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Live Longer World

Live Longer World

By Aastha Jain

The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. Live Longer World takes you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future.

www.livelongerworld.com/
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#25 Caloric Restriction Deep-Dive & Longevity Secrets of Long-Lived Animals | Dr. Steven Austad
#25 Caloric Restriction Deep-Dive & Longevity Secrets of Long-Lived Animals | Dr. Steven Austad
All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad  Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!    There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.    Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/  Find me (Aastha) on Twitter: https://twitter.com/aasthajz  DR. STEVEN AUSTAD LINKS:  Website: https://www.stevenaustad.com/ Twitter: https://twitter.com/StevenAustad Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad  CONNECT WITH AASTHA, LIVE LONGER WORLD:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/aasthajz Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/aasthajz/  TIMESTAMPS:  0:00 Training lions  7:15 Learning from Long-lived species  9:55 Bowhead whales live 200 years  12:55 House sparrows & longevity  14:40 Study "successful" animals  18:10 Naked Mole Rats  20:45 What do bowhead whales die from?  26:05 Why do ocean animals live longest?  31:05 Beyond Caloric Restriction  36:00 Intermittent Fasting & Circadian Rhythm  42:40 Caloric Restriction for Healthy people?  46:24 Will coffee shorten your life?  49:43 The Blue Zone Myth  55:50 Young Blood, I can't get you of out my Mind  1:00:26 Hormones & Health (Growth Hormones for longevity?)  1:05:18 Sex differences in longevity  Episode Show Notes: https://livelongerworld.substack.com/p/saustad  POPULAR EPSIODES:  - Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA - Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg - Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 - Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 - Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo  Thanks for watching & if you enjoy the episode, let's spread the message on longevity.    You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.  Aging is universal. Let's unite in this fight. Stay in good health - Aastha.  
01:08:36
August 04, 2022
#24 Dr. Dominic D'Agostino | Modified Ketogenic Diet for Optimal Health & Exercise (Part 2)
#24 Dr. Dominic D'Agostino | Modified Ketogenic Diet for Optimal Health & Exercise (Part 2)
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.   This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode! Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1 Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajz SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld DOM D'AGOSTINO LINKS: KetoNutrition: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/DominicDAgosti2 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/aasthajz Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/aasthajz/ TIMESTAMPS: 0:00 Ketogenic diet for muscle performance  0:50 Dom’s supplements & modified keto diet  3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom  9:30 LDL, Triglycerides, Fatty Foods & Keto diet  14:15 Dom’s routine & supplements  18:09 Melatonin benefits for anti-cancer & antioxidant  22:37 Ketogenic diet for women  30:55 Ketogenic diet for children  32:48 Genetic aspect to keto diet?  38:32 Metformin for suppressing cancer  46:30 Ketogenic diet & Alzheimer’s   54:40 Exercise for mental health  55:53 Keto for exercise performance & bodybuilding  59:32 Endogenous metabolite & psychedelics  1:09:05 Connect with me (Aastha) Episode Show Notes: https://livelongerworld.substack.com/p/dom2 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
01:09:42
June 28, 2022
#23 Dominic D'Agostino | Ketogenic Diet for Brain Health and Longevity (Part 1)
#23 Dominic D'Agostino | Ketogenic Diet for Brain Health and Longevity (Part 1)
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1  Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.  This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode!   Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/  Find me (Aastha) on Twitter: https://twitter.com/livelongerworld  SUPPORT LIVE LONGER WORLD:  Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld  DOM D'AGOSTINO LINKS:  KetoNutrition: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/DominicDAgosti2 CONNECT WITH AASTHA, LIVE LONGER WORLD:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ TIMESTAMPS:  0:00 Ketogenic diet is not optimal for everyone  0:56 Dom D’Agostino Intro  1:29 Plant-based ketogenic diet  3:20 Ketogenic diet & brain protection against seizures  16:40 Ketone Esters & Salts  19:29 Does the brain need glucose?  21:37 Intermittent Ketosis & Fasting Mimicking Diet  25:17 Cyclic Ketogenic diet for longevity  28:40 Devices for tracking ketosis  30:30 Ketogenic diet for longevity vs. Caloric restriction  37:50 Keto diet for cancer prevention  41:57 Keto diet, Insulin pathway, and glucose  46:50 Time restricted eating benefits  50:17 Dom vs. Layne Norton on Joe Rogan podcast  51:40 Muscle for longevity (especially for women)  56:10 Support Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/dom1 Thanks for watching & if you enjoy the episode, let's spread the message on longevity.    You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.   Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
56:35
June 09, 2022
#22 The Cancer Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous
#22 The Cancer Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection.  Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him. It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!   Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/livelongerworld  SUPPORT LIVE LONGER WORLD:  Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld  SAM APPLE LINKS:  Ravenous book: https://amzn.to/3yT9qpd Website: http://www.samapple.com/ Twitter: https://twitter.com/Sam_Apple1 CONNECT WITH AASTHA, LIVE LONGER WORLD:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ TIMESTAMPS:  0:00 Cancer as a disease of modern societies  1:27 Otto Warburg & the Cancer-Metabolic Connection  2:27 Warburg’s research on respiration  4:02 Why was cancer skyrocketing in Western societies?  9:17 Warburg Effect: Warburg’s research on cancer cells  15:00 Why do cancer cells take up so much glucose?  17:44 Cancer-Diet Connection  21:44 Cancer, Ketogenic diets & Fasting  23:43 Hibernation of the metabolic story of cancer  27:20 Hitler’s connection with cancer  30:07 Warburg’s arrogance  31:51 Why does cancer need glucose?  38:46 Warburg’s stigma: connecting with Nazi’s  40:51 Is insulin responsible for cancer?  48:00 Science is not immune from politics  50:24 Prostate cancer & obesity  52:13 Pendulum swing in cancer research  54:40 Mitochondria & Cancer Connection  57:07 Nazi’s fixation on cancer Episode Show Notes: https://livelongerworld.substack.com/p/sapple  Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for listening & if you enjoy the episode, let's spread the message on longevity.  You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight.  Stay in good health - Aastha.
