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To Health With That! MTHFR Mutations.

To Health With That! MTHFR Mutations.

By Amy Neuzil
This podcast breaks up BIG health topics, like MTHFR, into small, easy bites that add up to in-depth knowledge. All in ten minutes or less.
We'll talk about why folic acid can be toxic, how the MTHFR enzyme is in bed with estrogen (scandalous!), why it matters to be able to turn some genes off, and why high-folate foods make some people feel depressed, and so much more

Check the show notes at for tips, tricks, downloadables and more. If you love the show, become a patron at Patreon and help keep the information coming.
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Are you "Infertile" without even knowing it?

To Health With That! MTHFR Mutations.

Four Phases of A "Normal" Menstrual Cycle
To begin to talk about what is abnormal about women's menstrual cycles, we have to first understand what is normal.  Most doctors and experts tend to talk about the two phases of a menstrual cycle, but to more accurately represent the lived experience of having a menstrual cycle, I think four phases are more accurate. These are: Menstrual Follicular Ovulatory Luteal Each phase has its own level of energy, physical changes, and of course hormone processes in the body. Each one also tells us a little bit about how you feel in the world at that time of the month. Let's talk about it! To see the video version of this podcast or read the show notes, go here. To join Genetic Rockstars, the incredible community of people working on optimizing their genetics and getting better together, click here. If you're interested in learning in a course from Dr. Amy, see our course offerings here and if you'd like to schedule a one-on-one consult, please click here.
October 02, 2022
Why Diagnosis Matters For Fertility
It's really tempting to avoid the diagnosis part of fertility - you can just get a bit healthier and it will all work out, right? Except for when it won't. Listen to Dr. Kate Naumes, ND and Dr. Amy Neuzil, ND talk about the biggest reasons why diagnosis is important if you're working on fertility.  Here's a hint: The problem might not even be with you. You can watch the video version and read the show notes and research here. To learn more about Dr Kate, go to For more about Dr. Amy, go to  If you're interested in upcoming courses on seed cycling for hormone balance or preferability, join the mailing list at If you happen to be working on your epigenetic health and want to join the most amazing community on the internet, check out Genetic Rockstars.
September 25, 2022
Are you "Infertile" without even knowing it?
For the first episode of this season on infertility, hormones, and how it all ties in with genetics - let's actually talk about what "infertility" means and why you might have passed some major benchmarks without even knowing it. Meet Dr. Kate Naumes, ND our fertility expert and see Dr. Amy Neuzil, ND in the video version. Watch the video version here: What is Infertility anyway? Visit Dr. Kate at, or Dr. Amy at If you're interested in taking a course on MTHFR or joining the mailing list for future courses on hormones and infertility, sign up here.
September 18, 2022
S2E45: MTHFR and Vaccines
The internet is full of doomsday prophecies about MTHFR and vaccines, but what does the actual science say? In this episode we'll cover: Dr. Amy's general views of vaccines MTHFR data in the Vaccine Adverse Event Reporting System in the US MTHFR and the smallpox vaccine research A case report about MTHFR and blood clots after the covid-19 vaccine The controversial issue of vaccines and autism risk This is the last episode of the season. Stay tuned for a Season Three preview in the next few weeks. We will have an exciting new topic, and Dr. Amy will collaborate with a dear friend and colleague, so stay tuned! Over the summer, the blog will carry on at Genetic Rockstars is in full swing at We are enrolling for a fall beta test version of MTHFR for life - I'll be asking for feedback for the beta version and in exchange, participants will get 75% off the regular price and loads more one-on-one contact with me. Enroll now to save your spot for a start after the labor day weekend.
July 24, 2022
S2E44: Natural skincare for chemically sensitive MTHFR folks with Renee Harris
Living the MTHFR lifestyle means reducing as much toxic exposure as possible and a lot of that comes through skincare. Today, Dr. Amy is talking with Renee Harris, founder of MadeOn skincare.  You can find Renee's products at For the complete show notes, click here. To watch the full, 30 minute interview, click here. To meet other folks with MTHFR polymorphisms and get a ton of great tips about living the MTHFR lifestyle, click here.
July 17, 2022
S2E42: Emotional Eating - an Interview with Tricia Nelson
Tricia Nelson is an emotional eating expert and the author of Heal Your Hunger: 7 Simple Steps to End Emotional Eating.  I am delighted to have the opportunity to talk with her because emotional eating, while it might sound like a departure for me, is a common problem among us MTHFR folks.   Anyone with MTHFR, COMT fast, or MAO-A fast can be more susceptible than average to emotional eating because emotional eating typically stems from low dopamine or low serotonin. Emotional eating falls within the realm of addictive behaviors and so it can be an MTHFR issue. The full interview is roughly 30 minutes and well worth a watch - check it out in the show notes here.  To visit Tricia Nelson's website or schedule a consultation with her, please go to To join a community of other MTHFR folks who might be struggling with similar issues, click here for Genetic Rockstars.
July 10, 2022
S2E42: PEMT, Every Cell In Your Body, and MTHFR
If I had to pick one mutation that was AS pivotal as MTHFR is, it would be PEMT. This mutation affects literally EVERY cell in your body - all 37.2 trillion of them. We'll talk about: The one well studied polymorphism (and the legions of other ones) Signs and symptoms that may point to a PEMT problam How to ease the burden on your PEMT And why it's important to love your liver. Enrollment for the Beta group of MTHFR for Life is now open and it's 75% off the usual price. We'll get started on July 11th and spots are limited for the Beta group so enroll now. For the complete show notes, click here. To join Genetic Rockstars, click here.
July 03, 2022
S2E41: MAO-A Fast and the Carbohydrate Rollercoaster
This week we'll talk about another gene SNP picture that is called MAO-A Fast. Having a fast MAO-A means you break down neurotransmitters faster than average, and since this gene SNP breaks down Serotonin, Melatonin, Norepinephrine, and Epinephrine you can imagine it leads to quite a lot of self-medication, and the easiest way to self-medicate is with Carbs. So we'll talk about: What is happening when you reach for the sugary and starchy carbs How to get off of the carbohydrate rollercoaster What diet is best for you Other things you can do to support healthier neurotransmitter levels. For the complete show notes, click here. To sign up for the Beta group of MTHFR For Life click here. For Genetic Rockstars, click here.
June 26, 2022
S2E40: MAO-A Slow And The Short Fuse
MAO-A is another gene SNP that is different from the others we've talked about because it is actually linked to a sex chromosome. The various SNPs add up to produce a "fast" or "slow" picture. We'll discuss: Why we can't tell women's MAO-A picture from a genetic report What symptoms to watch for that might indicate you have an MAO-A Slow picture How to manage slow MAO-A naturally Foods to enhance and avoid for slow MAO-A If you'd like to take a look at the complete show notes, they're here. To join the amazing community, Genetic Rockstars, click here. If you want to take a FREE MTHFR Basics course, click here.
June 19, 2022
S2E39: Vitamin D, VDR, and MTHFR.
Vitamin D doesn't link into the methylation cycle, the folate cycle, or even the BH4 pathway so it seems highly unrelated to MTHFR, but is that true? This week we'll explore: Why vitamin D seems to do literally everything in the research The gene SNPs that affect vitamin D Why folate and vitamin D have relationship status "complicated" How folate and vitamin D might have influenced skin pigment in evolution An MTHFR superpower that regards, you guessed it, vitamin D. For the complete show notes, click here. If you want to join the MTHFR community Genetic Rockstars, click here. If you want to take an MTHFR course or get on the list for future courses, click here.
June 12, 2022
S2E38: Is Low Histamine Actually a Problem?
