip strength, flow-mediated dilation, nitric oxide, nutraceuticals, oral supplement, persistent symptoms
13:09
December 04, 2022
Long Covid Fatigue L-Arginine Liposomal C
Long Covid Fatigue L-Arginine Liposomal C
Long Covid Fatigue L-Arginine Liposomal C l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population. #longcovid #arginine #fatigue Tosato M, Calvani R, Picca A, Ciciarello F, Galluzzo V, Coelho-Júnior HJ, Di Giorgio A, Di Mario C, Gervasoni J, Gremese E, Leone PM, Nesci A, Paglionico AM, Santoliquido A, Santoro L, Santucci L, Tolusso B, Urbani A, Marini F, Marzetti E, Landi F on behalf of the Gemelli against COVID-19 Post-Acute Care Team. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial. Nutrients. 2022; 14(23):4984. https://doi.org/10.3390/nu14234984 Long covid, fatigue, arginine, liposomal c, vitamin c, recovery, post-acute COVID-19 syndrome, SARS-CoV-2, 6 min walk test, handgrip strength, flow-mediated dilation, nitric oxide, nutraceuticals, oral supplement, persistent symptoms
13:09
December 03, 2022
Hibiscus Tea Flavonoid may beat Alzheimer's disease Episode 1111 Fall 2022
Hibiscus Tea Flavonoid may beat Alzheimer's disease Episode 1111 Fall 2022
Hibiscus Tea Flavonoid may beat Alzheimer's disease  Episode 1111 Fall 2022 “The research team treated AD model mice with gossypetin through intragastric administration for three months and concluded that their impaired memory and cognition were almost restored to the normal level. (13wk) Furthermore, they saw a decrease in the various types of Aβ aggregates, which are commonly found in the brain tissue with AD-type dementia. #gossypetin #hibiscus #alzheimers Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim, Kyong-Tai Kim. Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ. Alzheimer's Research & Therapy, 2022; 14 (1) DOI: 10.1186/s13195-022-01096-3 Hibiscus, gossypetin, amyloid, tau, flavonoid, alzheimers, microgila, phagocytes, dementia, amyloid-beta, Hibiscus sabdariffa, roselle, ruby red hibiscus, phagocytosis, cognitive decline, memory loss
08:24
November 27, 2022
Hibiscus Tea Flavonoid may beat Alzheimer's disease Episode 1111 Fall 2022
Hibiscus Tea Flavonoid may beat Alzheimer's disease Episode 1111 Fall 2022
“The research team treated AD model mice with gossypetin through intragastric administration for three months and concluded that their impaired memory and cognition were almost restored to the normal level. (13wk) Furthermore, they saw a decrease in the various types of Aβ aggregates, which are commonly found in the brain tissue with AD-type dementia. #gossypetin #hibiscus #alzheimers Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim, Kyong-Tai Kim. Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ. Alzheimer's Research & Therapy, 2022; 14 (1) DOI: 10.1186/s13195-022-01096-3 Hibiscus, gossypetin, amyloid, tau, flavonoid, alzheimers, microgila, phagocytes, dementia, amyloid-beta, Hibiscus sabdariffa, roselle, ruby red hibiscus, phagocytosis, cognitive decline, memory loss
08:24
November 27, 2022
Motivation Increased With NAC / (GSH)
Motivation Increased With NAC / (GSH)
"Our study provides novel insights on how brain metabolism relates to behavior and puts forward nutritional interventions targeting key oxidative process as ideal interventions to facilitate effortful endurance," conclude the authors. The study's findings "suggest that improvement of accumbal antioxidant function may be a feasible approach to boost motivation." #NAC #nucleusaccumbens #motivation Eva Ramos-Fernández, Ioannis Zalachoras, Fiona Hollis, Laura Trovo, João Rodrigues, Alina Strasser, Olivia Zanoletti, Pascal Steiner, Nicolas Preitner, Lijing Xin, Simone Astori, Carmen Sandi. Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort. eLife, 2022; 11 DOI: 10.7554/eLife.77791 NAC, Nucleus Accumbens, motivation, effort , glutathione, N-acetylcysteine, oxidative stress, GSH, persistence, antioxidant, ros, brain, reward, accumbal GSH, behavior, NuAc, accumbal antioxidant, effortful endurance, nutritional interventions
11:56
November 21, 2022
Motivation Increased With NAC / (GSH)
Motivation Increased With NAC / (GSH)
Motivation Increased With NAC / (GSH) "Our study provides novel insights on how brain metabolism relates to behavior and puts forward nutritional interventions targeting key oxidative process as ideal interventions to facilitate effortful endurance," conclude the authors. The study's findings "suggest that improvement of accumbal antioxidant function may be a feasible approach to boost motivation." #NAC #nucleusaccumbens #motivation Eva Ramos-Fernández, Ioannis Zalachoras, Fiona Hollis, Laura Trovo, João Rodrigues, Alina Strasser, Olivia Zanoletti, Pascal Steiner, Nicolas Preitner, Lijing Xin, Simone Astori, Carmen Sandi. Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort. eLife, 2022; 11 DOI: 10.7554/eLife.77791 NAC, Nucleus Accumbens, motivation, effort , glutathione, N-acetylcysteine, oxidative stress, GSH, persistence, antioxidant, ros, brain, reward, accumbal GSH, behavior, NuAc, accumbal antioxidant, effortful endurance, nutritional interventions
11:57
November 13, 2022
Green Glasses may reduce Fear based Anxiety and Opioid Use Episode 1109 Fall 2022
Green Glasses may reduce Fear based Anxiety and Opioid Use Episode 1109 Fall 2022
Wearing special green eyeglasses for several hours a day reduces pain-related anxiety and may help decrease the need for opioids to manage severe pain in fibromyalgia patients and possibly others who experience chronic pain, according to a study being presented at the ANESTHESIOLOGY® 2022 annual meeting. #green #anxiety #fibromyalgia Effects Of Light Induced Analgesia On Anxiety For Fibromyalgia Patients Padma Gulur, M.D., Mary Wright, MS, Amanda Nelli, M.D. Duke University, Chapel Hill, North Carolina, United States A2094 October 23, 2022 American Society of Anesthesiologists https://www.medpagetoday.com/meetingcoverage/asa/101375 https://www.painnewsnetwork.org/s/A2094-Effects-Of-Light-Induced-Analgesia-On-Anxiety-For-Fibromyalgia-Patients.pdf Green light, green glasses, fibromyalgia, anxiety, fear, opioid, pain, pain reduction, pain relief, chronic pain, pain control, green
08:11
November 13, 2022
Green Glasses may reduce Fear based Anxiety and Opioid Use Episode 1109 Fall 2022
Green Glasses may reduce Fear based Anxiety and Opioid Use Episode 1109 Fall 2022
Green Glasses may reduce Fear based Anxiety and Opioid Use Wearing special green eyeglasses for several hours a day reduces pain-related anxiety and may help decrease the need for opioids to manage severe pain in fibromyalgia patients and possibly others who experience chronic pain, according to a study being presented at the ANESTHESIOLOGY® 2022 annual meeting. #green #anxiety #fibromyalgia Effects Of Light Induced Analgesia On Anxiety For Fibromyalgia Patients Padma Gulur, M.D., Mary Wright, MS, Amanda Nelli, M.D. Duke University, Chapel Hill, North Carolina, United States A2094 October 23, 2022 American Society of Anesthesiologists https://www.medpagetoday.com/meetingcoverage/asa/101375 https://www.painnewsnetwork.org/s/A2094-Effects-Of-Light-Induced-Analgesia-On-Anxiety-For-Fibromyalgia-Patients.pdf Green light, green glasses, fibromyalgia, anxiety, fear, opioid, pain, pain reduction, pain relief, chronic pain, pain control, green
08:11
November 13, 2022
AKG may increase exercise performance and muscle size Episode 1108 Fall 2022
AKG may increase exercise performance and muscle size Episode 1108 Fall 2022