01:03:22
May 24, 2022
#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev
#21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev  Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab.  We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.    Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.   It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!   Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium  Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld Find me on Twitter: https://twitter.com/livelongerworld  VADIM GLADYSHEV LINKS:  Website: https://gladyshevlab.bwh.harvard.edu/2022  Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1  LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium  TIMESTAMPS:  0:00 Vadim Gladyshev Intro  1:28 Live Longer World  2:17 Selenium’s dual role in aging (the good, the bad, the ugly)  11:27 Antagonistic Pleiotropy  13:53 Selenium & Cancer  15:58 Selenium Dosage (don’t get too much!)  18:30 Reactive Oxygen Species, Antioxidants & Aging  22:30 Fundamental basis of Aging  24:09 Aging is damage  29:20 Single cell Epigenetic Clocks  34:22 Aging in the Womb  42:16 Parent’s lifestyle for aging in embryo  44:14 Rapamycin during development  49:06 Other compounds  51:53 Slowing Aging vs. Rejuvenation  56:08 New projects being worked on  57:17 Confidence level in extending lifespan within 30 years  59:17 Support Live Longer World   Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev  Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1  Thanks for watching & if you enjoy the episode, let's spread the message on longevity.    You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
01:00:17
May 10, 2022
#20 Cardiovascular Disease Risk Assessment & Ketogenic Diets for Heart Health | Dr. Ethan Weiss
#20 Cardiovascular Disease Risk Assessment & Ketogenic Diets for Heart Health | Dr. Ethan Weiss
Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.  In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more.    If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you.  All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast   Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium   Support on Patreon: https://www.patreon.com/livelongerworld  One-Time support: https://www.paypal.com/paypalme/livelongerworld   ETHAN WEISS LINKS:  Website: https://profiles.ucsf.edu/ethan.weiss  Twitter: https://twitter.com/ethanjweiss   LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/  Twitter: https://twitter.com/livelongerworld  Newsletter: https://livelongerworld.substack.com/  Instagram: https://www.instagram.com/longevityfuture/  Patreon: https://www.patreon.com/livelongerworld  YouTube: https://www.youtube.com/c/LiveLongerWorld  Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS:  0:00 Welcome to Live Longer World  0:44 Misconceptions of heart disease / young people with heart disease  4:01 Predictors of heart disease  6:59 LDL vs HDL; Triglycerides  12:51 Small-dense LDL vs. Large fluffy LDL  16:09 Dietary Carbohydrates & heart disease risk  25:50 Inflammation & Cardiovascular risk  26:43 Lipoproteins, ApoB, Lp(a)  31:31 Statins, PCSK9 inhibitors  32:45 ApoB as gold standard risk marker  36:50 Triglycerides & Insulin resistance  40:00 Saturated Fat  42:42 Variation in Cholesterol measurement  46:03 Body composition as marker for heart disease risk  51:23 Ketogenic diets & heart health  56:43 Keyto breath sensor  1:01:46 Stress & heart disease  1:04:44 Growth hormone & heart disease  1:07:46 On the shortness of life  1:10:52 Support & Connect with  Live Longer World  Episode Show Notes: https://livelongerworld.substack.com/p/eweiss  Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1  Thanks for listening & if you enjoy the episode, let's spread the message on longevity.  Aging is universal. Let's unite in this fight.  Stay in good health - Aastha.
01:11:51
May 03, 2022
#19 Michael Levin | Can Bioelectrical Signals Reverse Aging?
#19 Michael Levin | Can Bioelectrical Signals Reverse Aging?
Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology.   His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging.   Michael Levin’s work is fascinating and will surely leave you thinking. I hope you enjoy the conversation!    All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium  Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld  MICHAEL LEVIN LINKS:  Website: https://ase.tufts.edu/biology/labs/levin/ Twitter: https://twitter.com/drmichaellevin  LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/ Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium  TIMESTAMPS:  0:40 How do cells decide what to build?  10:05 DNA is insufficient for dictating collective intelligence of cells  19:00 Anatomical Complier (End game)  22:24 History of Cellular Collective Intelligence & Ala Turing  26:30 Regenerative Medicine & Morphoceuticals  38:05 Cells forming new anatomies  44:53 Cancer as a morphogenetic problem  55:16 David Sinclair, Bioelectrics to reverse aging  57:44 Synthetic Wombs & Artificial Life  59:41 Support Live Longer World! Episode Show Notes: https://livelongerworld.substack.com/p/mlevin  Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1  If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts.  And if you are further inclined to show love and support, you can donate on Patreon: patreon.com/livelongerworld Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight.  Stay in good health - Aastha.  
01:00:28
April 19, 2022
#18 Longevity Supplements - Interventions Testing Program Results | Dr. Richard Miller
#18 Longevity Supplements - Interventions Testing Program Results | Dr. Richard Miller
Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.   In today’s episode, you will learn:  - The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin  - 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril  - Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin  - Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more  - Richard’s thoughts on lifespan vs. healthspan   All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium  Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld  RICHARD MILLER LINKS:  Website: http://www.richmillerlab.com/ Photography: https://richardmiller.zenfolio.com/ Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp  LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS:  0:55 Richard Miller Intro  1:51 Richard Miller Wildlife photography  3:30 ITP - the gold standard for testing longevity drugs & winning drugs  10:51 Rapamycin, Rapamycin + Acarbose  18:48 Rapamycin + Acarbose Dosing Schedule  20:15 Combination of drugs, Rapamycin + Metformin  21:56 17-Alpha Estradiol  25:45 Canagaflozin  31:34 Does Richard take the 4 winning drugs?  32:46 3 Drugs that have small lifespan effects & promising  36:30 GPLD-1 & shared mechanisms in longevity drugs  44:04 Resveratrol in ITP  46:27 NR, NMN  52:34 Curcumin, Green Tea Extract, MCT Oil  54:54 Fisetin & Senolytics  56:12 Why most published research findings are false  1:00:03 Healthspan biomarkers at the ITP  1:02:38 Can you have healthspan without lifespan?  1:07:37 Fish Oil, Spermidine, Sulforophane  1:12:13 Unpublished data Richard is excited about  1:17:47 Flying Pigs & Aubrey De Grey  1:20:00 Exponential rise in aging research Episode Show Notes: https://livelongerworld.substack.com/p/rmiller Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast.  Aging is universal. Let's unite in this fight.
01:21:41
April 12, 2022
#17 Epigenetic Reprogramming, Yamanaka Factors, Cryonics & COVID Lab Leak | Yuri Deigin
#17 Epigenetic Reprogramming, Yamanaka Factors, Cryonics & COVID Lab Leak | Yuri Deigin
Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.    Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today’s episode!   As a last point to Yuri’s introduction, because I’d be remiss if I didn’t mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth.   In today’s episode, you will learn:  - The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair’s theory The Weak Epigenetic Theory of Aging)  - Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state   - What is it and what are the open questions in the field  - What are the cancer risks associated with it  - Why Yuri believes in Cryonics  - Why Yuri got interested in uncovering the COVID-19 Lab Leak theory   - Pharma in Russia If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin   Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast   Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium   Support on Patreon: https://www.patreon.com/livelongerworld  One-Time support: https://www.paypal.com/paypalme/livelongerworld YURI DEIGIN LINKS:  Twitter: https://twitter.com/ydeigin LinkedIn: https://www.linkedin.com/in/yurideigin/ Medium: https://yurideigin.medium.com/ YouthBio Therapeutics: https://youthbiotx.com/  LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS:  00:00 "We're not crazy"  0:37 100% life extension & translation to humans  4:28 Aging is potentially an engineering problem  12:45 Strong Epigenetic Theory of Aging  19:26 Epigenetic Reprogramming  29:00 Risk of Cancer with Epigenetic reprogramming  33:00 Rejuvenation without cancer risk?  38:30 Why Cryonics Makes Sense  48:00 COVID Lab Leak Theory  53:45 Pharma in Russia  58:40 Optimism in Longevity  1:00:50 Aging is Universal. Let's Unite in this Fight Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast.  Aging is universal. Let's unite in this fight.  Stay in good health - Aastha.