Low histamine isn't something that doctors are talking about yet. It hasn't even really made it to the internet, which is usually first to know everything. But I think there might be more to low histamine states than meets the eye, so let's talk about it. We'll cover: Emerging research on cancer, cardiac disease, and Alzheimer's disease with low histamine Signs and symptoms of low histamine The Over-methylator/Black sheep basic state tie-in Four natural ways to boost your histamine if it's down. To read the complete show notes with links to research, click here. To become a Genetic Rockstar and join an amazing community of MTHFR folks getting better together, click here. To check out MTHFR courses including a free MTHFR Basics course, click here.
June 05, 2022
S2E37: High Histamine, MTHFR, and other Gene SNPs.
Histamine and MTHFR are joined together in so many ways. Let's talk about: The surprising things other than allergies that histamine influences. Risks and symptoms of high histamine Seven things you can do to lower your histamine naturally. For the complete show notes, click here.  To join Genetic Rockstars - the most incredibly community of MTHFR folks on the internet, click here. To take the free MTHFR Basics course or get on the list to be a beta tester for MTHFR for life, click here.
May 29, 2022
Arsenic, Mercury, and Fibromyalgia. Questions from Listeners.
I love listener questions because it's always something good! This week, we talk about: Detoxifying Arsenic Mercury toxicity with adrenal fatigue and MTHFR Amy's quick and dirty about fibromyalgia. If you're looking for this week's show notes, they're here. If you'd like to join Genetic Rockstars you can do that here, and if you want to ask you own question for me to answer on the air, scroll down to the video ask here. If you want to join the FREE MTHFR Basics course, you can do that here.
May 15, 2022
S2E35: Nitric Oxide, MTHFR, and the NOS3 gene SNP.
MTHFR is closely tied to heart disease, and nitric oxide (not to be confused with nitrous oxide, or laughing gas) is a big part of the reason why. In this episode we'll talk about: How nitric oxide is linked to heart attacks, strokes, alzheimers, sinus health, mouth breathing, and even some birth defects. Why humming matters How the NOS3 gene affects you and how it interacts with MTHFR How you can boost your nitric oxide production - with or without these genes. For the complete show notes, click here.  If you want to be a Genetic Rockstar and join the MTHFR community, click here. If you heard be talk about the FREE MTHFR Basics course and want in, click here.
May 08, 2022
S2E34: B12, MTR, and MTRR
Of course B12 is important to methylation and MTHFR, but why is that precisely? Well, spoiler alert - it has something to do with two different genes that are also involved in the methionine pathway - MTR and MTRR. So this week, let's talk about: Which gene creates especially difficult to treat issues with homocysteine (especially in combo with MTHFR). What to do about MTR and MTRR polymorphisms Why I talk about MTHFR so damn much How to get on the beta list for a teachable course this summer. you can click here for the complete show notes, and here if you really want to be a Genetic Rockstar.
May 01, 2022
S2E33: GST and GPX - Two Gene SNPs That Mess With Glutathione
We've talked about glutathione before, but now let's talk about two gene SNPs that really mess with your glutathione functioning. We'll discuss: Signs and symptoms of a GST polymorphism Signs and symptoms of a GPX polymoprhism Which SNP is linked to diabetes and early grey hair Which SNP makes walking through the perfume department a nightmare What you can do to help your body get stronger and healthier with either of these gene SNPs The complete show notes with links to other shows and episodes about glutathione are here. If you want to join Genetic Rockstars, you can do that here. To sign up for the mailing list so you get fresh info every week, click here.
April 24, 2022
S2E32: Glutathione Basics
We've talked about glutathione before, but let's review before we dive into gene SNPs that affect glutathione. We'll cover: The most common fatal overdose globally (that glutathione can help prevent) The heavy metal that needs glutathione to be taken out of your brain Why glutathione is called the "master antioxidant" Natural ways to boost glutathione Two surprisingly under researched gene SNPs affecting glutathione production. Don't forget to subscribe so you don't  miss the next episode which will cover two well-researched gene SNPs affecting glutathione. The complete show notes can be found here, genetic rockstars can be found here and you can sign up for a mailing list here.
April 17, 2022
S2E31: COMT Fast
With a COMT Fast picture we see an overly-efficient enzyme that gets rid of crucial substances before they have the chance to act. We'll talk about: The signs and symptoms of a laid-back fast COMT person. Why COMT fast folks absolutely shine in stressful situations. Some COMT fast superpowers. How you can balance your COMT fast for maximum health, happiness, and focus. For the complete show notes with links to resources about Seed cycling, click here.  For less than the price of one fancy coffee per month, you can become a Genetic Rockstar right here. Don't forget to sign up for the email list at to be the first to know about upcoming courses and offerings.
April 10, 2022
S2E30: COMT Slow
The COMT slow picture affects neurotransmitters, stress hormones, and estrogen. This week we'll talk about: Signs and symptoms of a slow COMT. How MTHFR ties into the mix. The superpowers that come with a slow COMT Four steps to balancing your COMT picture. Thanks for listening today. For the complete show notes, including links to research, click here. If you want to join the amazing community of people getting better together called Genetic Rockstars, click here. To sign up for the mailing list and get your free symptom tracker, click here.
April 03, 2022
To kick off our series about other genetic polymorphisms, we're starting with a heavy hitter called COMT. This week we'll talk about: What COMT means, what it does, and why that "M" is so important for MTHFR folks. Why theoretical math on a genetic report might not be as important as your symptoms and personality. What neurotransmitters, hormones, foods, and supplements are affected by this gene SNP. Why geneticists should never be in charge of naming babies. Thanks so much for listening. The complete show notes here here. Definitely sign up for Genetic Rockstars, our amazing community of people working on their gene SNPS or for the mailing list at because you're going to want to know when the 6 Weeks to Amazing with MTHFR course launches.
March 27, 2022
S2E28: Other Gene SNPs with MTHFR
MTHFR is not the only gene SNP out there - I know, you'd never know that if you listen to this podcast. So let's start a mini-series about other polymorphisms, but first we need to talk about the perils of deep diving into a genetic report. Genes are not very linear, but then what are they and how can we talk about them in a way that makes sense? There is one really big thing that matters a lot more than what gene SNPs are on your genetic report, do you know what it is? Do you know how to work with your genetics if you've never had a genetic report done? Let's discuss this and more. You can find the complete show notes here with links to references and supporting material. You can join an amazing group of MTHFR folks right here in Genetic Rockstars and you can find out more about one-on-one consults with me (Amy) here.
March 20, 2022
S2E27: What Is Really Going On With MTHFR Basic State?
MTHFR Basic States are an idea that generates a lot of controversy. Some well-respected practitioners don't like to use the idea at all, and some do. So let's talk through Basic States and I'll tell you why I think Basic States are a great concept that is really useful when you're working with MTHFR. We'll talk about Where the idea of basic states came from Why I don't like the terms "undermethylation" and "overmethylation" The risks of paying attention to gene SNPs but not basic state - especially when you aren't working with a practitioner. Thanks so much for listening today. If you'd like to see the complete show notes, click here. If you'd like to join the mailing list, click here and if you want to be a Genetic Rockstar, click here.
March 13, 2022
S2E26: Supplements for Depression with MTHFR
We've talked about so many facets of depression with MTHFR - including the link between MTHFR and neurotransmitter formation, overlooked causes of depression, the mental bad-habit factor, and what to do about those things. What we haven't talked about, are supplements that are MTHFR-safe and also effective. Let's look at three of my favorites. This week we'll talk about: Saffron NAC Rhodiola We'll go over the best times to take them, common doses used in research, and possible mechanisms of action. Don't forget to sign up for the mailing list at so that you are the first to know about exciting upcoming courses and changes to offerings. Also, if you're working your way through a healing journey with MTHFR, join Genetic Rockstars today - it's an amazing community of MTHFR folks who are helping each other get better.
