
The Uromigos
By The Uromigos
Hosted by Brian Rini and Tom Powles
Brian Rini MD is a Professor of Cancer Research and Professor of Medicine (Hematology/Oncology), Vanderbilt-Ingram Cancer Center
Tom Powles is the Director of Barts Cancer Centre, St Bartholomew's Hospital and Professor of Genitourinary Oncology, Queen Mary University of London


Episode 424: ASCO 2025 - Emergency podcast on the prostate rapid oral session
Jorge Garcia joins us to discuss the process of selecting abstracts for oral presentation and select highlights from this session.

Episode 423: ASCO 2025 - Casdatifan plus Cabo in refractory RCC
Toni Choueiri discusses this combination cohort of HIF inhibition plus VEGF-R inhibition.

Episode 422: ACSO 2025 - ctDNA data from NIAGARA
Matt Galsky discusses the ASCO 2025 data regarding ctDNA from the NIAGARA neoadjuvant chemo +/- durvalumab study.

Episode 421: ASCO 2025 - Maintenance Avelumab +/- SG in Advanced Bladder Cancer
Jeannie Hoffman-Censits discusses her randomized phase 2 adding SG to maintenence avelumab in mUC.

Episode 420: ASCO 2025 - CheckMate 901: Ipi/Nivo vs chemo for Cis-ineligible metastatic urothelial cancer
Michiel Van Der Heijden joins us to discuss the Ipi/Nivo vs chemo randomization in this trial from his ASCO 2025 presentation

Episode 419: ASCO 2025 - Correlate data from the IMmotion 010 RCC adjuvant study
Monty Pal discusses more correlates from this trial including matched baseline and progression tissue samples.

Episode 418: ASCO 2025 - Biomarkers in RCC
David McDermott joins us on the heels of his outstanding discussion of the clinical science symposium on RCC biomarkers.

Episode 417: ASCO25 GUの注目演題について3人でDiscussion!!
Practice Changing? 独断と偏見で選んだ注目演題について結果の予想も含めて議論しました。

Episode 416: ASCO 2025 Preview
Silke, Tom and Brian discuss what they are looking forward to at ASCO 2025

Episode 415: Uromigos Score 前立腺がん編
日本と海外の違いはあるのか?mHSPCとmCRPCのUromigos Scoreについて激論!!

Episode 414: Uromigos score en cáncer de próstata metastasico - más allá de las guías clínicas
Edición especial en castellano con Alfonso Gómez de Liaño y Guillermo de Velasco. David Lorente da su visión sobre el nuevo Uromigos Score, que clasifica distintas opciones de tratamiento en varios escenarios de cáncer de próstata metastásico

Episode 413: The Uromigos Score for Advanced Prostate Cancer
Silke and Chris joins us to discuss our latest 'Uromigos Score' in which experts score the value of treatments for advanced prostate cancer. Several interesting themes emerge.

Episode 410: AUA 2025 - BOND-003 Cohort C: Cretostimogene in BCG-Unresponsive NMIBC
Mark Tyson from Mayo Clinic joins the podcast to discuss this replicating adenovirus and a high CR rate in BCG-unresponsive NMIBC

Episode 412: AUA 2025 - TAR-200 Monotherapy in BCG-Unresponsive NMUIBC from SunRISe-1
Joe Jacob joins the show to discuss the longer-term follow up of this cohort from SunRISe-1. We discuss definitions of CR and regulatory issues around drug approval in this space as well.

Episode 411: Live from EIKCS in Amsterdam - RCC Highlights
Viktor Grunwald joins to discuss the new data session from EIKCS

Episode 409: AUA 2025 - CREST - BCG +/- Sasanlimab in high-risk NMIBC
Neal Shore joins the show to discuss these exciting data from the American Urological Association Annual Meeting

Episode 408: Uromigos Japan - European Delphi Study of mRCCについてdiscussion
今月Eur Urol OncolにPublishされたヨーロッパのエキスパートによるmRCCのコンセンサスについて日本との違いについて深い議論をしました!!

Episode 407: Drug Development in China: Part 2 of 2
Part 2 of our series dives deeper into the explosion of ADC clinical drug development in China

Episode 406: Drug Development in China: Part 1 of 2
Drs. Dingwei Ye and Yao Zhu from China join the show to talk about drug development in China amid the recent surge of GU clinical trials.

Episode 405: The Good News About Cancer podcast
Drs. Alicia Morgans and Chuck Ryan join the show to talk about their new podcast.

Episode 404: 177 Lu-PSMA Pre-chemotherapy in mCRPC. Final Podcast from the Canary Islands
Elena Castro joins Tom and Brian on the day after Pluvicto approval pre-chemotherapy in the US to discuss the PSMA Fore data and application in clinical practice.

Episode 403: ADCs in Bladder Cancer. Part 2 from the Canary Islands
Ignacio Duran continues his discussion with Brian and Tom regarding novel ADCS in bladder cancer

Episode 402: Uromigos en Espanol: Futuro del carcinoma de células renales
Cristina Suárez analiza los próximos ensayos clínicos que podrían transformar el manejo del cáncer renal en los próximos años: nuevas combinaciones adyuvantes y estrategias perioperatorias, el uso de tripletes enprimera línea y la integración de inhibidores de HIF con TKIs, entre otros.