AKG may increase exercise performance and muscle size Episode 1108 Fall 2022 Previous studies have shown that AKG plays biological functions such as regulating energy metabolism, promoting osteogenesis, improving immunity, and prolonging life span of animal organism #AKG #musclegrowth #muscleendurance Jinping Yang, Guli Xu, Yiming Xu, Pei Luo, Yexian Yuan, Lin Yao, Jingjing Zhou, Yunlong Zhu, Ishwari Gyawali, Chang Xu, Jinlong Feng, Zewei Ma, Yuxian Zeng, Songbo Wang, Ping Gao, Canjun Zhu, Qingyan Jiang, Gang Shu, AKG/OXGR1 promotes skeletal muscle blood flow and metabolism by relaxing vascular smooth muscle, Life Metabolism, 2022;, loac026, https://doi.org/10.1093/lifemeta/loac026 TCA, AKG, α-Ketoglutarate, alpha Ketoglutarate, muscle mass, metabolism, . Oxoglutarate receptor, muscle aging, OXGR1, type 1, exercise performance, endurance hypertrophy , tricarboxylic acid cycle, nerve regulation, hormone secretion, blood flow, fat deposition, slow oxidizing, angiogenesis, muscle growth, muscle size, vascular perfusion, skeletal muscle, krebs, citric
08:28
November 05, 2022
AKG may increase exercise performance and muscle size Episode 1108 Fall 2022
AKG may increase exercise performance and muscle size Episode 1108 Fall 2022
AKG may increase exercise performance and muscle size Episode 1108 Fall 2022 Previous studies have shown that AKG plays biological functions such as regulating energy metabolism, promoting osteogenesis, improving immunity, and prolonging life span of animal organism #AKG #musclegrowth #muscleendurance Jinping Yang, Guli Xu, Yiming Xu, Pei Luo, Yexian Yuan, Lin Yao, Jingjing Zhou, Yunlong Zhu, Ishwari Gyawali, Chang Xu, Jinlong Feng, Zewei Ma, Yuxian Zeng, Songbo Wang, Ping Gao, Canjun Zhu, Qingyan Jiang, Gang Shu, AKG/OXGR1 promotes skeletal muscle blood flow and metabolism by relaxing vascular smooth muscle, Life Metabolism, 2022;, loac026, https://doi.org/10.1093/lifemeta/loac026 TCA, AKG, α-Ketoglutarate, alpha Ketoglutarate, muscle mass, metabolism, . Oxoglutarate receptor, muscle aging, OXGR1, type 1, exercise performance, endurance hypertrophy , tricarboxylic acid cycle, nerve regulation, hormone secretion, blood flow, fat deposition, slow oxidizing, angiogenesis, muscle growth, muscle size, vascular perfusion, skeletal muscle, krebs, citric
08:28
November 05, 2022
Licorice Compounds and their Amazing Potential
Licorice Compounds and their Amazing Potential
Licorice Compounds and their Amazing Potential GL Glycyrrhizin and its derivative, glycyrrhetinic acid ( GA , exhibit a wide range of activities to elicit their oncoprotective and oncotherapeutic effects. The effects range from inducing cell cycle arrest, inducing apoptosis, inhibiting invasion and metastasis, immunomodulation, attenuating the inflammatory microenvironment in cancer to antioxidants, sensitizing the tumor to other drugs, and protecting from conventional therapy side effects #licorice #Glycyrrhizin #glycyrrhetinicacid Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam, Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights,Pharmacological Research,Volume 178,2022,106138,ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2022.106138. Licorice, Glycyrrhizin, glycyrrhetinic, anti inflammatory, metastasis, immunomodulation, oncoprotective,  oncotherapeutic, apoptosis, antioxidant, gza, gl, ga, Anti-estrogenic, chemotherapy,
09:16
October 31, 2022
Licorice Compounds and their Amazing Potential
Licorice Compounds and their Amazing Potential
Licorice Compounds and their Amazing Potential GL Glycyrrhizin and its derivative, glycyrrhetinic acid ( GA , exhibit a wide range of activities to elicit their oncoprotective and oncotherapeutic effects. The effects range from inducing cell cycle arrest, inducing apoptosis, inhibiting invasion and metastasis, immunomodulation, attenuating the inflammatory microenvironment in cancer to antioxidants, sensitizing the tumor to other drugs, and protecting from conventional therapy side effects #licorice #Glycyrrhizin #glycyrrhetinicacid Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam, Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights,Pharmacological Research,Volume 178,2022,106138,ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2022.106138. Licorice, Glycyrrhizin, glycyrrhetinic, anti inflammatory, metastasis, immunomodulation, oncoprotective,  oncotherapeutic, apoptosis, antioxidant, gza, gl, ga, Anti-estrogenic, chemotherapy,
09:16
October 31, 2022
Licorice Compounds and their Amazing Potential
Licorice Compounds and their Amazing Potential
Licorice Compounds and their Amazing Potential GL Glycyrrhizin and its derivative, glycyrrhetinic acid ( GA , exhibit a wide range of activities to elicit their oncoprotective and oncotherapeutic effects. The effects range from inducing cell cycle arrest, inducing apoptosis, inhibiting invasion and metastasis, immunomodulation, attenuating the inflammatory microenvironment in cancer to antioxidants, sensitizing the tumor to other drugs, and protecting from conventional therapy side effects #licorice #Glycyrrhizin #glycyrrhetinicacid Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam, Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights,Pharmacological Research,Volume 178,2022,106138,ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2022.106138. Licorice, Glycyrrhizin, glycyrrhetinic, anti inflammatory, metastasis, immunomodulation, oncoprotective,  oncotherapeutic, apoptosis, antioxidant, gza, gl, ga, Anti-estrogenic, chemotherapy,
09:16
October 30, 2022
Melatonin up to 30% higher with a weighted blanket. Episode 1106 Fall 2022
Melatonin up to 30% higher with a weighted blanket. Episode 1106 Fall 2022
"Using a weighted blanket increased melatonin concentrations in saliva by about 30 percent”   #melatonin #blanket #weightedblanket    Meth, E. M. S., Brandão, L. E. M., van Egmond, L. T., Xue, P., Grip, A., Wu, J., Adan, A., Andersson, F., Pacheco, A. P., Uvnäs-Moberg, K., Cedernaes, J., & Benedict, C. (2022). A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults. Journal of Sleep Research, e13743. https://doi.org/10.1111/jsr.13743
06:23
October 24, 2022
Melatonin up to 30% higher with a weighted blanket. Episode 1106 Fall 2022
Melatonin up to 30% higher with a weighted blanket. Episode 1106 Fall 2022
#melatonin #blanket #weightedblanket    Meth, E. M. S., Brandão, L. E. M., van Egmond, L. T., Xue, P., Grip, A., Wu, J., Adan, A., Andersson, F., Pacheco, A. P., Uvnäs-Moberg, K., Cedernaes, J., & Benedict, C. (2022). A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults. Journal of Sleep Research, e13743. https://doi.org/10.1111/jsr.13743
06:23
October 24, 2022
Melatonin up to 30% higher with a weighted blanket. Episode 1106 Fall 2022
Melatonin up to 30% higher with a weighted blanket. Episode 1106 Fall 2022
"Using a weighted blanket increased melatonin concentrations in saliva by about 30 percent”   #melatonin #blanket #weightedblanket    Meth, E. M. S., Brandão, L. E. M., van Egmond, L. T., Xue, P., Grip, A., Wu, J., Adan, A., Andersson, F., Pacheco, A. P., Uvnäs-Moberg, K., Cedernaes, J., & Benedict, C. (2022). A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults. Journal of Sleep Research, e13743. https://doi.org/10.1111/jsr.13743
06:23
October 24, 2022
Daikenchuto may protect the gut against inflammatory bowel disease
Daikenchuto may protect the gut against inflammatory bowel disease