February 27, 2022
S2E25: MTHFR Questions From Listeners - Products and Marmite.
Listeners Liana and Tim asked a couple of great questions this week so let's dive into them. Liana asks about specific product suggestions for 5-LMTHF - we'll talk about what to look for, a few of my personal favorites, and companies that I trust. Tim asks about whether there is or isn't folic acid in Marmite and this sent me down a rabbit hole of questions, so we'll talk through the somewhat ambiguous information that is out there on nutritional labels, and what to do with that. Also, how afraid do we need to be of added folic acid? I'll also dive into another great yeast-based food, which is nutritional yeast and what you need to look for there. Thanks so much for listening today and please make sure you're on the email list here because we've got some great programs coming up. Also, if you're interested in the MTHFR community Genetic Rockstars, click here. For the complete show notes with pictures of conflicting nutritional information on marmite and different types of nutritional yeast, click here. 
February 20, 2022
S2E24: Checking In with Your Progress With MTHFR
We haven't touched base about what is happening for you right now with MTHFR, so today is the day. Let's talk: Why we don't need to be changing things constantly What is happening in the background right now The foundational things we need to keep doing through this whole healing journey How often to check in with ourselves How to optimize your dose of methylation drivers We have some amazing stuff happening behind the scenes so make sure you join our mailing list at or join Genetic Rockstars, our MTHFR community so that you're the first to know.  Also, the complete show notes can be found here.
February 14, 2022
S2E23: The Risks of UMFA in Pregnancy
Last week we talked about the remarkable results 5-LMTHF produced in couples struggling with infertility relative to high-dose folic acid, which is the standard of care.  This week, let's expand on that by looking at some possible risks of high-dose folic acid to those very same pregnancies. First, let's talk about the actual difference to blood levels between high and low dose pregnant women. Then, a study linking UMFA in certain groups with risks of ASD or autism spectrum disorder. Lastly, a study showing an interesting link between UMFA levels and food allergies. While the research on UMFA in pregnancy is in early days, it still brings up some compelling points to share with your team of practitioners during pregnancy to make sure that you are getting the best supplementation for you. If you'd like to read the complete show notes with research, click here. To take a closer look at the MTHFR community Genetic Rockstars, click here. To sign up for the mailing list, go to the website here.
February 06, 2022
S2E22: The Harm that 5000 mcg Folic Acid Can Do To Fertility with MTHFR
5000 mcg folic acid is the standard of care for pregnancies that are considered high-risk and pregnancies in couples struggling with infertility. Unfortunately, many of those couples have MTHFR polymorphisms in one or both partners, and for anybody with MTHFR issues, this is going to actually impair the fertility process and damage their health.  We'll talk about one particular research study that followed 33 couples with MTHFR polymorphisms who used the simple addition of 5-LMTHF to drastically change their successful pregnancy rates. For the complete show notes including a link to the full study that you can take to your midwife or fertility center, click here. To join the amazing MTHFR community Genetic Rockstars, click here. To sign up for the email list so you're the first to know about upcoming courses, click here.
January 30, 2022
Supplements for Anxiety with or without MTHFR
I'm hoping it goes without saying that balancing your methylation is the first step you should consider taking with anxiety, with or without a known MTHFR mutation. But after that, there might be some pieces you still need to clean up with supplements and that's where these three suggestions come in. We'll discuss: GABA - a neurotransmitter that shows great results for long-term anxiety coverage An herb that has great research for short and long term anxiety  and is equivalent in effects to a common benzodiazepine A category of botanical medicines that genuinely help your body adapt gracefully to every kind of stressor.  Sign up for the weekly newsletter at, or join us in the MTHFR community Genetic Rockstars. Also, look out for new courses and offerings for MTHFR folks coming up this year.
January 23, 2022
S2E20: MTHFR and Anxiety - An Interview with Jennifer Bronsnick
MTHFR and Anxiety can go hand in hand, so let's hear from anxiety expert Jennifer Bronsnick about her own anxiety journey and some of the tools she has found useful for herself and her clients. We'll talk about alcohol, sugars, heart math, and more. The full interview can be found in video format here. To join Genetic Rockstars or the MTHFR Academy, click here.
January 16, 2022
S2E19: MTHFR and Anxiety
MTHFR and anxiety are intimately linked, as we have explored in other episodes. Please visit the full show notes here if you'd like links to those episodes. This week we'll discuss: The thing that sounds like it's too simple to make a difference, but does. Some common medications that may be contributing to your anxiety. The links between your morning coffee, your menstrual cycle (if you happen to have one) and anxiety. Some tips to make exercise, yoga, and meditation more effective. If you haven't done so already, please sign up for the mailing list at To Health With That! so that you're the first to know about exciting things coming your way. Also, check out genetic rockstars, the amazing MTHFR community, here.
January 09, 2022
S2E18: The MTHFR Lifestyle
I mention it a *lot* but what is the MTHFR Lifestyle? Here is your chance to find out. We'll discuss what a good lifestyle really means and why we have the perfect excuse to cultivate one. We'll also address the myth of perfection. For the complete show notes, click here. To sign up for the mailing list, click here. To check out genetic rockstars or the MTHFR Academy, click here.
January 02, 2022
S2E17: Happy Holidays and New Years Resolutions
Let's face it, 2021 has been difficult for a lot of us. Let's make 2022 a year with more joy, more happiness, and more ease. Thank you so much for being a part of this journey and for spending your time with me - it means more to me than you'll ever know. With love from Amy.
December 26, 2021
Hydration Matters for MTHFR
Water is so talked about that it has become a non-answer for everything. Nobody pays attention because it's just too simple. Well, let's talk about the thing people fail to mention, which is hydration. It isn't how much water you drink or even absorb that matters, it's how much gets into your cells. In this episode we'll: Review the terribly boring high school chemistry experiment that explains this whole thing. Go over five hydration hacks to plump up your cells nicely. Give you the skinny on sports drinks. Thanks so much for listening today and stay safe. If you'd like to read the complete show notes, click here. To learn more about seeing Amy one-on-one, click here. If you're interested in becoming a Genetic Rockstar or joining the MTHFR Academy, click here.
December 19, 2021
S2E15: What To Do When You're Having Detox Symptoms
Detox symptoms are a thing that happens to us. Hopefully, two weeks ago you started thinking about how to recognize them.  Now, let's discuss the two big strategies for doing this. Give your body less to do that day. Make it easier for your body to actually eliminate toxins. It makes sense when you look at it, but let's dive into a few strategies. For the complete show notes, click here.  If you'd like to schedule a one-on-one coaching call with Amy, click here.  If you want to join our MTHFR community, Genetic Rockstars, click here.
December 12, 2021
S2E13: Patterns in Symptom Tracking
I know - I can hear you rolling your eyes, but symptom tracking makes a huge difference, so let's talk about it a little bit more. This week we'll discuss: The five patterns you should watch for with MTHFR Why patterns matter Why it helps to recognize your own patterns to begin with. The complete show notes can be found here, if you'd like to join the most amazing community of MTHFR folks on the internet, Genetic Rockstars is here, and if you're interested in the Patreon-only podcast, MTHFR Stories, it's here.
November 28, 2021
S2E12: Week One of Methylfolate and a Bit About Backlog
Congratulations! If you've been following along with the show, then you're one week into your 5-LMTHF start.  It may have been a great success, you might have hit a dealbreaker, but either way we'll talk about it. This week we'll discuss: The four scenarios you might have encountered in your 5-LMTHF start What to do in each case Why no matter how you've reacted, we're not changing dose for at least 3-4 weeks What new phase you're entering now. For the complete show notes with links to the resources I talk about, click here or go to  If you're interesting in the amazing MTHFR community, Genetic Rockstars, click here. If you feel like you're getting good info from this show and would like to support it in some way, visit me on Patreon at - there is even a Patron only podcast called MTHFR Stories that is so worth it.