Episode 401: ADCs in Bladder Cancer. Part 1 from the Canary Islands
Ignacio Duran joins the show to discuss the landscape of established ADCs in urothelial cancer and challenges of drug development in this setting.

Episode 400: The Uromigos Score for Urothelial Cancer
Live from the Canary Islands 'Big Idea' talk from Tom, we discuss the new Uromigos Score which ranks different treatment options in several urothelial cancer settings.

Episode 399: A PD1/VEGF Bispecific in Lung Cancer - Lessons for GU Cancers?
Dr. John Heymach from MD Andersons joins us to discuss a novel PD1/VEGF bispecific agent in lung cancer and if there are applicaitons in GU malignancies.

Episode 398: Reflections on the Felix Feng Symposium at ASCO GU
Chuck Ryan joins us to discuss his interview with Felix and reflects on his keynote address at ASCO GU 2025.

Episode 397: APCCC Diagnostics Conference recap
Silke Gillessen joins us to discuss the top areas of consensus and controversy from APCCC 2025

Episode 396: Uromigos Japan - 激論 @JSMO25
尿路上皮癌と腎癌の臨床に影響を与えるエビデンスをどう解釈するか!?

Episode 395: Uromigos Japan: ASCO GU 2025のレビュー
ASCOGU2025で発表された臨床試験の結果の解釈について忖度なしに議論しました!!

Episode 394: APCCC (Advanced Prostate Cancer Consensus Conference) Diagnostics 2025
Tyler Seibert from UCSD joins the show live from Lugano to discuss meeting highlights and controversies (and his favorite run along the water..)

Episode 393: ASCO GU 2025 Review Podcast
Silke joins Tom and Brian to discuss highlights form ASCO GU 2025

Episode 392: ASCO GU 2025 - HIF Inhibition with Casdatifan in Refractory RCC
Toni Choueiri discusses the updated data from different cohorts of this novel HIF inhibitor.

Episode 391: ASCO GU 2025 - KIM-1 Data from Checkmate 214
Vincent Xu discusses this emerging RCC biomarker and data from the Checkmate 214 trial

Episode 390: ASCO GU 2025 - Pembro-based Doublets in Refractory RCC and COSMIC-313 OS Update
Laurence Albiges joins the show to discuss novel combos in refractory RCC and an update of the Ipi/Nivo/Cabo COSMIC OS data

Episode 388: ASCO GU 2025 - FGF3 Inhibition with LOXO-435 in Urothelial Cancer
Gopa Iyer from MSKCC joins the show to discuss his initial results from this phase 2 trial.

Episode 387: ASCO GU 2025 -Neoadjuvant Disitamab Vedotin + Toripalimab in HER2+ MIBC: updated efficacy and safety results
Xinan Sheng. M.D., Professor in the Department of Genitourinary Oncology at Peking University Cancer Hospital &institute in Beijing, China joins us to discuss the update of this trial and impressive pCR rates.

Episode 389: ASCO GU 2025 - NIAGARA Pathologic CR Updates and Outcomes
Matt Galsky joins the show to discuss pCR in NIAGARA and clinical implications.

Episode 386: ASCO GU 2025 - APRI Meta-analysis
Tanya Dorff from City of Hope joins us to discuss clinical implications of these data and also comment on TALAPRO-2

Episode 385: ASCO GU 2025 - TALAPRO-2
Neeraj Aggarwal joins Tom and Brian for an in-depth look at these important data

Episode 384: ASCO GU Preview
Silke Gillessen joins Brian and Tom and they discuss what to look forward to in prostate, bladder and RCC at ASCO GU 2025.

Episode 383: A Neoantigen Vaccine Generates Anti-tumor Immunity in RCC
David Braun joins the show to discuss his Nature paper on a personalized RCC vaccine

Episode 382: Uromigos Japan - TROPICs-04の考察
残念ながらNegative StudyとなったTROPICs-04についてUromigos Japanの3人が忖度なしに、その原因や理由について考察をします!!

Episode 381: Molecular heterogeneity in urothelial carcinoma and determinants of clinical benefit to PD-L1 blockade
Romain Banchereau joins the show to discuss and debate this Cancer Cell paper on molecular subtypes in urothelial cancer and implications for checkpoint blockade.

Episode 380: The Role of SBRT in RCC
Shankar Siva joins the show to discuss the emerging role of stereotactic body radiotherapy (SBRT) in primary and metastatic RCC tumors.

Episode 379: Uromigos Japan: 2024年のGU Oncologyを振り返る
3人による2024年のGU oncoloyのレビューを切れ味鋭く解説しています。乞うご期待!

Episode 378: 2025 Preview of Important GU Data
Tanya Dorff from City of Hope joins Brian and Tom to review what to expect throughout 2025 and beyond in terms of clinically impactful data in prostate, renal and bladder cancer

Episode 377: Prostate Cancer 2024 Highlights
Silke Gilleson gives Tom and Brian 3 'gifts': Thomas Zilli (Radiation Oncology), Jochen Walz (Urology) and Ken Hermann (Nuclear Medicine) who discuss the 2024 prostate highlights from each of their unique perspectives.

Episode 376: Bladder Cancer 2024 Highlights
Matt Galsky joins Brian and Tom to discuss the most impactful data in bladder cancer form the past year.

Episode 375: Renal Cancer 2024 Highlights
David McDermott (and his dog, Finn) join the show to review the top data from 2024 in RCC