Daikenchuto may protect the gut against inflammatory bowel disease Researchers report on the effects of a common herbal remedy on inflammatory bowel disease. A new study shows that DKT -- an herbal medicine containing ginger, pepper, ginseng, and maltose -- reduced the severity of colitis in lab mice by preventing the loss of important gut bacteria and by increasing levels of immune cells in the colon that fight inflammation. #Daikenchuto #colitis #ibd Zhengzheng Shi, Tadashi Takeuchi, Yumiko Nakanishi, Tamotsu Kato, Katharina Beck, Ritsu Nagata, Tomoko Kageyama, Ayumi Ito, Hiroshi Ohno, Naoko Satoh-Takayama. A Japanese Herbal Formula, Daikenchuto, Alleviates Experimental Colitis by Reshaping Microbial Profiles and Enhancing Group 3 Innate Lymphoid Cells. Frontiers in Immunology, 2022; 13 DOI: 10.3389/fimmu.2022.903459 Daikenchuto, inflammatory bowel disease, IBD. Colitis, gut, kampo, Lactobacillaceae, Lactobacillus, microbiome, DKT, ginger, pepper, ginseng, propionate, scfa, short-chain fatty acid
07:52
October 16, 2022
Daikenchuto may protect the gut against inflammatory bowel disease
Daikenchuto may protect the gut against inflammatory bowel disease
Daikenchuto may protect the gut against inflammatory bowel disease Researchers report on the effects of a common herbal remedy on inflammatory bowel disease. A new study shows that DKT -- an herbal medicine containing ginger, pepper, ginseng, and maltose -- reduced the severity of colitis in lab mice by preventing the loss of important gut bacteria and by increasing levels of immune cells in the colon that fight inflammation. #Daikenchuto #colitis #ibd Zhengzheng Shi, Tadashi Takeuchi, Yumiko Nakanishi, Tamotsu Kato, Katharina Beck, Ritsu Nagata, Tomoko Kageyama, Ayumi Ito, Hiroshi Ohno, Naoko Satoh-Takayama. A Japanese Herbal Formula, Daikenchuto, Alleviates Experimental Colitis by Reshaping Microbial Profiles and Enhancing Group 3 Innate Lymphoid Cells. Frontiers in Immunology, 2022; 13 DOI: 10.3389/fimmu.2022.903459 Daikenchuto, inflammatory bowel disease, IBD. Colitis, gut, kampo, Lactobacillaceae, Lactobacillus, microbiome, DKT, ginger, pepper, ginseng, propionate, scfa, short-chain fatty acid
07:52
October 16, 2022
Guar Gum may be a potent Immune regulator
Guar Gum may be a potent Immune regulator
Guar Gum may be a potent Immune regulator Diets high in guar gum, a common food additive and dietary fibre, limited inflammation and delayed the onset of multiple sclerosis (MS) symptoms in mice, according to new research by members of the University of British Columbia (UBC) Microbiology and Immunology department. #guargum #ms # neuroinflammation Fettig NM, Robinson HG, Allanach JR, Davis KM, Simister RL, Wang EJ, Sharon AJ, Ye J, Popple SJ, Seo JH, Gibson DL, Crowe SA, Horwitz MS, Osborne LC. Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis. Cell Rep. 2022 Sep 13;40(11):111328. doi: 10.1016/j.celrep.2022.111328. PMID: 36103823. Guar gum, fiber, fibre, autoimmune, neuroinflammation, th1, autoimmune encephalomyelitis, dietary fiber, microbiota, experimental autoimmune encephalomyelitis, EAE, multiple sclerosis, MS, CD4+ T cells
07:27
October 04, 2022
Guar Gum may be a potent Immune regulator
Guar Gum may be a potent Immune regulator
Guar Gum may be a potent Immune regulator Diets high in guar gum, a common food additive and dietary fibre, limited inflammation and delayed the onset of multiple sclerosis (MS) symptoms in mice, according to new research by members of the University of British Columbia (UBC) Microbiology and Immunology department. #guargum #ms # neuroinflammation Fettig NM, Robinson HG, Allanach JR, Davis KM, Simister RL, Wang EJ, Sharon AJ, Ye J, Popple SJ, Seo JH, Gibson DL, Crowe SA, Horwitz MS, Osborne LC. Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis. Cell Rep. 2022 Sep 13;40(11):111328. doi: 10.1016/j.celrep.2022.111328. PMID: 36103823. Guar gum, fiber, fibre, autoimmune, neuroinflammation, th1, autoimmune encephalomyelitis, dietary fiber, microbiota, experimental autoimmune encephalomyelitis, EAE, multiple sclerosis, MS, CD4+ T cells
07:27
October 04, 2022
Folic acid treatment associated with decreased risk of suicide attempts
Folic acid treatment associated with decreased risk of suicide attempts
Folic acid treatment associated with decreased risk of suicide attempts The study, published in JAMA Psychiatry on September 28th, used data from the health insurance claims of 866,586 patients and looked at the relationship between folic acid treatment and suicide attempts over a two-year period. They found that patients who filled prescriptions for folic acid, also known as vitamin B9, experienced a 44% reduction in suicidal events (suicide attempts and intentional self-harm). Robert Gibbons, PhD, the Blum-Riese Professor of Biostatistics and Medicine at the University of Chicago, the lead author of the study, is hopeful that these findings could improve suicide prevention efforts, especially because of how accessible folic acid is. “There are no real side effects, it doesn’t cost a lot of money, you can get it without a prescription,” Gibbons said. “This could potentially save tens of thousands of lives.” #mentalhealth #folicacid #B9 Gibbons RD, Hur K, Lavigne JE, Mann JJ. Association Between Folic Acid Prescription Fills and Suicide Attempts and Intentional Self-harm Among Privately Insured US Adults. JAMA Psychiatry. Published online September 28, 2022. doi:10.1001/jamapsychiatry.2022.2990 Self harm, folic acid, b9, folate, suicide attempts, psychiatry, suicide prevention, safe, suicide prevention efforts, save lives, mental health
10:11
October 02, 2022
Folic acid treatment associated with decreased risk of suicide attempts
Folic acid treatment associated with decreased risk of suicide attempts
Folic acid treatment associated with decreased risk of suicide attempts The study, published in JAMA Psychiatry on September 28th, used data from the health insurance claims of 866,586 patients and looked at the relationship between folic acid treatment and suicide attempts over a two-year period. They found that patients who filled prescriptions for folic acid, also known as vitamin B9, experienced a 44% reduction in suicidal events (suicide attempts and intentional self-harm). Robert Gibbons, PhD, the Blum-Riese Professor of Biostatistics and Medicine at the University of Chicago, the lead author of the study, is hopeful that these findings could improve suicide prevention efforts, especially because of how accessible folic acid is. “There are no real side effects, it doesn’t cost a lot of money, you can get it without a prescription,” Gibbons said. “This could potentially save tens of thousands of lives.” #mentalhealth #folicacid #B9 Gibbons RD, Hur K, Lavigne JE, Mann JJ. Association Between Folic Acid Prescription Fills and Suicide Attempts and Intentional Self-harm Among Privately Insured US Adults. JAMA Psychiatry. Published online September 28, 2022. doi:10.1001/jamapsychiatry.2022.2990 Self harm, folic acid, b9, folate, suicide attempts, psychiatry, suicide prevention, safe, suicide prevention efforts, save lives, mental health
10:11
October 02, 2022
Melatonin's Amazing Research Discoveries: Episode 1102 FALL 2022
Melatonin's Amazing Research Discoveries: Episode 1102 FALL 2022
Melatonin's Amazing Research Discoveries:  Episode 1102 FALL 2022 Like vitamin D, melatonin is found throughout the body. Melatonin has been found in many tissues other than the pineal gland and gut mucosa, including the brain, retina, lens, cochlea, trachea, skin, liver, kidney, thyroid, pancreas, thymus, spleen, and reproductive tissues. It is present in nearly all bodily fluids: #melatonin #antioxidant #chronobiotic Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients. 2022; 14(19):3934. https://doi.org/10.3390/nu14193934 Melatonin, vitamin d, chronobiotic, enterochromaffin, hormone, pineal, gut, darkness deficiency, plant derived, immune-active agent, mitochondrial regulator, migraine, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, lowering body temperature, sleep
11:45
September 26, 2022