November 21, 2021
S2E11: The Methylfolate Start
Finally, we're here! It's what we've all been waiting for. So let's talk about: Dealbreaker scenarios to watch for that mean you  might not tolerate methylfolate at all Normal scenarios that might still feel a little strange Ways to manage symptoms, if you have any Why you might be having symptoms to begin with. If you'd like to see the full show notes with links to helpful information, they're here. To join us in Genetic Rockstars, click here and to check out the new Patreon page, click here.
November 14, 2021
S2E10: Why Starting 5-LMTHF Can Cause Symptoms
Normally, starting a supplement is a piece of cake, but that isn't always the case with 5-LMTHF. But why is this one so different? This week we'll talk about: The three big categories of things that are changing that can cause symptoms Why I take things so damn slow Why sometimes changing your methylation is like rolling a tire down a bumpy hill Thanks for listening today! If you want to see the complete show notes, they're here.  If you are a Genetic Rockstar (or want to be) click here. If you like the show and have the means to contribute, you can add to the show here on Patreon. 
November 07, 2021
S2E9: MTHFR Listener Questions Oct. 2021
You've got questions and I've got answers, or at least theories. This week we'll talk about: What type of blood testing should MTHFR folks be doing regularly? A kiddo with ADHD and MTHFR who is resistant to most meds.  Where do we go next? I'm taking methylfolate but adding other B vitamins makes me mean and hateful. What should I do now? My folate levels dropped after starting active folate and Metanx. Why? I love listener questions and if you have a question, I'd be so delighted to answer it on the show! You can leave questions for me in the video ask at You can also leave questions for me in Genetic Rockstars (and get input from people who have been in your shoes as well). For the show notes and written version of what we talked about today, you can go here.
October 31, 2021
S2E8: The Preliminaries with MTHFR
The MTHFR journey happens in three phases and the one we're in I like to call the Preliminaries. This is where we prime your system for the big flood of methylated goodness that is about to come in. We're greasing the wheels, so to speak. This week we'll talk about: What you should be doing right now to get your body ready. What you shouldn't be doing (even though you want to). The three phases of your progression through MTHFR If you're looking for the show notes, you can find them here. If you'd like to become a Genetic Rockstar or join the MTHFR Academy you can do that here, and to visit my newly created Patreon page and support the show, visit Thanks so much!
October 24, 2021
S2E7: B12 and MTHFR
Most B vitamins are great with MTHFR. No big issues and they generally make us feel better.  There is one, however, that is a bit tricky and that is vitamin B12. In this episode we'll talk about: Which form of B12 is most likely to cause symptoms Why being bonded to cyanide isn't actually a huge deal The form of B12 that is showing the most promise for people with chronic fatigue syndrome (or ME/CFS as they're calling it now). Which form of vitamin B12 is almost like a sustained release. If you're looking for the show notes, you can find them here.  If you're looking for the MTHFR community, Genetic Rockstars, it's here, and if you're looking for my brand spanking new Patreon page, that one is found here at Thanks for listening!
October 17, 2021
S2E6: The Other B Vitamins for MTHFR
Sure, "folate" is in the name of this mutation, but the most common mistake I see MTHFR folks make is thinking that it's all about folate. This episode we'll talk about: How the MTHFR enzyme is like lead-to-gold alchemy What other B vitamin makes the magic happen Why there are no "C vitamins" or "D vitamins" but there are "B vitamins" Also, I am starting a Patreon page, which isn't quite live yet but it will be! When it is live, you'll be able to find it at you can find the show notes here, and if you'd like to join Genetic Rockstars, you can do that here.
October 10, 2021
S2E5: Patience on the MTHFR Journey
Patience is thin on the ground for MTHFR folks, which is ironic, because it's the thing we need most on our path to health. This week we'll talk about: How healing is like a boardwalk through a crocodile infested swamp Why both sides of the MTHFR coin are generally terrible at patience More about the differences between overmethylators and undermethylators Three reasons why patience really does matter. Sigh. Thanks so much for listening and in exciting news, I'm launching a Patreon page for anyone out there who feels like they're getting something out of this show and want to help me keep making it. It should be live next week!  For the complete show notes including links to relevant past shows, you can click here.  If you want to join an amazing community of MTHFR folks, click here.
October 03, 2021
S2E4: Adding High Folate Foods
We are moving through the very baby beginnings of the MTHFR journey. Before you add in any fancy supplements or methylation boosters, we're going to take the much less fancy but far more effective step of adding natural folate into your diet. We'll talk about: The best and easiest food sources of natural folate Why Tex Mex is possibly the best food ever A good condiment you can add in to boost your folate fast. If you'd like to see the show notes with far more detail about particular foods, click here. And, you can check out an amazing community of MTHFR folks here.
September 26, 2021
S2E3: MTHFR and Food Cravings
Food cravings can have a hidden wisdom and some of you may have noticed some of them coming up if you've just eliminated the folic acid foods from your diet. Let's discuss! This week we'll cover: The three types of cravings and why each has value Which type can (or can't) be found at the bottom of a bag of chips Shocking research linking the similarities between certain food cravings and opioid addiction. Why this could be relevant for you right now. Thanks for listening and as always, the show notes contain links to great research and related resources and can be seen here. If you'd like more of this, I would love to meet you in Genetic Rockstars, our MTHFR community.
September 19, 2021
S2E2: Getting Toxic Folic Acid, Out.
In typical Amy fashion, this week I'm doing my best to scare all of you dear listeners away by giving you the hardest possible task up front: getting the folic acid out of your diet. We'll talk about: Why I'm asking you to do this when it will surely cause you to dislike me intensely Why folic acid is in food anyway Why this well-intentioned enrichment doesn't work for some people (and who those people are) What to eat if you aren't eating fortified foods Thanks for hanging in there with me! If you want to see the complete show notes, they're here.  If you'd like to join me in methylfolate masterclass, do so quickly here. If you'd love to join the tribe in Genetic Rockstars or the MTHFR Academy and talk to other people who are taking folic acid out of their diets you can do that here.
September 12, 2021
S2E1: Preparing to Get Healthy With MTHFR
Welcome back to To Health With That! Season two is going to be a typical MTHFR journey, step by step. We will walk through the entire process of working on your own MTHFR, naturally. If you happen to remember the movie Office Space, this week, we're "planning to plan." We're laying the foundation for the rest of the journey with three things: A symptom tracker A pantry overhaul and some serious carbo-loading A talk with your spouse, friends, and possibly your pet hamster. These are the foundations without which the whole show can go off the rails really easily, so listen today to find out more. You can find the complete show notes here and if you're interested in Genetic Rockstars, our community of amazing MTHFR folks, you can find us here.
September 07, 2021
Season 2 Preview.
Season One has been amazing. So much information from a very academic standpoint, but what about practical application? I want you to enjoy a beautiful, sultry, summery August and come back in September for a year in the life of MTHFR. We'll literally take the journey one week at a time so you can follow along, learn more about why some thing helps and some things don't, and actually get better along the way. Here are just a few of the things we'll talk about: Prepping for your MTHFR journey Taking a long, hard look at your pantry (eek!) Why the first step is NOT 5-LMTHF What to do when you hit a wall What your body is really saying when you feel... x Dealing with the most common MTHFR-related problems (estrogen dominance, high homocysteine, mental health, distractibility, etc...) We'll walk through all of this together. Coming, September 5th.