01:02:52
March 08, 2022
#16 Cancer, Cellular Senescence & Senolytics | Dr. Peter Adams
#16 Cancer, Cellular Senescence & Senolytics | Dr. Peter Adams
Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation. In today’s episode, you will learn: Cellular Senescence and it’s dual role in protecting against cancer but also causing tissue aging The role of senolytic drugs to protect against age-associated cellular senesence The connection between the mitochondria and cellular senescence The Developmental theory of aging (Aging begins in the womb!) If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld PETER ADAMS LINKS: Lab Website & Bio: http://www.padamslab.org/pages/members.html Peter Adams Twitter: https://twitter.com/AdamsBioAging Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams  Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
01:09:30
March 01, 2022
#15 Parkinson's Disease & Mitochondrial Dysfunction | Andy Lee, COO Vincere Biosciences
#15 Parkinson's Disease & Mitochondrial Dysfunction | Andy Lee, COO Vincere Biosciences
My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease.  In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinson’s. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company.    Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium  Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld  ANDY LEE / VINCERE BIO LINKS:  Vincere Website: https://vincerebio.com/ Andy Lee Twitter: https://twitter.com/andy_d_lee LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS:  0:00 Live Longer World Intro  0:34 Andy Lee & Vincere Bio Intro  1:55 Vincere & the connection between mitochondria & Parkinson's  7:39 Mitophagy & Parkinson’s disease  16:29 Role of USP30 in Mitochondria & Parkinson’s  22:26 Vincere small molecules testing  25:18 Other pathways affected during Parkinson's  30:53 Computation Biology Platform used by Vincere  36:50 Urolithin A & Coq10 to help with Parkinson’s  39:45 Biomarkers for Mitophagy  42:46 Too much mitophagy?  44:50 Challenges running a biotech company  48:19 Path forward for Vincere  49:36 Support, share and follow Live Longer World! Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science!    Key points summarized in the show notes for premium subscribers include:  1. The connection between Mitochondrial quality control & Parkinson’s disease  2. Mitophagy and the science behind targeting the mitochondria  3. Overview of the Biological Simulation Platform used by Vincere Bio  4. Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinson’s  5. Challenges with running a Biotech Co. Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium Ep. Show notes: https://livelongerworld.substack.com/p/alee
50:23
February 22, 2022
#14 Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair in Reproductive Cells
#14 Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair in Reproductive Cells
My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA damage.  A lot of us have heard about the link between DNA damage and aging and this conversation really dives into it.   All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bschumacher  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium  Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld  DR. BJORN SCHUMACHER LINKS:  Lab Website: https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher Twitter: https://twitter.com/schumacherbj Author of the book: The Mysteries of Human Aging: Surprising Insights from a Science That's Still Young: https://amzn.to/3LyR3JU LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS:  0:00 Live Longer World Intro  0:30 Bjorn Schumacher Intro  1:22 DNA Damage as Central to the Aging process  3:37 DNA repair with age  8:39 Premature aging; 2 distinct forms of DNA damage  14:15 How does an aging human survive with DNA damage & tamp down cancer?  18:20 Stress to reproductive cells builds up immunity in the body  24:41 Female reproduction, Menopause & DNA repair  27:46 p53 and it’s role in DNA repair  35:13 BiT Clock: New Biological Age Clock  43:59 Skin Aging and DNA damage  48:06 Stress in the intestine / gut can alter the chromosome  53:00 Germ cells are immortal For links to DR. Bjorn Schumacher research discussed: https://livelongerworld.substack.com/p/bschumacher Want Summarized Notes on Key Points Discussed in the Podcast?  Gain access by signing up as a premium subscriber. Your contribution supports my work the advancement of longevity science! Key points summarized in the show notes for premium subscribers include: The central role of DNA damage in the aging process What happens to our body’s DNA repair mechanism with age? DNA Damage in the germ cells (reproductive cells) promotes stress resistance in the body The role of p53 in suppressing cancer and in the DNA repair process Learn more: https://www.livelongerworld.com/premium Thanks for listeni
55:48
February 15, 2022
#13 Dr. David Gems | Hyperfunction & Programmatic Theory of Aging and Critique of the Hallmarks of Aging
#13 Dr. David Gems | Hyperfunction & Programmatic Theory of Aging and Critique of the Hallmarks of Aging
My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the cause of aging, but the programmatic theory of aging shows that that might not be the case. We also discussed his critique of the hallmarks of aging and how there should be a better paradigm for the aging field. Lastly, we also discussed how research from his lab on C. Elegans might explain some of the conflict around whether sirtuins affect lifespan and how C. Elegans also show versions of this programmatic theory of aging, which can give us a better understanding of how to study aging. Note: There is a point in the conversation (40:41) where David pulls up some slides to better explain the Multifactorial Model of Aging. So if you are listening to the audio version, you might want to refer to YouTube or the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/dgems  Support on Patreon: https://www.patreon.com/livelongerworld   Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast   DR. DAVID GEMS LINKS:  Lab Website: https://www.ucl.ac.uk/~ucbtdag/DGHistory.html  LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS:  00:00 Live Longer World  00:25 David Gems Intro  1:47 History of the theories of aging  12:23 Hyperfunction / Programmatic Theory of Aging  24:57 Programmatic Theory of Aging in C. Elegans  36:59 Hyperfunction theory of Aging in Humans  40:41 Multifactorial Model of Aging 50:32 Mutation in C. Elegans affecting Sirtuin research?  59:57 Sirtuin research in humans & conflicting sirtuin research  1:04:44 Metformin affects the gut microbiome  1:07:41 Critique of the Hallmarks of Aging  1:16:12 Disruption in Early Life could lead to Aging related diseases  1:24:23 Support, share, and follow Live Longer World To find links to David Gems research discussed, please refer to the show notes: https://livelongerworld.substack.com/p/dgems  Thanks for listening & if you enjoy the episode, please leave a review on Apple podcasts, support on Patreon, subscribe & share!   Stay in good health - Aastha.