Melatonin's Amazing Research Discoveries: Episode 1102 FALL 2022
Melatonin's Amazing Research Discoveries: Episode 1102 FALL 2022
Melatonin's Amazing Research Discoveries:  Episode 1102 FALL 2022 Like vitamin D, melatonin is found throughout the body. Melatonin has been found in many tissues other than the pineal gland and gut mucosa, including the brain, retina, lens, cochlea, trachea, skin, liver, kidney, thyroid, pancreas, thymus, spleen, and reproductive tissues. It is present in nearly all bodily fluids: #melatonin #antioxidant #chronobiotic Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients. 2022; 14(19):3934. https://doi.org/10.3390/nu14193934 Melatonin, vitamin d, chronobiotic, enterochromaffin, hormone, pineal, gut, darkness deficiency, plant derived, immune-active agent, mitochondrial regulator, migraine, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, lowering body temperature, sleep
11:45
September 26, 2022
Twice-daily nasal irrigation reduces COVID-related illness, death, study finds
Twice-daily nasal irrigation reduces COVID-related illness, death, study finds
"We found an 8.5-fold reduction in hospitalizations and no fatalities compared to our controls," says senior author Dr. Richard Schwartz, chair of the MCG Department of Emergency Medicine. "Both of those are pretty significant endpoints." #nasal #bakingsoda #iodine Amy L Baxter, Kyle R Schwartz, Ryan W Johnson, Ann-Marie Kuchinski, Kevin M Swartout, Arni S R Srinivasa Rao, Robert W Gibson, Erica Cherian, Taylor Giller, Houlton Boomer, Matthew Lyon, Richard Schwartz. Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients. Ear, Nose & Throat Journal, 2022; 014556132211237 DOI: 10.1177/01455613221123737 #bakingsoda #alkaline #iodine #nasalirrigation #coronavirus #saline Baking soda, alkaline, iodine, nasal irrigation, coronavirus, saline, spike protein, isotonic, sars, sodium bicarbonate, mucous membrane, furin, virus, povidone-iodine, salt
17:20
September 19, 2022
Twice-daily nasal irrigation reduces COVID-related illness, death, study finds
Twice-daily nasal irrigation reduces COVID-related illness, death, study finds
Twice-daily nasal irrigation reduces COVID-related illness, death, study finds "We found an 8.5-fold reduction in hospitalizations and no fatalities compared to our controls," says senior author Dr. Richard Schwartz, chair of the MCG Department of Emergency Medicine. "Both of those are pretty significant endpoints." #nasal #bakingsoda #iodine Amy L Baxter, Kyle R Schwartz, Ryan W Johnson, Ann-Marie Kuchinski, Kevin M Swartout, Arni S R Srinivasa Rao, Robert W Gibson, Erica Cherian, Taylor Giller, Houlton Boomer, Matthew Lyon, Richard Schwartz. Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients. Ear, Nose & Throat Journal, 2022; 014556132211237 DOI: 10.1177/01455613221123737 #bakingsoda #alkaline #iodine #nasalirrigation #coronavirus #saline Baking soda,  alkaline, iodine, nasal irrigation, coronavirus, saline, spike protein, isotonic, sars, sodium bicarbonate, mucous membrane, furin, virus, povidone-iodine, salt
17:20
September 19, 2022
Spirulina may be a powerful Memory Treatment [Episode 3300 Fall 2022]
Spirulina may be a powerful Memory Treatment [Episode 3300 Fall 2022]
Spirulina may be a powerful Memory Treatment The 12-week supplementation with SM70EE was shown to be valid and safe. Therefore, the significant findings of this study suggest that SM70EE supplementation in patients with MCI with memory disorders is safe and can play a role in the prevention and management of AD #spirulina #MCI #memory Choi W-Y, Lee W-K, Kim T-H, Ryu Y-K, Park A, Lee Y-J, Heo S-J, Oh C, Chung Y-C, Kang D-H. The Effects of Spirulina maxima Extract on Memory Improvement in Those with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2022; 14(18):3714. https://doi.org/10.3390/nu1418371 Microalgae, cyanobacterium, Spirulina, Spirulina maxima,  memory improvement, Alzheimer’s disease, functional food, mild cognitive impairment, MCI, visual learning, visual working memory #spirulina #MCI #memory #Microalgae #cyanobacterium #Alzheimers #food
10:44
September 12, 2022
Spirulina may be a powerful Memory Treatment
Spirulina may be a powerful Memory Treatment
Spirulina may be a powerful Memory Treatment The 12-week supplementation with SM70EE was shown to be valid and safe. Therefore, the significant findings of this study suggest that SM70EE supplementation in patients with MCI with memory disorders is safe and can play a role in the prevention and management of AD #spirulina #MCI #memory Choi W-Y, Lee W-K, Kim T-H, Ryu Y-K, Park A, Lee Y-J, Heo S-J, Oh C, Chung Y-C, Kang D-H. The Effects of Spirulina maxima Extract on Memory Improvement in Those with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2022; 14(18):3714. https://doi.org/10.3390/nu1418371 Microalgae, cyanobacterium, Spirulina, Spirulina maxima,  memory improvement, Alzheimer’s disease, functional food, mild cognitive impairment, MCI, visual learning, visual working memory #spirulina #MCI #memory #Microalgae #cyanobacterium #Alzheimers #food
10:44
September 12, 2022
Lupus, Memory Loss and Cancer Breakthroughs
Lupus, Memory Loss and Cancer Breakthroughs
Lupus, Memory Loss and Cancer Breakthroughs Lupus pill shows promise in mice; clinical trial underway https://www.eurekalert.org/news-releases/960980#.YwejKjE4TUo.wordpress “scientists report they have begun phase 2 clinical trials with a pill containing a compound that, in mice, not only prevents lupus-like symptoms, but also reverses signs of organ damage caused by the disease and prevents death.” Can we reverse the effects of age related memory loss? Experts say yes https://www.eurekalert.org/news-releases/963187 “and found that electrical brain stimulation for 20 minutes on four consecutive days can improve working memory and long-term memory in individuals 65 years and older for at least one month” Cancer study: Major preventive effect from resistant starch in people with Lynch syndrome https://www.sciencedaily.com/releases/2022/07/220725203606.htm "We found that resistant starch reduces a range of cancers by over 60%.” #lupus #cancer #memory Lupus, afimetoran, organ damage, working memory, long term memory, electrodes, electrical stimulation, novelose, resistant starch, cancer, cancer prevention, lynch syndrome, oesophageal, gastric, biliary tract, pancreatic, duodenum cancers.
14:34
September 05, 2022
Lupus, Memory Loss and Cancer Breakthroughs
Lupus, Memory Loss and Cancer Breakthroughs
Lupus, Memory Loss and Cancer Breakthroughs Lupus pill shows promise in mice; clinical trial underway https://www.eurekalert.org/news-releases/960980#.YwejKjE4TUo.wordpress “scientists report they have begun phase 2 clinical trials with a pill containing a compound that, in mice, not only prevents lupus-like symptoms, but also reverses signs of organ damage caused by the disease and prevents death.” Can we reverse the effects of age related memory loss? Experts say yes https://www.eurekalert.org/news-releases/963187 “and found that electrical brain stimulation for 20 minutes on four consecutive days can improve working memory and long-term memory in individuals 65 years and older for at least one month” Cancer study: Major preventive effect from resistant starch in people with Lynch syndrome https://www.sciencedaily.com/releases/2022/07/220725203606.htm "We found that resistant starch reduces a range of cancers by over 60%.” #lupus #cancer #memory Lupus, afimetoran, organ damage, working memory, long term memory, electrodes, electrical stimulation, novelose, resistant starch, cancer, cancer prevention, lynch syndrome, oesophageal, gastric, biliary tract, pancreatic, duodenum cancers.