August 01, 2021
Empty Bucket, Fix Backlog
This sounds like the MTHFR version of a Zen slogan... Chop wood, carry water.  Empty bucket, fix backlog. It could easily be the mantra we live by. In this episode we'll cover: What exactly is in that bucket How much of it is fixable by you All the things you aren't aware of in your bucket and backlog Where the baggage of backlog comes from How you can begin to address it. Amy and the To Health With That podcast will be taking a break for August, but we'll be back in September with Season 2, which will be all about working with your MTHFR on a day to day basis in step-by-step practical format. I can't wait!  If you're looking for the show notes, they're here and if you want to join the MTHFR Academy and fast-track your MTHFR journey with Amy, you can do that here or go to
July 25, 2021
Why Does My Methylfolate Dose Change So Much?
MTHFR can be a strange and wonderful journey, and the only real constant is change.  But why? Why do doses change so much? This week, we'll talk about: The typical dosage changes you can expect on your MTHFR journey What is behind a sudden need for more 5-LMTHF Why the dose you've been taking for years might suddenly be too much What is happening in your body behind the scenes IF you have any questions, you can leave them for me here, check out the show notes here, or best yet, join the MTHFR Academy if you're really serious about your health goals and I will answer this and every other question you have there.
July 18, 2021
What Causes Bad Days? The Bucket and The Backlog
When you're working with MTHFR and following a good plan, you start to feel better from day one. But that doesn't mean that day 38 isn't kind of icky. There are bad days and that's part of the journey, but why? What is really happening when these bad days jump out at you? We'll talk about: Your bucket Your backlog Working with both of those Some tools you can use to fix bad days. Why symptom tracking makes all the difference. If you want a free symptom tracker, sign up for my newsletter here for a free download, or join the MTHFR community Genetic Rockstars and find your free symptom tracker in the MTHFR Library - a whole bunch of free resources just for the community.
July 11, 2021
How Do You Know When Your Methylation Is Balanced With MTHFR?
This is a big journey - how do you know when you're there? In good news, there are two main ways. This week, we'll talk about: Signs and behaviors that indicate your methylation is balanced What to do if you need a more concrete answer Three lab values that matter A few lab values that don't matter so much (in my opinion). The most important thing is to let the journey happen. You can't really rush this one! I'd love to see you in the free MTHFR community Genetic Rockstars, or even, if you want a little bit more support, in MTHFR Academy - a dedicated MTHFR coaching community.
July 04, 2021
MTHFR Questions From Listeners
This week we've got some questions from listeners - all about MTHFR. We'll talk about: What to do if you want to work with Amy. The three different options and how to find them. How MRI Contrast medium might be different for MTHFR folks What mamas nursing MTHFR babies should do about MRIs How to ask a question of your own. I'll try to do answer sessions once a month. If you do have a question, go to and scroll down the page about half way. You'll se a video of me, asking you for your questions. You can ask your question in video, audio, or written format. Thanks so much to Sandy and Sam, who asked this week's questions. If you're interesting in joining Genetic Rockstars, our amazing MTHFR community, go to
June 27, 2021
MTHFR and Joyhacks - Simple Steps to Boost Your Happy.
We've all heard so many  things we're supposed to do to be happy, but do you know anybody who actually does them? This week we'll talk about simple joyhacks, most of which take five minutes or less, that have been shown by science to boost your happiness. We'll talk about: A two-minute trick with a pencil (no joke!) Why smaller, achievable goals boost your joy more than bigger, shinier ones. A great reason to visit an art gallery, take a hike, or play in the park. Why the little stuff matters more than the big stuff. I hope you'll join us in Genetic Rockstars because, IMHO it's the most amazing group of MTHFR folks on the internet. Hear other people's stories, share laughs, take a course like the 10-week MTHFR 101, or even join group coaching in the MTHFR Academy. It's all waiting for you at
June 20, 2021
MTHFR and Neurotransmitters - Amy's Neurotransmitter Theory
Research has mostly shown that mental health issues often correlate with imbalance in neurotransmitters and so that idea has been locked in socially. We have painted ourselves into a corner in which ALL mental health issues must be neurotransmitters. This week, we'll talk about: Four reasons why it might not always be about neurotransmitters. Why the word "depression" might mean something different to everybody. How the mechanistic model fails in neurotransmitter balance. Amy's theory on neurotransmitters. This week you can see the complete show notes here, and you can check out our amazing MTHFR community, Genetic Rockstars, here.
June 13, 2021
MTHFR and Norepinephrine
One more episode in our mini-series on neurotransmitters, MTHFR also affects your levels of norepinephrine and its metabolite, epinephrine. We'll discuss: The only two neurotransmitters that are also hormones and what that means. Why too high norepinephrine looks like you've taken too much cocaine. The sloth of too low norepinephrine. A few simple things you can do to boost or quench your norepinephrine and epinephrine. If you'd like to see the full show notes you can find those here.  Also, I'd love it if you'd join me in the MTHFR community, Genetic Rockstars.
June 06, 2021
MTHFR and Dopamine
In our little mini-series on MTHFR and neurotransmitters, we'll move on to discuss the relationship between MTHFR and dopamine. We'll talk about: The unlikely first symptoms you might see of low dopamine levels Why banana smoothies might help with dopamine related weight gain (like after you quit smoking) The issue with dopamine receptors And how to boost your levels without drugs. For the complete show notes including links to related concepts (like our post on serotonin, or the BH4 connection) you can click here. If you can't wait to join the MTHFR community, Genetic Rockstars, or take an MTHFR 101 course, click here. Thanks for listening! Don't forget to subscribe or leave a review so other people can find great information to help them on their MTHFR journey a little bit more easily.
May 30, 2021
Neurotransmitters: Serotonin and MTHFR
MTHFR is tangled up with neurotransmitters via its direct link with the BH4 pathway, which is where most neurotransmitters are made. So let's talk about MTHFR and serotonin. This week we'll go over: The surprisingly mixed evidence with serotonin and depression. The first thing you should do to boost serotonin with MTHFR. Low serotonin symptoms you might never think of. Some amazing serotonin boosters that are all natural. Thanks for listening today and if you'd like the complete show notes with links to resources, they're here.  Also, if you want to be a Genetic Rockstar too, click here.
May 23, 2021
MTHFR and Decision Fatigue
Decision fatigue is the weary, burned out feeling that comes from the constant burden of too many choices. Simple choices and consequential ones all add into this issue, but today we're talking about some strategies especially for the decision fatigue that comes along with MTHFR and any other chronic health issue. We'll discuss: 4 red flags that tell you you're in decision fatigue territory. 7 ways to minimize decision fatigue in your health or any other area of your life right now. How the 80-20 rule can simplify your life. Thanks for listening and if you're looking for the complete show notes, click here.  If you know or suspect you have an MTHFR issue and want to join an amazing community of people who are getting better together, join Genetic Rockstars today at
May 16, 2021
The Best B12 for MTHFR Mutants
This is our most frequently asked question in Genetic Rockstars, the MTHFR community, so I figured we'd better have a conversation about it. This week we'll discuss: The four most common forms of B12 available Which forms are active Which form is already methylated The form that can have the most side effects for MTHFR folks The form that needs to be detoxified as well as methylated. B 12 is pivotal to the MTHFR journey, so it helps to know your stuff before you buy. You can see the full show notes here, and if you're pretty sure you should be a Genetic Rockstar (because I'm pretty sure you need to be,) click here.
May 09, 2021
Omega-3 Fatty Acids and Gene Expression in MTHFR
These two amazing research studies are actually measuring how active the MTHFR gene is and how Omega-3 fatty acids from fish oils change that. We'll talk about: B vitamins and omega-3s together and what happens to homocysteine when you take them. The remarkable effects of omega-3 for pregnant women with MTHFR. Why EVERY pregnant woman with MTHFR should take fish oils. Thanks for listening and if you want to see the full show notes or diagrams of how the different enzymes fit into the homocysteine cycle, they're here.