01:24:58
February 08, 2022
#12 Dr. Bruce Ames | Longevity Micronutrients, Triage Theory, and Vitamin D for Healthy Aging
#12 Dr. Bruce Ames | Longevity Micronutrients, Triage Theory, and Vitamin D for Healthy Aging
My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas!    Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage.    Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8).   I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people.    This is a shorter episode and I hope you learn more about the importance of micronutrients!   All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames   RELATED WRITING:  My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames  My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods   Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  Find me on Twitter: https://twitter.com/livelongerworld Support on Patreon: https://www.patreon.com/livelongerworld  DR. BRUCE AMES LINKS:  Website: http://www.bruceames.org/  LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium  TIMESTAMPS:  00:00 Live Longer World  00:36 Bruce Ames Intro  1:50 Micronutrient triage theory  5:40 Micronutrient deficiencies & age acceleration  9:10 Vitamin D for healthy aging  12:26 CHORI Bar  14:46 Measuring micronutrients (blood finger-prick)  16:55 Bruce Ames diet  18:19 Asthma caused by obesity / bad diet improved by CHORI bar  21:21 Dr. Ames lifestyle over the years  22:47 Importance of zinc  24:15 Nutrition is complicated  24:44 Dr. Ames last words & advice for young scientists Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.
27:43
February 01, 2022
#11 Dr. Brian Kennedy | Aging Networks & Biomarkers, AKG, Spermidine and Longevity of Bats
#11 Dr. Brian Kennedy | Aging Networks & Biomarkers, AKG, Spermidine and Longevity of Bats
My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research.  Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity.  In today's discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.   All platforms / Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/bkennedy  Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  Support on Patreon: https://www.patreon.com/livelongerworld  DR. BRIAN KENNEDY LINKS:  Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/ Twitter: https://twitter.com/BKennedy_aging  LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium  DR. BRIAN KENNEDY RESEARCH DISCUSSED:  2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/  2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/  2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/  2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/  2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/  2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081 Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share!  Stay in good health - Aastha.
58:26
January 25, 2022
#10 Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging
#10 Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging
My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin’s lab is also working on establishing the ECM as a biomarker for health and disease risk. So, studying the ECM can indeed tell us a lot about the aging process and ways to intervene. Think of the ECM as the environment that surrounds the cell or the proteins secreted from the cell. It holds our organs and tissues in place. You’ve probably heard of collagen protein - it is largely found in the ECM. Why is the ECM relevant for longevity research? Turns out, the ECM changes with age. In fact, each cell has a unique ECM and cancer cells can be detected by their ECM composition type! There is also a connection between the ECM and the muscle, and damage to collagen with age results in weakening of our muscles. We discuss changes in collagen with age, how sugar impacts collagen, cancer cells & ECM, the overexpression of certain collagens with age, changes in collagen causing muscle impairment with age, and longevity interventions his lab is studying to repair the impairment damage. (This podcast can be a little technical, especially in the beginning, so I’d recommend referring to the show notes for better understanding. The video version of the podcast also contains some explanations on the video slide itself.) All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/cewald   Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium   Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast   Support on Patreon: https://www.patreon.com/livelongerworld   DR. COLLIN EWALD LINKS:  Lab Website: https://www.ewaldlab.com/  Twitter: https://twitter.com/CollinEwald    LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/  Twitter: https://twitter.com/livelongerworld  Newsletter: https://livelongerworld.substack.com/  Instagram: https://www.instagram.com/longevityfuture/  Patreon page: https://www.patreon.com/livelongerworld  Podcast All Platforms: https://anchor.fm/livelongerworld  YouTube: https://www.youtube.com/c/LiveLongerWorld  Apple Podcasts: https://apple.co/3eZAoAp  Spotify: https://spoti.fi/3eZB6O5  Google Podcasts: https://bit.ly/3HN0keG  Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: Episode Page: https://livelongerworld.substack.com/p/cewald  YouTube: https://youtu.be/r1Y5wGSqKWA DR. COLLIN EWALD RESEARCH:  The Matrisome during Aging and Longevity: https://www.karger.com/Article/FullText/504295  Collagen overexpression increasing lifespan: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/  Youthful and age‐related matreotypes predict drugs promoting longevity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441316/  Doubling life near death: https://elifesciences.org/digests/71335/doubling-life-near-death Thanks for watching & if you enjoy the episode, please like, comment, leave a review, subscribe & share!  Stay in good health - Aastha.