14:34
September 05, 2022
Grapes Have Astonishing Potential for Health and Longevity
Grapes Have Astonishing Potential for Health and Longevity
Grapes Have Astonishing Potential for Health and Longevity Adding grapes to a high-fat diet also increased levels of antioxidant genes and delayed natural death. Acknowledging that it is not an exact science to translate years of lifespan from a mouse to a human, Pezzuto said that his best estimate is the change observed in the study would correspond to an additional 4-5 years in the life of a human. #grapes #longevity #NAFLD Dave A, Park E-J, Kumar A, Parande F, Beyoğlu D, Idle JR, Pezzuto JM. Consumption of Grapes Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity in Female C57BL/6J Mice Provided with a High-Fat Western-Pattern Diet. Foods. 2022; 11(13):1984. https://doi.org/10.3390/foods11131984 Grapes, metabolic diseases, high-fat diet, RNA sequencing, nutrigenomics, nafld, life extension, life expectancy, glutathione, California table grapes, health, gene expression. Microbiome, hepatic oxidative stress, glucose uptake, liver health, energy metabolism #grapes #longevity #NAFLD #gene #microbiome #longevity #liver #glucose #energy #health
13:56
August 29, 2022
Grapes Have Astonishing Potential for Health and Longevity
Grapes Have Astonishing Potential for Health and Longevity
Grapes Have Astonishing Potential for Health and Longevity Adding grapes to a high-fat diet also increased levels of antioxidant genes and delayed natural death. Acknowledging that it is not an exact science to translate years of lifespan from a mouse to a human, Pezzuto said that his best estimate is the change observed in the study would correspond to an additional 4-5 years in the life of a human. #grapes #longevity #NAFLD Dave A, Park E-J, Kumar A, Parande F, Beyoğlu D, Idle JR, Pezzuto JM. Consumption of Grapes Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity in Female C57BL/6J Mice Provided with a High-Fat Western-Pattern Diet. Foods. 2022; 11(13):1984. https://doi.org/10.3390/foods11131984 Grapes, metabolic diseases, high-fat diet, RNA sequencing, nutrigenomics, nafld, life extension, life expectancy, glutathione, California table grapes, health, gene expression. Microbiome, hepatic oxidative stress, glucose uptake, liver health, energy metabolism #grapes #longevity #NAFLD #gene #microbiome #longevity #liver #glucose #energy #health
13:56
August 29, 2022
GlyNAC may reverse multiple hallmarks of aging
GlyNAC may reverse multiple hallmarks of aging
GlyNAC may reverse multiple hallmarks of aging “This is the first randomized clinical trial of GlyNAC supplementation in older humans (*March 2021 was smaller and open label), and it found that a wide variety of age-associated abnormalities improved in older adults supplemented with GlyNAC, while no improvements were seen in those receiving placebo,” said corresponding author Dr. Rajagopal Sekhar, professor of medicine - endocrinology, diabetes and metabolism at Baylor. Premranjan Kumar, PhD, Chun Liu, BS, James Suliburk, MD, Jean W Hsu, PhD, Raja Muthupillai, PhD, Farook Jahoor, PhD, Charles G Minard, PhD, George E Taffet, MD, Rajagopal V Sekhar, MD, Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial, The Journals of Gerontology: Series A, 2022;, glac135, https://doi.org/10.1093/gerona/glac135 #GlyNAC #longevity #glutathione GlyNAC, NAC, glycine, glutathione, N-Acetylcysteine, aging, longevity, n acetyl cysteine, celltrient, mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue, cellular senescence, glutathione deficiency, gait, gait speed, Oxidative Stress, Physical Function #GlyNAC #longevity#glutathione #nac #nacetylcysteine #aging #muscle #glycine
16:21
August 22, 2022
GlyNAC may reverse multiple hallmarks of aging
GlyNAC may reverse multiple hallmarks of aging
GlyNAC may reverse multiple hallmarks of aging “This is the first randomized clinical trial of GlyNAC supplementation in older humans (*March 2021 was smaller and open label), and it found that a wide variety of age-associated abnormalities improved in older adults supplemented with GlyNAC, while no improvements were seen in those receiving placebo,” said corresponding author Dr. Rajagopal Sekhar, professor of medicine - endocrinology, diabetes and metabolism at Baylor. Premranjan Kumar, PhD, Chun Liu, BS, James Suliburk, MD, Jean W Hsu, PhD, Raja Muthupillai, PhD, Farook Jahoor, PhD, Charles G Minard, PhD, George E Taffet, MD, Rajagopal V Sekhar, MD, Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial, The Journals of Gerontology: Series A, 2022;, glac135, https://doi.org/10.1093/gerona/glac135 #GlyNAC #longevity #glutathione GlyNAC, NAC, glycine, glutathione, N-Acetylcysteine, aging, longevity, n acetyl cysteine, celltrient, mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue, cellular senescence, glutathione deficiency, gait, gait speed, Oxidative Stress, Physical Function #GlyNAC #longevity#glutathione #nac #nacetylcysteine #aging #muscle #glycine
16:21
August 22, 2022
B vitamins can potentially be used to treat advanced NAFLD
B vitamins can potentially be used to treat advanced NAFLD
B vitamins can potentially be used to treat advanced NAFLD "Our findings are both exciting and important because they suggest that a relatively inexpensive therapy, vitamin B12 and folic acid, could be used to prevent and/or delay the progression of NASH," said Dr Singh. "Additionally, serum and hepatic homocysteine levels could serve as a biomarker for NASH severity." Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen. Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing Syntaxin 17 homocysteinylation. Journal of Hepatology, 2022; DOI: 10.1016/j.jhep.2022.06.033 #B12 #NAFLD #NASH Homocysteine,Vitamin therapy,Syntaxin-17,Autophagy,Protein homocysteinylation,Non-alcoholic steatohepatitis (NASH),Fibrosis,B12,Folate. Folic acid, fatty liver, nafld, liver disease
10:30
August 15, 2022
B vitamins can potentially be used to treat advanced NAFLD
B vitamins can potentially be used to treat advanced NAFLD
B vitamins can potentially be used to treat advanced NAFLD "Our findings are both exciting and important because they suggest that a relatively inexpensive therapy, vitamin B12 and folic acid, could be used to prevent and/or delay the progression of NASH," said Dr Singh. "Additionally, serum and hepatic homocysteine levels could serve as a biomarker for NASH severity." Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen. Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing Syntaxin 17 homocysteinylation. Journal of Hepatology, 2022; DOI: 10.1016/j.jhep.2022.06.033 #B12 #NAFLD #NASH Homocysteine,Vitamin therapy,Syntaxin-17,Autophagy,Protein homocysteinylation,Non-alcoholic steatohepatitis (NASH),Fibrosis,B12,Folate. Folic acid, fatty liver, nafld, liver disease
10:30
August 15, 2022
Leaky Gut and Blood Glucose Quickly Improved with Green Tea
Leaky Gut and Blood Glucose Quickly Improved with Green Tea
Leaky Gut and Blood Glucose Quickly Improved with Green Tea “We did not attempt to cure metabolic syndrome with a one-month study,” he said. “But based on what we know about the causal factors behind metabolic syndrome, there is potential for green tea to be acting at least in part at the gut level to alleviate the risk for either developing it or reversing it if you already have metabolic syndrome.” #greentea #metabolicsyndrome #leakygut Joanna Hodges, Min Zeng, Sisi Cao, Avinash Pokala, Shahabbedin Rezaei, Geoffrey Sasaki, Yael Vodovotz, Richard Bruno, Catechin-Rich Green Tea Extract Reduced Intestinal Inflammation and Fasting Glucose in Metabolic Syndrome and Healthy Adults: A Randomized, Controlled, Crossover Trial, Current Developments in Nutrition, Volume 6, Issue Supplement_1, June 2022, Page 981, https://doi.org/10.1093/cdn/nzac068.010 Green Tea Extract, Green tea, GTE, Leaky Gut, Blood Sugars, Blood Glucose , Mets, gut inflammation, intestinal inflammation, cardiometabolic disorders, catechins, Gut permeability, diabetes, insulin sensitivity, #greentea #metabolicsyndrome #leakygut #gte #mets #catechins #gte
10:28
August 02, 2022
Leaky Gut and Blood Glucose Quickly Improved with Green Tea
Leaky Gut and Blood Glucose Quickly Improved with Green Tea
Leaky Gut and Blood Glucose Quickly Improved with Green Tea “We did not attempt to cure metabolic syndrome with a one-month study,” he said. “But based on what we know about the causal factors behind metabolic syndrome, there is potential for green tea to be acting at least in part at the gut level to alleviate the risk for either developing it or reversing it if you already have metabolic syndrome.” #greentea #metabolicsyndrome #leakygut Joanna Hodges, Min Zeng, Sisi Cao, Avinash Pokala, Shahabbedin Rezaei, Geoffrey Sasaki, Yael Vodovotz, Richard Bruno, Catechin-Rich Green Tea Extract Reduced Intestinal Inflammation and Fasting Glucose in Metabolic Syndrome and Healthy Adults: A Randomized, Controlled, Crossover Trial, Current Developments in Nutrition, Volume 6, Issue Supplement_1, June 2022, Page 981, https://doi.org/10.1093/cdn/nzac068.010 Green Tea Extract, Green tea, GTE, Leaky Gut, Blood Sugars, Blood Glucose , Mets, gut inflammation, intestinal inflammation, cardiometabolic disorders, catechins, Gut permeability, diabetes, insulin sensitivity, #greentea #metabolicsyndrome #leakygut #gte #mets #catechins #gte