May 02, 2021
The Magical Relationship Between B Vitamins and Fish Oils
Research is starting to show that some magic happens between B vitamins and fish oils, or omega-3 fatty acids, that allows the two of them together to work far better than either one alone.  Especially in areas that are of some concern to MTHFR folks, like cognitive decline, homocysteine levels, and inflammation. What is the magic here? You can check out the full show notes here: MTHFR, B Vitamins and Fish Oils. Also, check out our amazing community of MTHFR folks just like you, here at Genetic Rockstars.
April 25, 2021
Lowering Your Homocysteine With MTHFR
We've talked about the risks of homocysteine and optimal  levels and even the link between Covid-19 disease severity and Homocysteine, so now, let's talk about how to tackle the problem when your homocysteine is high. Let's learn about: Why it's important to remember you can have fleas and ticks on the same dog. Other causes of high homocysteine A step-by-step plan to get your homocysteine levels into optimal. Thanks for  listening this week! If you'd like to see the full show notes, they are here. Also, a huge shoutout to all of the people who have joined me in the Genetic Rockstars MTHFR Community - I can't believe how amazing everyone is.
April 18, 2021
Homocysteine By The Numbers
Ok - so we get that homocysteine is a problem for MTHFR folks. But what levels are we talking about here? In this episode we'll talk about: Important things your doctor might forget to tell you when you're getting your homocysteine tested. The normal range, and why in this case "normal" has little to do with optimal. What the research is beginning to show might be a more ideal range to shoot for. The unexpected risks of lowering your homocysteine too much. We'll also talk a bit about Genetic Rockstars, our new MTHFR community full of incredible folks - I hope you join us there at  You can click here for the complete show notes.
April 11, 2021
MTHFR and Covid-19 - What We Know Now.
In good-ish news, Covid-19 has been around long enough for us to get some DNA-specific research into the mix. Not much research has been done yet on Covid-19 and MTHFR, but we do have some data. We'll talk about: The link between C677T mutation, Covid-19 and mortality rates How high homocysteine might be a predictor of Covid-19 outcomes Why MTHFR folks are more susceptible to acute viral-related high homocysteine How MTHFR folks can protect themselves from the worst Covid-19 outcomes Why avoiding folic acid is even more important than ever. Thanks for listening and come visit Genetic Rockstars, the MTHFR community at
April 05, 2021
Methionine, homocysteine, and MTHFR.
It's really easy to get into the mindset that methionine is "good" and homocysteine is "bad" but the truth is so much more interesting than that! Let's talk about: The nutrients you are probably getting way too much of if you live in the West. How "boosting your protein" might be a failed strategy. The weird link between methionine and Covid-19 Why MTHFR folks have to be extra careful about their protein intake. Don't miss the detailed show notes here with all the protein requirements and if you're as excited about Genetic Rockstars as I am, click to join.
March 28, 2021
MTHFR and Homocysteine - The Basics
Homocysteine is usually the first thing that tips you or your doctor off to the fact that there may be an MTHFR mutation or an issue somewhere else in this genetic process. But what is the big deal? In this episode we'll talk about: The risks of having high homocysteine - it's not just about your heart (but heart attacks are a real problem, so don't underestimate that part). The link between MTHFR, B vitamins, and homocysteine The reason why homocysteine is actually necessary for your health The great thing about using homocysteine as a tool. An announcement about Genetic Rockstars - you don't want to miss that! The complete show notes for this week with links to a *lot* of research, are here. 
March 21, 2021
Detox for MTHFR, Revisited
We've had a few conversations about detox, but let's revisit some of these concepts in greater detail. This week we'll talk about: The symptoms that can happen if you're pushing detox too hard. Why being emotionally "toxic" and physically toxic are eerily similar. Three lovely ways for MTHFR folks to detox without the drama and life-crises of detox kits. If you're looking for the complete show notes with links to research, here they are.  If you'd like to join the most amazing community of MTHFR folks on the internet, check out Genetic Rockstars.
March 14, 2021
What To Expect When You're Breaking Mental Bad Habits
Last week we talked about the idea of breaking mental bad habits and I gave you three tools you can use. The Fantasy The Stop and Drop The Distraction So what happens when you actually start using these tools? Find out in today's episode. You'll learn about: The four phases of progress Why step two is vital, but feels like you're moving backward The science behind what seems so good it could only be witchcraft For the full show notes, click here or visit
March 07, 2021
The Genius of Overmethylators
Let's talk about Overmethylation. Do overmethylators even need to have the MTHFR mutation? Unique gifts overmethylators bring to the world and the strengths of this group. The darker side of those gifts. Health risks that are more common in overmethylators. Drug and nutrient reactions that are more likely for the folks in this group. For the complete show notes, look here. If you're not sure if you're an undermethylator or an overmethylator look here. If you want to sign up for the beta group of my MTHFR 101 class - email me at Amy @ (but leave out the spaces.)
March 03, 2021
Mental Bad Habits
This week we're expanding on the conversation about other factors in depression and talking about the single most overlooked factor in mental health - bad habits. Mental bad habits are a fact of life, but we'll talk about three different techniques to break them. The fantasy The stop and drop The distraction We'll also talk about how these bad habits form to begin with and what neuroplasticity has to do with all of it.  Click here for the complete show notes and next week we'll finish the conversation with a little bit more on what to expect when you're starting to use these life hacks.
February 28, 2021
MTHFR and Depression
Depression isn't an MTHFR problem, it's a human problem. Having said that, there are lots of ways MTHFR can contribute and the best news is, they're mostly fixable. In this episode we'll talk about: The two contributors to depression that every parent of a toddler understands. How balancing your methylation can help reduce five potential contributors to depression. Why when your doctor "runs out of drugs to try," you still have a bunch of options. For the complete show notes (with links to buckets of research) click here.  If you want to join me in the beta group for an MTHFR 101 course, email me at amy at (except take out the spaces and replace the word "at" with the @ symbol.) 
February 21, 2021
The Genius of Undermethylators
Undermethylation is the most common MTHFR basic state, and it has its own unique strengths, challenges, and reactions to the world. In this episode you will learn: The amazing things about undermethylators that have helped them push their dreams into the world. The three most common health issues undermethylators face. Drugs and supplements to which  undermethylators tend to react badly. The link between undermethylation and histamine. For complete show notes, follow this link. If you're not sure if you're an overmethylator or an undermethylator, follow this link. If you're interested in being part of the beta group of MTHFR 101, email me at amy at (but without the spaces, and replacing the "at" with @).
February 14, 2021
Stages of Healing with MTHFR
Healing can be a messy process, but by using a systematic approach you can avoid some of the craziness. In this episode we'll talk about: Supplement Soup, and how to avoid it. The three phases for working with MTHFR The four piles you should put your supplements into (and which ones you can toss). The beta group for Amy's new MTHFR 101 course - launching this spring, and how you can be a part of it. The complete show notes can be seen here. Thanks for listening!
January 31, 2021
The Bucket Theory and MTHFR
This week will help you to get a mental image of how all of your tiny stressors end up turning into symptoms your body. It's an MTHFR fairy tale (don't worry, there's a happy ending.) Remember - the goal is to empty your bucket. :) The full show notes can be seen here:
January 24, 2021
MTHFR and Allergies or Sensitivities
Let's face it - MTHFR goes hand in hand with allergies and sensitivities in a number of different forms. In this episode, we'll talk about: The four known links between MTHFR and allergies. The four types of allergies or sensitivities that are common for MTHFR folks. How these sensitivities can be a strength, if you can harness them. For details about the upcoming MTHFR community, follow this link. And for the complete show notes with links to research, click here.