01:02:15
January 18, 2022
#09 Dr. Irina & Michael Conboy | Tissue Rejuvenation Via Plasma Dilution, Neutral Blood Exchange and Parabiosis
#09 Dr. Irina & Michael Conboy | Tissue Rejuvenation Via Plasma Dilution, Neutral Blood Exchange and Parabiosis
My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley.  Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They’ve also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!!    Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in today’s episode.   Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium  Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast  DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/   2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/   2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/   2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082   LIVE LONGER WORLD LINKS:  Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5  Google Podcasts: https://bit.ly/3HN0keG TIMESTAMPS:  00:00 Live Longer World Intro  00:35 Irina & Michael Conboy Intro  1:08 Aging is slowdown in our repair machinery  2:55 Naked Mole Rats not extreme model for longevity  5:37 Heterochronic Parabiosis  16:00 Young Blood to Old Blood Exchange  19:19 Rejuvenation via Neutral Blood Exchange (NBE)  22:56 Old Blood Degenerates Young Mice  25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE  27:16 How long do effects of NBE last?  30:15 How is NBE working mechanistically? 2 waves of rejuvenation  33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative  38:12 NBE vs. Senolytics  40:53 Unanswered Questions on NBE  43:13 Oxytocin & Muscle Functioning; Notch Signaling  48:12 Chickens & Ravens as Pets!   Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.
50:04
January 11, 2022
#08 Nir Barziali | Metformin, TAME Trial & Centenarian Longevity Research
#08 Nir Barziali | Metformin, TAME Trial & Centenarian Longevity Research
Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.  Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today’s episode and also in his book Age Later.   He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.   In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage.  Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai FOLLOW NIR BARZILAI:   Profile: https://einsteinmed.edu/faculty/484/nir-barzilai/   Twitter: https://twitter.com/NirBarzilaiMD   Book: https://us.macmillan.com/books/9781250230867   FOLLOW LIVE LONGER WORLD:   Website: https://www.livelongerworld.com/   Twitter: https://twitter.com/livelongerworld   Newsletter: https://livelongerworld.substack.com/   Instagram: https://www.instagram.com/longevityfuture/   Podcast All Platforms: https://anchor.fm/livelongerworld   Patreon: https://www.patreon.com/livelongerworld   YouTube: https://www.youtube.com/c/LiveLongerWorld   Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541   Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC
01:01:52
January 04, 2022
#07 2021 Best of Live Longer World | Longevity Science
#07 2021 Best of Live Longer World | Longevity Science
The final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode.   Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogramming, Atherosclerosis, Brain Aging and more.  And if a particular topic or clip captures your attention, you can of course go and watch the entire podcast episode.  Hope you enjoy it and wishing everyone a happy & healthy holiday season! Episode Show Notes: https://livelongerworld.substack.com/p/2021 Find the previous podcast episodes: https://www.livelongerworld.com/podcast 2021 Live Longer World podcast episodes: #01: Reason, founder & CEO of Repair Biotechnologies #02: Dr. Jean Hebert on Tissue Replacement in the Brain #03: Carolina Oliveira, the founder & CEO of OneSkin #04: Dave Gobel, founder & CEO of Methuselah Foundation #05: Dr. Matt Kaeberlein on Aging Interventions, Rapamycin, mTOR #06: Dr. Morgan Levine on Epigenetic Clocks, SystemsAge Clock FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Podcast All Platforms: https://anchor.fm/livelongerworld Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC
54:28
December 21, 2021
#06 Morgan Levine | Epigenetic Clocks, SystemsAge Clock and Epigenetic Reprogramming
#06 Morgan Levine | Epigenetic Clocks, SystemsAge Clock and Epigenetic Reprogramming
Dr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease. I can’t even begin to tell you how much I learned in today’s conversation! We extensively discussed Morgan’s work on developing a new Epigenetic clock called the SystemsAge clock, which is very cool and can test the biological age of different organs & systems in your body. We also spoke of different features of these clocks, interventions tested, what we know so far on reversing your biological age, some of the limitations of the clocks, why she is so excited about epigenetic reprogramming, and some of her work around Alzheimer’s disease. Most people are interested in knowing their biological age and epigenetic clocks are a way to test it. So I’m sure you will find this conversation on epigenetic clocks fascinating and walk away understanding them much better! I hope you enjoy my conversation with Dr. Morgan Levine. Show notes + Timestamps: https://livelongerworld.substack.com/p/mlevine FOLLOW DR. MORGAN LEVINE:   Morgan's Lab: https://www.morganlevinelab.com/   Twitter: https://twitter.com/DrMorganLevine   FOLLOW LIVE LONGER WORLD:   Website: https://www.livelongerworld.com/   Newsletter: https://livelongerworld.substack.com/   Twitter: https://twitter.com/livelongerworld   Patreon: https://www.patreon.com/livelongerworld   Instagram: https://www.instagram.com/longevityfuture   Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541   Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC
01:15:33
November 30, 2021
#05 Matt Kaeberlein | Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project
#05 Matt Kaeberlein | Aging Interventions - Rapamycin, mTOR, CR, Sirtuins, NAD+ & Dog Aging Project
Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.   Matt has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive conversation where we spoke about how Matt thinks of aging from a functional perspective, caloric restriction and aging, whether NAD+ precursors are effective in slowing aging, the role of sirtuins.    We discuss quite a bit on rapamycin and how it’s shown to be effective in improving the health of mice. Matt is very excited about the potential benefits of Rapamycin in reversing aging and he got me excited too. Matt is also working on the Dog Aging project and in trying to understand aging in dogs.    Finally, we end the conversation by talking a bit on what good scientific practices should look like. Matt approaches his work with an unbiased lens and that’s very respectable. Matt has a brilliant mind! I had such a blast talking to Matt and I hope you enjoy the conversation as much as I did!  Timestamps in the YouTube version of this podcast: ttps://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg FOLLOW LIVE LONGER WORLD: Twitter: https://twitter.com/livelongerworld Website: https://www.livelongerworld.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Patreon: https://www.patreon.com/livelongerworld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC Instagram: https://www.instagram.com/longevityfuture/ Store: https://www.longevitystore.co/ FOLLOW MATT KAEBERLIN:   Website: https://kaeberlein.org/  Twitter: https://twitter.com/mkaeberlein  Dog Aging Project: https://dogagingproject.org/ 
01:33:31
November 17, 2021
#04 Dave Gobel, Founder & CEO of Methuselah Foundation | Longevity Funding, Regenerative Medicine & Longevity Escape Velocity
#04 Dave Gobel, Founder & CEO of Methuselah Foundation | Longevity Funding, Regenerative Medicine & Longevity Escape Velocity
My guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that! Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah including Oisin Biotechnologies, the concept of longevity escape velocity, his work with the super centenarian research foundation, how one can get involved in funding longevity companies and more. I hope you enjoy the episode! TIMESTAMPS: 0:00 Live Longer World Intro 1:30 David Gobel & Methuselah Foundation Intro 2:00 Dave's work at the TSA; Innovation at TSA 10:39 Methuselah Fund, How Dave got interested in Longevity & met Aubrey De Grey 19:14 The current healthcare system does not focus on preventative medicine; Aging is the biggest risk factor for all diseases 20:40 Methuselah Foundation mission - Making 90 the new 50 by 2030 26:56 Companies funded by Methuselah - Turnbio, Epigenetic reprogramming, Organovo 3D Tissue Printing 30: 18 Leucadia Therapeutics & working to erase Alzheimer's disease 37:20 Donating to Longevity 38:24 Investing in Longevity - how to get started 40:20 Vascular Tissue Challenge with NASA 43:05 Longevity Escape Velocity 47:28 Challenges in the Longevity Field (Money comes to winning solutions & ideas!) 51:55 Do we use money or does money use us? 57:00 Ending remarks FOLLOW LIVE LONGER WORLD:   Newsletter: https://livelongerworld.substack.com/   Twitter: https://twitter.com/livelongerworld   Website: https://www.livelongerworld.com/   Instagram: https://www.instagram.com/longevityfuture/   Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541   Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC   Patreon: https://www.patreon.com/livelongerworld   Store: https://www.longevitystore.co/   FOLLOW METHUSELAH FOUNDATION:   Website: https://www.mfoundation.org/   Twitter: https://twitter.com/mfoundation
58:31
November 11, 2021
#03 Carolina Oliveira, the founder & CEO of OneSkin Technologies | Skin Aging, OneSkin, and Building a Longevity Company
#03 Carolina Oliveira, the founder & CEO of OneSkin Technologies | Skin Aging, OneSkin, and Building a Longevity Company
Carolina Reis Oliveira is the founder & CEO of OneSkin Technologies. OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging. Carolina holds her Ph.D. in Immunology at the Federal University of Minas Gerais in collaboration with the Rutgers University and is an alumnus of IndieBio, the world's leading biotechnology accelerator. In 2016, Carolina relocated to Silicon Valley from Latin America to co-found OneSkin, and to lead the development of the company’s disruptive rejuvenation technologies. Carolina is full of energy and I really enjoyed talking to a scientist entrepreneur! 0:00 Live Longer World Intro  1:06: Carolina & OneSkin Intro  2:25 Jokes, Pleasing Indian Mom 4:00 Skin Aging; Cellular Senescence  8:05 Skin Overlooked in Longevity Research; Concentration of Senescent Cells in Skin  11:30 OneSkin Product; OS-1 Peptide  17:35 Does the product work across ethnicities & skin types?   20:55 Results from product; elimination of senescent cells  23:42 Senomorphics (slow down progression of senescent cells)  25:50: Results from studies in C. Elegans  30:31 OneSkin vs. Fistein vs. Retinol  35:21 Recommendation if using Retinol  37:21 Senolytic Drugs vs. OneSkin  40:19 Skin aging from Sun Damage  42:17 Which age to start using OneSkin?  44:47 Human Studies for OS-1  49:08 FDA Approval for drugs  51:00 Future products  53:47 Excitement about Longevity Industry  56:47 Connect with OneSkin  58:17 Connect with Live Longer World FOLLOW LIVE LONGER WORLD: Newsletter: https://livelongerworld.substack.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Twitter: https://twitter.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld Apple Podcasts: https://podcasts.apple.com/us/podcast/live-longer-world/id1588806541 Spotify: https://open.spotify.com/show/2Zc65BZb02msGuF9ujBThC Store: https://www.longevitystore.co/ Website: https://www.livelongerworld.com/ FOLLOW ONESKIN: Website: https://www.oneskin.co/ Instagram: https://www.instagram.com/oneskin.co/ LinkedIn: https://www.linkedin.com/company/oneskin/ Twitter: https://twitter.com/OneSkinTech
01:00:01
November 03, 2021
#02 Dr. Jean Hebert | Brain Aging, Tissue Replacement, and Radical Strategy to Fight Aging (Potentially Forever!)