10:28
August 02, 2022
Taurine may be an Anti-Aging powerhouse via Superoxide Dismutase
Taurine may be an Anti-Aging powerhouse via Superoxide Dismutase
Markers of oxidative stress were analyzed in blood samples collected before and at the end of the intervention. One of the most interesting results was an increase of almost 20% in levels of the antioxidant enzyme superoxide dismutase (SOD) in the group that received taurine, compared with a decrease of 3.5% in the control group. As the authors explain, SOD protects cells against harmful reactions of the superoxide radical. Abud GF, De Carvalho FG, Batitucci G, Travieso SG, Bueno Junior CR, Barbosa Junior F, Marchini JS, de Freitas EC. Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70. Nutrition. 2022 Sep;101:111706. doi: 10.1016/j.nut.2022.111706. Epub 2022 Apr 22. PMID: 35700594. #taurine #antiaging #SOD Taurine, sod, superoxide dismutase, free radicals, youth, aging, anti aging, malondialdehyde, lipid peroxidation, antioxidant, antiaging therapy, enzyme
09:47
July 26, 2022
Taurine may be an Anti-Aging powerhouse via Superoxide Dismutase
Taurine may be an Anti-Aging powerhouse via Superoxide Dismutase
Markers of oxidative stress were analyzed in blood samples collected before and at the end of the intervention. One of the most interesting results was an increase of almost 20% in levels of the antioxidant enzyme superoxide dismutase (SOD) in the group that received taurine, compared with a decrease of 3.5% in the control group. As the authors explain, SOD protects cells against harmful reactions of the superoxide radical. Abud GF, De Carvalho FG, Batitucci G, Travieso SG, Bueno Junior CR, Barbosa Junior F, Marchini JS, de Freitas EC. Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70. Nutrition. 2022 Sep;101:111706. doi: 10.1016/j.nut.2022.111706. Epub 2022 Apr 22. PMID: 35700594. #taurine #antiaging #SOD Taurine, sod, superoxide dismutase, free radicals, youth, aging, anti aging, malondialdehyde, lipid peroxidation, antioxidant, antiaging therapy, enzyme
09:47
July 26, 2022
High Fat Diet Completely Suppressed by Acidic Activated Charcoal
High Fat Diet Completely Suppressed by Acidic Activated Charcoal
Acidic activated charcoal improved HFD-induced obesity and insulin resistance without any serious adverse effects. These beneficial effects were likely due to modulating lipid absorption and altered FA/BA metabolism. Zhang X, Diao P, Yokoyama H, Inoue Y, Tanabe K, Wang X, Hayashi C, Yokoyama T, Zhang Z, Hu X, Nakajima T, Kimura T, Nakayama J, Nakamuta M, Tanaka N. Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice. Front Nutr. 2022 May 12;9:852767. doi: 10.3389/fnut.2022.852767. PMID: 35634388; PMCID: PMC9134190. #charcoal #diet #metabolism Acidic activated charcoal, red pine, High fat diet, Ultra processed foods, adipose microinflammation, lipid absorption, Akamatsu tree, bile acids, insulin resistance, metabolism, body weight
10:17
July 19, 2022
High Fat Diet Completely Suppressed by Acidic Activated Charcoal
High Fat Diet Completely Suppressed by Acidic Activated Charcoal
High Fat Diet Completely Suppressed by Acidic Activated Charcoal Acidic activated charcoal improved HFD-induced obesity and insulin resistance without any serious adverse effects. These beneficial effects were likely due to modulating lipid absorption and altered FA/BA metabolism. Zhang X, Diao P, Yokoyama H, Inoue Y, Tanabe K, Wang X, Hayashi C, Yokoyama T, Zhang Z, Hu X, Nakajima T, Kimura T, Nakayama J, Nakamuta M, Tanaka N. Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice. Front Nutr. 2022 May 12;9:852767. doi: 10.3389/fnut.2022.852767. PMID: 35634388; PMCID: PMC9134190. #charcoal #diet #metabolism Acidic activated charcoal, red pine, High fat diet, Ultra processed foods, adipose microinflammation, lipid absorption, Akamatsu tree, bile acids, insulin resistance, metabolism, body weight
10:17
July 19, 2022
Wound Healing Accelerated with Topical DIM
Wound Healing Accelerated with Topical DIM
Wound Healing Accelerated with Topical DIM The phytochemical 3,3'-diindolylmethane (DIM) successfully broke down the biofilms protecting two different pathogens including Acinetobacter baumannii and pseudomonas aeruginosa– enabling their eradication 65% and 70% of the time, respectively. Combined with antibiotics, that number jumped to 94%. Golberg K, Markus V, Kagan B-e, Barzanizan S, Yaniv K, Teralı K, Kramarsky-Winter E, Marks RS, Kushmaro A. Anti-Virulence Activity of 3,3′-Diindolylmethane (DIM): A Bioactive Cruciferous Phytochemical with Accelerated Wound Healing Benefits. Pharmaceutics. 2022; 14(5):967. https://doi.org/10.3390/pharmaceutics14050967 #DIM #wounds #healing #ulcers DIM, Wounds, Healing, ULCERS, BIOFILM, P. aeruginosa , Pseudomonas aeruginosa, Gram-negative pathogens, Phytochemicals, Antimicrobial , Acinetobacter baumannii, hospital infections, battlefield infections, A. baumannii, Diindolylmethane, acne, candida
07:34
July 12, 2022
Wound Healing Accelerated with Topical DIM
Wound Healing Accelerated with Topical DIM
Wound Healing Accelerated with Topical DIM The phytochemical 3,3'-diindolylmethane (DIM) successfully broke down the biofilms protecting two different pathogens including Acinetobacter baumannii and pseudomonas aeruginosa– enabling their eradication 65% and 70% of the time, respectively. Combined with antibiotics, that number jumped to 94%. Golberg K, Markus V, Kagan B-e, Barzanizan S, Yaniv K, Teralı K, Kramarsky-Winter E, Marks RS, Kushmaro A. Anti-Virulence Activity of 3,3′-Diindolylmethane (DIM): A Bioactive Cruciferous Phytochemical with Accelerated Wound Healing Benefits. Pharmaceutics. 2022; 14(5):967. https://doi.org/10.3390/pharmaceutics14050967 #DIM #wounds #healing #ulcers DIM, Wounds, Healing, ULCERS, BIOFILM, P. aeruginosa , Pseudomonas aeruginosa, Gram-negative pathogens, Phytochemicals, Antimicrobial , Acinetobacter baumannii, hospital infections, battlefield infections, A. baumannii, Diindolylmethane, acne, candida DIM, Wounds, Healing, ULCERS, BIOFILM, P. aeruginosa , Pseudomonas aeruginosa, Gram-negative pathogens, Phytochemicals, Antimicrobial , Acinetobacter baumannii, hospital infections, battlefield infections, A. baumannii, Diindolylmethane, acne, candida
07:33
July 12, 2022
Muscle Fatigue Improved with Urolithin A
Muscle Fatigue Improved with Urolithin A
Muscle Fatigue Improved with Urolithin A these results are still exciting because they demonstrate that just taking a supplement for a short duration actually improved muscle endurance. Fatigue resistance got better in the absence of exercise." Sophia Liu, Davide D’Amico, Eric Shankland, Saakshi Bhayana, Jose M. Garcia, Patrick Aebischer, Chris Rinsch, Anurag Singh, David J. Marcinek. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults. JAMA Network Open, 2022; 5 (1): e2144279 DOI: 10.1001/jamanetworkopen.2021.44279 #urolithinA #endurance #fatigue Urolithin A, Fatigue, Muscle, CRP, Mitochondrial, acylcarnitines, maximum voluntary contraction, mitophagy, elderly, weakness, endurance,
08:27
July 04, 2022
Muscle Fatigue Improved with Urolithin A
Muscle Fatigue Improved with Urolithin A
Muscle Fatigue Improved with Urolithin A these results are still exciting because they demonstrate that just taking a supplement for a short duration actually improved muscle endurance. Fatigue resistance got better in the absence of exercise." Sophia Liu, Davide D’Amico, Eric Shankland, Saakshi Bhayana, Jose M. Garcia, Patrick Aebischer, Chris Rinsch, Anurag Singh, David J. Marcinek. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults. JAMA Network Open, 2022; 5 (1): e2144279 DOI: 10.1001/jamanetworkopen.2021.44279 #urolithinA #endurance #fatigue Urolithin A, Fatigue, Muscle, CRP, Mitochondrial, acylcarnitines, maximum voluntary contraction, mitophagy, elderly, weakness, endurance,
08:27
July 04, 2022
AHCC shows promise in clearing HPV
AHCC shows promise in clearing HPV