January 17, 2021
MTHFR and Pain Medications
This episode resulted from a great question from listener Jane Turner - thanks, Jane! We'll talk about: MTHFR and Tylenol (or paracetamol, or acetaminophen - just depending on what country you happen to be in) MTHFR and NSAIDS (or non-steroidal anti-inflammatories) Surprising information about MTHFR and aspirin The sad truth about MTHFR and opioid medications One commonly used anesthetic that is not a great idea for MTHFR folks A quick look at some alternatives for chronic pain Thanks for listening and you can find detailed show notes with links to the research, here.
January 10, 2021
A1298C Mutation
The internets get hugely focused on particular mutations, so here's my nod to A1298C. In this episode we'll talk about: What makes a difference in your clinical outcomes according to research and my own clinical practice What doesn't (that matters just as much!) The confusing nomenclature of A1298C and what it all means The one factor that is far more important than your particular mutation A superpower that might be specific to A1298C mutations - although it's anyone's guess why. If you're interested in seeing the show notes, they're right here.
December 20, 2020
All About C677T Mutation
This episode might surprise you! This week we'll go over: The bizarre and confusing array of names for the C677T mutation The gaps in current research How much you can trust the research regarding enzyme activity and level of compromise The two factors that actually matter about the mutation Which information reigns supreme, clinically speaking - your mutation or your basic over/undermethylation state. You can see the complete show notes and links to all of the research here. Don't forget to give me a thumbs up or a high-five or a bunch of stars or some kind of smiley face or four tomatoes or whatever it is I'm supposed to be getting. Help other mutants find some good info! :)
December 13, 2020
Gentle Detox Strategies for MTHFR Mutants
Detox is for life, at least it is if you, like me, have an MTHFR situation. In this episode we'll discuss: Why detox kits are not always the best for us (it isn't the answer you're expecting) Three strategies for ongoing gentle detoxification What a "gut sponge" actually is And the unsexiest detox topic. Thanks for listening and if you'd like to see the full show notes, you can click here. Don't forget to subscribe! Also, I totally busted 10 minutes this week, but I couldn't find anything to cut! Sorry folks, I'll do better next week. :)
December 06, 2020
What Is The Goal With MTHFR?
It's important to keep the goals in mind when you're working with MTHFR, but... what are they? We'll talk about: Three concrete health goals to work toward  The misguided idea of perfection A gentler view of the aims with MTHFR You can see the full show notes here, and sign up to the mailing list to get a free symptom tracker and some other free goodies at
November 29, 2020
What to Expect When You Start Methylfolate
Starting methylfolate can be a rocky road, so it helps to know what is a normal part of starting and what is a signal that something has gone wrong somewhere. In this episode we'll talk about: When ups and downs matter. Signs and symptoms that you're pushing detoxification too hard. Why detoxification is even involved in this. How to support your body through different scenarios. The complete show notes are here and keep your eyes and ears open for an upcoming course announcement!
November 22, 2020
Dosing Strategies for 5-LMTHF.
Dosing 5-LMTHF isn't typically just finding a right dose and sticking with it until you die.  Typically, you have to be able to roll with the punches. In this episode, we talk about three different dosing strategies.  My favorite, intuitive dosing, Dr. Ben Lynch's Pulse Method, and a mixed strategy. We'll discuss: The three things you actually do have to take regularly. Who might not do well with intuitive dosing. The best strategy for people who thrive on routine. For the full show notes, follow this link.  Don't forget to subscribe and leave feedback.
November 08, 2020
I Have MTHFR - How Do I Start Taking 5-LMTHF?
This is, of course, what everybody wants to know first thing out of the gate, before they do anything else with MTHFR, so let's talk about it. This week we'll discuss: The three things you should already be doing before you start 5-LMTHF. The three rules for starting any supplement effectively (but especially methylfolate) The three types of reactions you can expect with methylfolate What to do if you don't tolerate it. Be sure to sign up for the mailing list on our website because we're sending out lots of freebies with more information about the topics we cover. Also, you can see the full show notes here along with links to more information about other concepts we've discussed. Thanks!
November 01, 2020
Choline, Magnesium and Zinc for MTHFR
Of course MTHFR is about folate, but the whole methylation pathway is so vital to your health, that lots of other nutrients are tied up in this process, too. Today we'll discuss: What nutrient you absolutely must take if you've got non-alcoholic fatty liver disease (NAFLD), which is shockingly common in MTHFR folks. What food source of magnesium has convinced Amy that there is a God. How much the nutritional value of our food has declined in the last century (it's shocking. Absolutely shocking.) Which nutrient is especially important if you're making babies. For the complete show notes with links to research, see this page on Also, if you're new to MTHFR, check out our Start Here guide.
October 25, 2020
Knowing Your Own MTHFR Red Flags, And Whether You're Moving To Health or Disease.
The question of whether you're moving to health or disease is a silly one, right? Of course you know. Except with MTHFR, this might be tricker than you think. In this episode we'll talk about: Finding your own MTHFR red flags that are your early warning signs that you're going in the wrong direction. Why I (Amy, your host) am in love with symptom trackers. How to use a symptom tracker. The tricky MTHFR red flags that disguise themselves as "positive traits." The four types of signs and symptoms you should be tracking for MTHFR. I hope you enjoy and if you're looking for the show notes, click here.  Also, if you sign up for the mailing list you can download the free symptom tracker and a couple of other great freebies for MTHFR folks.
October 18, 2020
I Can't Take Folate - Now What?
Folate is supposed to cure what ails you with MTHFR, so what happens if you just don't tolerate it... at all? This is a problem lots of MTHFR folks face, so in this episode we'll cover: The most crucial step if you don't tolerate folate - changing this one thing can fix something that has probably been making you feel worse your whole life. Two cheat work-arounds when folate isn't an option The difference between folate and SSRI medications The main categories of MTHFR folks who just don't do well with folate -  not even natural folate in foods. You can see the full show notes here and access our Start Here for MTHFR page, here.
October 11, 2020
Your Basic State - Overmethylator, Undermethylator or Methylation Neutral
This is a topic of some debate among the MTHFR community, and one area where Dr. Ben Lynch and I have differing opinions. In this episode we will deep dive into: The ways your personality is shaped by your basic state. The archetypes of the basic states (are you the executive, the black sheep or somewhere in the middle?) Whether or not optimizing your methylation will change your essential personality and nature How to use your basic state as an in-the-moment sign of your methylation status Click here for the full show notes with helpful graphics, links to research, and and an over- vs. under- comparison chart. If you want to reach out and let me know what your basic state is, I'd love to hear from you. amy at Thanks!
October 04, 2020
Energy, Fatigue, and MTHFR.
MTHFR has its sticky fingers in almost everything and energy is no exception. Fatigue is one of the most common symptoms that MTHFR folks experience, but let's face it - it's one of the most common symptoms we all experience. In this episode we'll learn: The six factors that link fatigue and MTHFR Steps one, two and three to tackling fatigue Eight basic steps toward good sleep hygiene The best trifecta of sleep supplements Other factors to watch out for that might link in to low energy. Don't forget to subscribe, like, leave feedback, tweet, insta, or whatever you do - I'd love to hear from you! For the complete show notes including links to all the relevant research, click here.
September 28, 2020
MTHFR and Glutathione
Glutathione is called the "master antioxidant," which sounds important, so obviously the MTHFR polymorphism is going to mess it up. In this episode we'll talk about: Why glutathione is the antioxidant of antioxidants. What diseases are associated with low glutathione (more than half of which are also associated with MTHFR. Guess why!) How to boost your glutathione naturally and effectively What foods help increase glutathione When it is most important to think about glutathione supplements. You can click here for the full show notes and sign up for the mailing list at so you don't miss out on any freebies, give-aways or course announcements.