#02 Dr. Jean Hebert | Brain Aging, Tissue Replacement, and Radical Strategy to Fight Aging (Potentially Forever!)
Jean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York. Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and defeat aging. He is a molecular geneticist by training and obtained his Ph.D. from the University of California, San Francisco, before specializing in the study of how neural stem cells form the brain at Stanford University. His lab is now developing ways to use cell and tissue replacements to repair and rejuvenate the brain. More specifically, the Hébert Lab is engineering tissue that increasingly resembles normal neocortex, the part of our brain that performs our highest cognitive functions, and testing the ability of this tissue to integrate with the host brain. Jean is the author of Replacing Aging. We had an extremely interesting conversation ranging from why Dr. Hebert thinks the other methods to fight aging may not work if the goal is to beat aging, we discuss 3D organs and tissue cell replacement and we also discuss the neocortex and what it takes to replace one and lastly we talk about how plasticity in the brain works.  Even if you are not associated with the field of longevity, you’ll find this conversation interesting and refreshing. FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Newsletter: https://livelongerworld.substack.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Twitter: https://twitter.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld Store: https://www.longevitystore.co/ FOLLOW DR. JEAN HEBERT: Twitter: https://twitter.com/Replacing_Aging Website: https://hebertlab.einsteinmedneuroscience.org/
01:04:57
October 26, 2021
#01 Reason, the Founder & CEO of Repair Biotechnologies | How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis
#01 Reason, the Founder & CEO of Repair Biotechnologies | How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis
Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem. Reason is perhaps most well known for his popular blog Fight Aging! where he distills the latest research in aging science. For anyone looking to stay informed on aging & longevity research, I highly recommend you checking it out - it’s one of the best resources out there. In today’s conversation, we discuss how to think of aging simply, the differences between slowing and reversing aging, NAD+ boosters and their effectiveness, reversing aging using senolytics, how his company is working on a gene therapy to reverse artherosclerosis and cardiovascular disease, problems with Alzheimer's research, working towards aging rejuvenation therapies, how one can get involved in the aging space, and much more. Note: We discuss a fair bit on cellular senescence and senolytic therapies. For those unfamiliar with the concept, cellular senescence is a process in which cells lose their ability to divide but refuse to die. When these senescent cells don’t get cleared away, they release harmful substances and damage the cells around them too. It is well known that senescent cells accumulate with age, contributing to inflammation and aging itself. Senolytics is a class of drugs that can selectively clear away these senescent cells and they have shown promise in delaying and preventing age-related diseases. FOLLOW LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Newsletter: https://livelongerworld.substack.com/ YouTube: https://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg Twitter: https://twitter.com/livelongerworld Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld Store: https://www.longevitystore.co/ FOLLOW REASON AND REPAIR BIOTECHNOLOGIES: Fight Aging! Blog: https://www.fightaging.org/ Company Website: https://www.repairbiotechnologies.com/
01:04:47
October 12, 2021
Introducing Live Longer World
Introducing Live Longer World
"Can I really live to be 200? Can I feel like I’m 20 when I’m 70? Can aging be reversed? Hold up, what even is aging? Now I’m curious to know about aging and longevity science!" Well then, you're at the right spot! Hello and welcome to Live Longer World! The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. We take you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future. To stay informed on what the future of aging and longevity looks like, make sure to subscribe to Live Longer World at Apple podcasts, Spotify, YouTube or wherever you get your podcasts. We look forward to transforming how we age in the future and bring you along on this wonderful journey.
01:21
October 04, 2021