AHCC shows promise in clearing HPV Patients in the placebo group received a placebo for 12 months. The study found that 14 of 22 patients (63.6%) in the treatment arm became HPV-negative AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections Front. Oncol., 22 June 2022 | https://doi.org/10.3389/fonc.2022.881902 https://www.eurekalert.org/news-releases/956667#.YrUfbtgh65k.wordpress #HPV #AHCC #HumanPapillomavirus #HPV #AHCC #HumanPapillomavirus #lentinula #ifn #igg1 #nk #infection #mushroom #immune human papillomavirus, HPV, AHCC, NEGATIVE, active hexose correlated compound, lentinula edodes mycelia, MUSHROOM, INFECTION, IMMUNE, ONCOLOGY, interferon alpha, interferon beta, IFN, interferon gamma, IFN, IgG1, T lymphocytes, natural killer cell levels, NK
10:29
June 27, 2022
AHCC shows promise in clearing HPV
AHCC shows promise in clearing HPV
AHCC shows promise in clearing HPV Patients in the placebo group received a placebo for 12 months. The study found that 14 of 22 patients (63.6%) in the treatment arm became HPV-negative AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections Front. Oncol., 22 June 2022 | https://doi.org/10.3389/fonc.2022.881902 https://www.eurekalert.org/news-releases/956667#.YrUfbtgh65k.wordpress #HPV #AHCC #HumanPapillomavirus #HPV #AHCC #HumanPapillomavirus #lentinula #ifn #igg1 #nk #infection #mushroom #immune human papillomavirus, HPV, AHCC, NEGATIVE, active hexose correlated compound, lentinula edodes mycelia, MUSHROOM, INFECTION, IMMUNE, ONCOLOGY, interferon alpha, interferon beta, IFN, interferon gamma, IFN, IgG1, T lymphocytes, natural killer cell levels, NK
10:29
June 27, 2022
Discoveries in Depression Autism Liver Aging and Athletic Performance
Discoveries in Depression Autism Liver Aging and Athletic Performance
Discoveries in Depression Autism Liver Aging and Athletic Performance Your liver is just under three years old An international team of scientists used retrospective radiocarbon birth dating to show that the human liver stays young throughout life and is on average less than three years old. https://www.cell.com/cell-systems/fulltext/S2405-4712(22)00171-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405471222001715%3Fshowall%3Dtrue Drumming improves behaviour and brain function in autistic adolescents, scientists reveal Drumming for 90 minutes each week helps autistic children overcome hyperactivity and attention deficit difficulties https://www.pnas.org/doi/10.1073/pnas.2106244119 Good bacteria to tackle depression Intestinal flora plays an important role in health – including mental health. Researchers from the University of Basel and the University Psychiatric Clinics Basel (UPK) have shown that probiotics can support the effect of antidepressants and help to alleviate depression. Antibiotics wreak havoc on athletic performance -Knocking out gut bacteria deflates the will, ability to exercise New research demonstrates that by killing essential gut bacteria, antibiotics ravage athletes' motivation and endurance. The UC Riverside-led mouse study suggests the microbiome is a big factor separating athletes from couch potatoes. https://www.sciencedirect.com/science/article/pii/S0376635722000675?via%3Dihub #probiotocs #depression #endurance Probiotics, autism, music, grey matter, gray matter, motivation, autism autistic, depression, mood, bacteria, microbiome, liver age, cell renewal, cell age, c14, carbon dating, drumming, drums, antibiotics, energy, fuel, glucose, gut brain axis, muscle #probiotocs #depression #endurance #exercise #microbiome #aging #cell #autism #mood #gutbrain #energy #bacteria #impulse
12:57
June 24, 2022
Discoveries in Depression Autism Liver Aging and Athletic Performance
Discoveries in Depression Autism Liver Aging and Athletic Performance
Discoveries in Depression Autism Liver Aging and Athletic Performance Your liver is just under three years old An international team of scientists used retrospective radiocarbon birth dating to show that the human liver stays young throughout life and is on average less than three years old. https://www.cell.com/cell-systems/fulltext/S2405-4712(22)00171-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405471222001715%3Fshowall%3Dtrue Drumming improves behaviour and brain function in autistic adolescents, scientists reveal Drumming for 90 minutes each week helps autistic children overcome hyperactivity and attention deficit difficulties https://www.pnas.org/doi/10.1073/pnas.2106244119 Good bacteria to tackle depression Intestinal flora plays an important role in health – including mental health. Researchers from the University of Basel and the University Psychiatric Clinics Basel (UPK) have shown that probiotics can support the effect of antidepressants and help to alleviate depression. Antibiotics wreak havoc on athletic performance -Knocking out gut bacteria deflates the will, ability to exercise New research demonstrates that by killing essential gut bacteria, antibiotics ravage athletes' motivation and endurance. The UC Riverside-led mouse study suggests the microbiome is a big factor separating athletes from couch potatoes. https://www.sciencedirect.com/science/article/pii/S0376635722000675?via%3Dihub #probiotocs #depression #endurance Probiotics, autism, music, grey matter, gray matter, motivation, autism autistic, depression, mood, bacteria, microbiome, liver age, cell renewal, cell age, c14, carbon dating, drumming, drums, antibiotics, energy, fuel, glucose, gut brain axis, muscle #probiotocs #depression #endurance #exercise #microbiome #aging #cell #autism #mood #gutbrain #energy #bacteria #impulse
12:57
June 23, 2022
Breakthroughs in DHA ZINC INULIN & D
Breakthroughs in DHA ZINC INULIN & D
Breakthroughs in DHA ZINC INULIN & D Study shows people with a high omega-3 DHA level in their blood are at 49% lower risk of Alzheimer’s https://www.mdpi.com/2072-6643/14/12/2408/htm Zinc found to play an important role in lung fibrosis https://www.jci.org/articles/view/157338 Dietary fibre in the gut may help with skin allergies: Monash study https://www.nature.com/articles/s41385-022-00524-9 Vitamin D may restore the body’s natural barrier against ovarian cancer https://www.sciencedirect.com/science/article/pii/S0945053X22000397?via%3Dihub #alzheimers #IPF #Ovarian Alzheimer’s , Dementia, Memory, DHA, Fibrosis, IPF, idiopathic pulmonary fibrosis, zinc, zip8, lungs, Docosahexaenoic acid, omega, inulin, skin barrier, dust mites, butyrate, SCFA, Fiber, Vitamin D, Ovarian Cancer, allergic skin inflammation, skin barrier, fermentable, mesothelial cells, zinc transporter 8, peritoneal #alzheimers #IPF #Ovarian #DHA #fibrosis #zinc #inulin #VitaminD #zip8 #omega #cancer #skin #scfa #fiber #fibre #ovarian #allergies #lungs
15:05
June 14, 2022
Breakthroughs in DHA ZINC INULIN & D
Breakthroughs in DHA ZINC INULIN & D
Study shows people with a high omega-3 DHA level in their blood are at 49% lower risk of Alzheimer’s https://www.mdpi.com/2072-6643/14/12/2408/htm Zinc found to play an important role in lung fibrosis https://www.jci.org/articles/view/157338 Dietary fibre in the gut may help with skin allergies: Monash study https://www.nature.com/articles/s41385-022-00524-9 Vitamin D may restore the body’s natural barrier against ovarian cancer https://www.sciencedirect.com/science/article/pii/S0945053X22000397?via%3Dihub #alzheimers #IPF #Ovarian Alzheimer’s , Dementia, Memory, DHA, Fibrosis, IPF, idiopathic pulmonary fibrosis, zinc, zip8, lungs, Docosahexaenoic acid, omega, inulin, skin barrier, dust mites, butyrate, SCFA, Fiber, Vitamin D, Ovarian Cancer, allergic skin inflammation, skin barrier, fermentable, mesothelial cells, zinc transporter 8, peritoneal #alzheimers #IPF #Ovarian #DHA #fibrosis #zinc #inulin #VitaminD #zip8 #omega #cancer #skin #scfa #fiber #fibre #ovarian #allergies #lungs
15:05
June 14, 2022
Opioid use cut in Half with essential oils post-surgery
Opioid use cut in Half with essential oils post-surgery
Opioid use cut in Half with essential oils post-surgery The researchers concluded: “Our results suggest that, by controlling anxiety, aromatherapy can help control pain and reduce opioid consumption. This is important, given the established role of the use of opioids in surgical patients in the overall opioid crisis in the US.” #opioid #aromatherapy #pain Abstract 08AP02-05 at Euroanaesthesia, the annual meeting of the European Society of Anaesthesiology and Intensive Care (ESAIC) Opioid, aromatherapy, peppermint, lavender, anxiety, surgery, pain killers, limbic system, pain reduction, anxious, calming, relaxing, therapy, essential oils, addiction, opiates #opioid #aromatherapy #pain #peppermint #lavender #pain #anxiety #essentialoils #opiates #addiction #relaxation
08:41
June 06, 2022
How cranberries could improve memory and ward off dementia
How cranberries could improve memory and ward off dementia