September 20, 2020
It's Not All About Folate and Amy's MTHFR Journey
Even though we talk about folate *constantly* and don't seem to talk about any other vitamins, it isn't just about the folate. In this episode, we'll talk about: What entire group of vitamins works together to make methylation and cellular energy happen What other B vitamin is absolutely necessary for MTHFR to function - it might even be more important than folate! Amy's MTHFR story and why she's so absurdly passionate about this whole topic. For complete show notes, follow this link - this post refers to chemical pathways and the visuals are in the show notes.
September 13, 2020
Methylfolate, or a High-Folate Diet Makes Me Feel BAD.
What we have here, is an MTHFR situation. In this episode we'll talk about: The three scenarios when taking the right kind of folate feels yucky What that might mean about you How to fix it Easy-peasy-lemon-squeezie (as my 5-year-old says it.) Here are the full show notes with links to more information. Keep your eyes peeled for MTHFR courses - we're starting out with a Help! I've Just Been Told I Have MTHFR And I Don't Get It quickie class.
September 06, 2020
What to Eat for MTHFR Mutants. More Importantly, What NOT to Eat.
We've talked about the difference between natural folate and synthetic folic acid, but what does that mean in terms of eating for your MTHFR mutation? LOTS of things... Tune in to learn: The two foods that you absolutely should never eat, ever. The ten foods highest in natural folate that you can add to your diet today. Easy substitutions for foods that are fortified with folic acid. The big payoff to changing your diet. The two situations where a high-natural-folate diet might not be right for you (or, might be downright wrong). Also - take a look at the show notes here for an MTHFR breakfast that will give you 77.5% of your daily folate needs. Easy.
August 30, 2020
Psst... There are Different Types of Folate. Which is Best For You?
The term "folate" is incredibly confusing because for whatever reason, the term is used interchangeably with "folic acid," which is an entirely different thing. This week let's talk about folate, folic acid, folinic acid, and 5-LMTHF and also, which is best to take if you happen to be an MTHFR mutant because really, who actually knows what the eff folinic acid is? We'll talk about: Which type builds up toxic unmetabolized products in the blood Which type is found naturally in foods like lentils and dark green leafy veggies Which type feeds most directly into cellular energy Which type feeds into neurotransmitter production Which type entirely bypasses the MTHFR enzyme. Also - great news about an MTHFR community, coming soon. See the full show notes here!
August 23, 2020
This Vitamin Could Be Hurting You. Not Just For MTHFR!
There is a vitamin that is helpful in normal doses, but toxic in high doses. It is added to your food, energy drinks, and of course, your multivitamin. It's folic acid - and it's not just a problem for MTHFR mutants. In this episode you'll learn: How folic acid is linked to cancer promotion The strange, double-edged relationship between folic acid and cognitive decline in the elderly What happens when too much folic acid stays in your bloodstream How MTHFR mutations amplify the problems Visit the show notes here for all the details, links to research articles, and don't forget to sign up for the mailing list so you're the first to know when our MTHFR courses go live.
August 16, 2020
MTHFR and Neurotransmitters - An Unholy Marriage
Why does MTHFR have so many mental and psychological effects? This is it! Find out: What MTHFR has to do with neurotransmitter formation What BH4 is and why should I possibly care? Why low serotonin feels like you want pizza and Ben & Jerry's and low dopamine feels like *meh.* What you can do with SAMe to help How sleep gets tangled up in all of this One simple step to start fixing sleep. For complete show notes and visuals of the pathway involved, check out the post.
August 09, 2020
MTHFR Is In Bed With Estrogen. Now What?
MTHFR doesn't seem obviously linked to hormone balance, so what is happening here? Listen to find out: Why in the world MTHFR gets its sticky fingers into everything. Why one particular estrogen is called the "Marilyn Monroe Hormone" How broccoli can save the day The horrifying link with man-boobs. For the full show notes and more explanation about the Marilyn Monroe hormone, check it out here. Next week we'll talk about MTHFR and neurotransmitters and then we can get on to the juicy stuff, like why your multivitamin might be doing more harm than good.
August 02, 2020
Methylation, Detoxification, and the Glamorous MTHFR Lifestyle.
What is the glamorous MTHFR lifestyle? It's maybe a bit less glamorous and more just... lifestyle.  In this episode we'll talk about: What does detox mean for normal people who don't live on wheat germ and sprouts? What do methylation and MTHFR have to do with detoxification? What types of things need to be methylated to be eliminated? What does that have to do with urea? And why do I care? Does "sweating it out" really do anything? And for real - what is this MTHFR lifestyle of which you speak? We're getting to the end (yay!) of the background info and soon we'll get into the juicy balancing-your-methylation stuff, so stay with me!  If you're a visual person, like I am, then there are some great graphics in the show transcript that will help this all to make more sense.
July 26, 2020
Why Is Methylation Important? Gene Regulation.
In this episode we'll cover: The four major reasons why methylation matters The mutant Mickey Mouse of methylation The big reasons why we need to be able to turn genes on and off and why we need to methylate to do that Why brains and babies are so methylation dependent The proof that we can actually impact this by optimizing our methylation cycle  It's a big episode! If you want to see pictures of mutant Mickey Mouse, check the full text here.
July 19, 2020
Who Should Care About MTHFR Mutation?
The internet seems to think that everyone should, but it simply isn't true. In this episode we'll cover: The four circumstances in which MTHFR mutations REALLY matter The main symptoms that indicate that you may want to dig deeper into your methylation status Who doesn't need to be worried about it at all. For the written version of this podcast, you can check here.
July 12, 2020
MTHFR Testing and Results - What Does This Mean?
Testing isn't for everyone. In this episode, you'll learn: When your doctor might test. Who really should test Who really shouldn't How to test on your own How to read the results (what do those plusses and minuses really mean?) How far your DNA can stretch, if you use all of it in your body (just for fun). For detailed show notes, links to resources and pictures of test results, check out the complete post here.
July 05, 2020
Health Problems Linked to MTHFR Mutations
This week we'll talk about the health issues associated with MTHFR mutations (or polymorphisms). These include: Midline abnormalities Cancer Cardiac disease Fertility issues Neurological problems Mood and psychological differences. It's kind of a depressing list, made far less depressing by the miracle that is epigenetic. Remember, MTHFR polymorphisms are actionable, meaning you CAN change their impact on your health. Also, learn about a bonus MTHFR superpower! It's not quite eyeball laser beams, but it's still pretty good. Check out the full show notes here.
June 28, 2020
What is MTHFR in the simplest terms possible? It's a magic chair.
MTHFR research on the internet can lead to a back hole of confusion, so let's demystify it with the "magic chair" analogy. What is the MTHFR magic chair? Why do some mutations matter to the magic chair and others don't? When do bottlenecks happen at the magic chair? Why does the MTHFR magic chair need to be working?  Why does anybody care enough to make a whole season of podcast episodes about it? Let's dive in to the first layer of MTHFR information and we'll build on this knowledge with every episode. For show notes and more information you can see the blog post here.
June 21, 2020
Trailer and bonus P.S.A. from a 4-year-old.
To Health With That! is a great way to learn a lot about a big health topic in small, bite-sized pieces. Season One will cover the ins and outs of the MTHFR mutation; which, aside from being the trendiest new problem to have, is also a real medical issue with hard science and very particular challenges.  Also, it is near and dear to my heart (I'm Dr. Amy -- your host), because I have a compound heterozygous mutation (or polymorphism, if you want to get all P.C. on me). So, from one mutant to another, let's dive in.  Subscribe so you don't miss it! Season One: MTHFR Mutation Website for free downloads, fact sheets, tips and action items: To Health With That! To Leave a Message for the Show: Go Here and click the + Message button under the logo.
June 02, 2020