How cranberries could improve memory and ward off dementia Researchers have found that eating cranberries could improve memory, ward off dementia, and reduce 'bad' cholesterol. The research team studied the benefits of consuming the equivalent of a cup of cranberries a day among 50 to 80-year-olds. They hope that their findings could have implications for the prevention of neurodegenerative diseases such as dementia. #cranberries #memory #dementia Emma Flanagan, Donnie Cameron, Rashed Sobhan, Chloe Wong, Matthew G. Pontifex, Nicole Tosi, Pedro Mena, Daniele Del Rio, Saber Sami, Arjan Narbad, Michael Müller, Michael Hornberger, David Vauzour. Chronic Consumption of Cranberries (Vaccinium macrocarpon) for 12 Weeks Improves Episodic Memory and Regional Brain Perfusion in Healthy Older Adults: A Randomised, Placebo-Controlled, Parallel-Groups Feasibility Study. Frontiers in Nutrition, 2022; 9 DOI: 10.3389/fnut.2022.849902 Cranberry, cranberries, polyphenols, memory, recall, dementia, ldl, nucleus accumbens, medial temporal, prefrontal, episodic memory, visual episodic memory, ), neural functioning, brain perfusion, oxygen, glucose, brain energy, Vaccinium macrocarpon #cranberries #memory #dementia #recall #polyphenol #perfusion #accumbens #episodic #temporal #Vacciniummacrocarpon #ldl
06:45
May 31, 2022
Herbs for Tendons / Carpal Tunnel Syndrome
Herbs for Tendons / Carpal Tunnel Syndrome
Herbs for Tendons / Carpal Tunnel Syndrome This review discusses the utility of herbal nutraceuticals that have demonstrated safety and tolerability as anti-inflammatory agents for the prevention and treatment of tendinitis through the suppression of catabolic signaling pathways Mueller A-L, Brockmueller A, Kunnumakkara AB, Shakibaei M. Modulation of Inflammation by Plant-Derived Nutraceuticals in Tendinitis. Nutrients. 2022; 14(10):2030. https://doi.org/10.3390/nu14102030 Carpal tunnel syndrome, tendonitis, herb, phytochemicals, phytopharmaceuticals, inflammation, anti-inflammatory, echinacea, icariin, Epimedium grandiflorum, flavonoids, bromelain, curcumin, quercetin, egcg, green tea, genistein, avocado, resveratrol, polyphenols Achilles, rotator cuff, Boswellia serrata, tendinopathy, epicondylitis #tendons #tendonitis #herbs #carpal #phytochemicals #phytopharmaceuticals #inflammation  #echinacea #icariin #Epimedium #flavonoids, #bromelain, #curcumin, #quercetin, #egcg #greentea, #genistein, #avocado, #resveratrol, #polyphenols  #Boswellia #epicondylitis
13:09
May 16, 2022
Circadian Caloric Reduction Increased Life Expectancy up to 35%
Circadian Caloric Reduction Increased Life Expectancy up to 35%
Circadian Caloric Reduction Increased Life Expectancy up to 35% Victoria Acosta-Rodríguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Mary Wight-Carter, Carla B. Green, Joseph S. Takahashi. Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science, 2022; DOI: 10.1126/science.abk0297 #longevity #calories #circadian Diet, fasting, circadian, longevity, lifespan, calorie restriction, life extension, internal clock, Effects of Reducing Intake of Energy, CALERIE, Circadian alignment, aging, gene expression #longevity #calories #circadian #fasting #aging #calories #activity #lifespan #timing
09:45
May 09, 2022
MCT 8C may be a lifesaver for heart troubles
MCT 8C may be a lifesaver for heart troubles
These results indicated that 8C significantly improved cardiac function by approximately 40%.   Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z. Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation. Elife. 2021 Dec 23;10:e60311. doi: 10.7554/eLife.60311. PMID: 34939931; PMCID: PMC8763402.   #heart #mct #heartattack
10:47
May 03, 2022
Kudzu Roots and Soy Molasses may help treat three types of cancer
Kudzu Roots and Soy Molasses may help treat three types of cancer
Isoflavones found in plants are effective against dense tumor structures affecting human internal organs. For example, soy extract is most effective against metastases and malignant tumor cells developing in the muscles (rhabdomyosarcoma), while isoflavones from kudzu roots showed good anticarcinogenic effect against brain cancer (glioblastoma multiforme) and bone and connective tissue cancer (osteosarcoma). Studies were performed in vitro on cell lines of these diseases.   #isoflavones #kudzu #cancer    Aboushanab SA, Shevyrin VA, Slesarev GP, Melekhin VV, Shcheglova AV, Makeev OG, Kovaleva EG, Kim KH. Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS. Plants. 2022; 11(6):741. https://doi.org/10.3390/plants11060741
11:43
April 28, 2022
K2 (MK-7) From Depression To Dementia May be a Powerful Tool
K2 (MK-7) From Depression To Dementia May be a Powerful Tool
Vitamin K supplementation was associated with reduced evidence of cognitive impairment, depression and anxiety, along with improved spatial memory and learning ability. Elkattawy HA, Ghoneim FM, Eladl MA, Said E, Ebrahim HA, El-Shafey M, Asseri SM, El-Sherbiny M, Alsalamah RH, Elsherbiny NM, Hadhod S. Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats. Antioxidants. 2022; 11(3):514. https://doi.org/10.3390/antiox11030514 #k2 #depression #dementia Vitamin k2, menaquinone-7, Dementia, Alzheimer’s, neuro inflammation, cognitive impairment, depression, anxiety, spatial memory, learning ability, NLRP3, caspase-1, Il-1β, TNFα, IL-6,  CD68, k2, mk-7,  frontal cortex, hippocampal
12:16
April 13, 2022
CBD may reduce plaque and improve cognition in Alzheimer's
CBD may reduce plaque and improve cognition in Alzheimer's
A two-week course of high doses of CBD helps restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer's disease, and improves cognition in an experimental model of early onset familial Alzheimer's, investigators report. #alzheimer’s #CBD #plaque Hesam Khodadadi, Évila Lopes Salles, Abbas Jarrahi, Vincenzo Costigliola, MB Khan, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Babak Baban. Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer’s Disease. Journal of Alzheimer's Disease, 2021; 1 DOI: 10.3233/JAD-210026 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210026 cbd, cannabidiol,  Alzheimer's, familial Alzheimer's, plaque, beta amyloid, cognition, trem2, il-33, amyloid-beta, Triggering Receptor Expressed on Myeloid Cells 2, brain, cognitive, aging, accumulation, interlukin #trem2 #il33 #Alzheimers #cbd #cognition #plaque #amyloid #cannabidiol
08:35
March 17, 2021
B6 may help keep COVID-19's cytokine storms at bay
B6 may help keep COVID-19's cytokine storms at bay
Who would have thought that a small basic compound like vitamin B6 in the banana or fish you had this morning may be key to your body's robust response against COVID-19?  #B6​ #vitaminB6​ #cytokinestorm​ Thanutchaporn Kumrungsee et al, Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications, Frontiers in Nutrition (2020). DOI: 10.3389/fnut.2020.562051
10:18
March 12, 2021
Catnip a powerful New (Rediscovered) Bug Repellent
Catnip a powerful New (Rediscovered) Bug Repellent
Often used as an additive for cat toys and treats due to its euphoric and hallucinogenic effects on cats, catnip has also long been known for its powerful repellent action on insects, mosquitoes in particular. Recent research shows catnip compounds to be at least as effective as synthetic insect repellents such as DEET.  #catnip​ #mosquito​ #insectrepellent​   N. Melo et al. The irritant receptor TRPA1 mediates the mosquito repellent effect of catnip. Current Biology. Published online March 4, 2021. doi: 10.1016/j.cub.2021.02.010.
11:48
March 12, 2021
Real world data reveal risks of allergic reactions after receiving COVID-19 mRNA vaccines
Real world data reveal risks of allergic reactions after receiving COVID-19 mRNA vaccines
This episode is also available as a blog post: https://clinicalnews.org/2021/03/09/real-world-data-reveal-risks-of-allergic-reactions-after-receiving-covid-19-mrna-vaccines/
06:27
March 12, 2021
Breaking the warp barrier for faster-than-light travel
Breaking the warp barrier for faster-than-light travel
This episode is also available as a blog post: https://clinicalnews.org/2021/03/09/breaking-the-warp-barrier-for-faster-than-light-travel/
04:40
March 12, 2021
Concerns over integrity of mRNA molecules in some COVID-19 vaccines
Concerns over integrity of mRNA molecules in some COVID-19 vaccines
This episode is also available as a blog post: https://clinicalnews.org/2021/03/10/concerns-over-integrity-of-mrna-molecules-in-some-covid-19-vaccines/
03:31
March 11, 2021
FAIR Health releases study on impact of COVID-19 on pediatric mental health
FAIR Health releases study on impact of COVID-19 on pediatric mental health
This episode is also available as a blog post: https://clinicalnews.org/2021/03/02/fair-health-releases-study-on-impact-of-covid-19-on-pediatric-mental-health/
08:15
March 10, 2021
Covid-19 risk increases with airborne pollen
Covid-19 risk increases with airborne pollen
This episode is also available as a blog post: https://clinicalnews.org/2021/03/09/covid-19-risk-increases-with-airborne-pollen/
04:41
March 10, 2021